Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085433420> ?p ?o ?g. }
- W2085433420 endingPage "82" @default.
- W2085433420 startingPage "77" @default.
- W2085433420 abstract "Endothelial integrity is dependent on intracellular adherens junctions formed by complexes of vascular endothelial (VE)-cadherin and catenins. We have previously demonstrated that exposing endothelial cells (EC) to breast cancer cell-conditioned media (CM) for 24 h results in a reduction in VE-cadherin protein and mRNA levels. Herein, we examined the mechanism(s) involved in the downregulation of VE-cadherin by CM. Human dermal microvascular EC exposed to CM showed a downregulation in VE-cadherin promoter activity and upregulation of Twist, Slug, and Snail expression. Reporter gene analysis demonstrated a direct repression of the VE-cadherin promoter by Slug, Snail, and Twist expression plasmids. At least two E-box motifs appear to be involved in this regulatory process as shown by electrophoretic mobility shift assays. These results suggest that factors released by breast cancer cells are able to upregulate Twist, Slug, and Snail expression in EC, which in turn downregulate the activity of the VE-cadherin promoter." @default.
- W2085433420 created "2016-06-24" @default.
- W2085433420 creator A5004961057 @default.
- W2085433420 creator A5032359568 @default.
- W2085433420 creator A5046097404 @default.
- W2085433420 creator A5090485594 @default.
- W2085433420 date "2009-02-01" @default.
- W2085433420 modified "2023-10-09" @default.
- W2085433420 title "Tumor-induced upregulation of Twist, Snail, and Slug represses the activity of the human VE-cadherin promoter" @default.
- W2085433420 cites W1934202741 @default.
- W2085433420 cites W1964052195 @default.
- W2085433420 cites W1965255998 @default.
- W2085433420 cites W1986248060 @default.
- W2085433420 cites W1994699007 @default.
- W2085433420 cites W2005261405 @default.
- W2085433420 cites W2017695799 @default.
- W2085433420 cites W2032674547 @default.
- W2085433420 cites W2035296224 @default.
- W2085433420 cites W2039871999 @default.
- W2085433420 cites W2056318837 @default.
- W2085433420 cites W2057711788 @default.
- W2085433420 cites W2069035004 @default.
- W2085433420 cites W2105822318 @default.
- W2085433420 cites W2145757273 @default.
- W2085433420 cites W2148294117 @default.
- W2085433420 cites W2166573361 @default.
- W2085433420 cites W2168180494 @default.
- W2085433420 cites W2170181331 @default.
- W2085433420 cites W2172160601 @default.
- W2085433420 doi "https://doi.org/10.1016/j.abb.2008.11.016" @default.
- W2085433420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19046938" @default.
- W2085433420 hasPublicationYear "2009" @default.
- W2085433420 type Work @default.
- W2085433420 sameAs 2085433420 @default.
- W2085433420 citedByCount "66" @default.
- W2085433420 countsByYear W20854334202012 @default.
- W2085433420 countsByYear W20854334202013 @default.
- W2085433420 countsByYear W20854334202014 @default.
- W2085433420 countsByYear W20854334202015 @default.
- W2085433420 countsByYear W20854334202016 @default.
- W2085433420 countsByYear W20854334202017 @default.
- W2085433420 countsByYear W20854334202018 @default.
- W2085433420 countsByYear W20854334202019 @default.
- W2085433420 countsByYear W20854334202020 @default.
- W2085433420 countsByYear W20854334202021 @default.
- W2085433420 countsByYear W20854334202022 @default.
- W2085433420 crossrefType "journal-article" @default.
- W2085433420 hasAuthorship W2085433420A5004961057 @default.
- W2085433420 hasAuthorship W2085433420A5032359568 @default.
- W2085433420 hasAuthorship W2085433420A5046097404 @default.
- W2085433420 hasAuthorship W2085433420A5090485594 @default.
- W2085433420 hasConcept C104317684 @default.
- W2085433420 hasConcept C127561419 @default.
- W2085433420 hasConcept C1491633281 @default.
- W2085433420 hasConcept C149402561 @default.
- W2085433420 hasConcept C153911025 @default.
- W2085433420 hasConcept C185592680 @default.
- W2085433420 hasConcept C18903297 @default.
- W2085433420 hasConcept C201508349 @default.
- W2085433420 hasConcept C2779965526 @default.
- W2085433420 hasConcept C2781381752 @default.
- W2085433420 hasConcept C502942594 @default.
- W2085433420 hasConcept C55493867 @default.
- W2085433420 hasConcept C86803240 @default.
- W2085433420 hasConcept C95444343 @default.
- W2085433420 hasConceptScore W2085433420C104317684 @default.
- W2085433420 hasConceptScore W2085433420C127561419 @default.
- W2085433420 hasConceptScore W2085433420C1491633281 @default.
- W2085433420 hasConceptScore W2085433420C149402561 @default.
- W2085433420 hasConceptScore W2085433420C153911025 @default.
- W2085433420 hasConceptScore W2085433420C185592680 @default.
- W2085433420 hasConceptScore W2085433420C18903297 @default.
- W2085433420 hasConceptScore W2085433420C201508349 @default.
- W2085433420 hasConceptScore W2085433420C2779965526 @default.
- W2085433420 hasConceptScore W2085433420C2781381752 @default.
- W2085433420 hasConceptScore W2085433420C502942594 @default.
- W2085433420 hasConceptScore W2085433420C55493867 @default.
- W2085433420 hasConceptScore W2085433420C86803240 @default.
- W2085433420 hasConceptScore W2085433420C95444343 @default.
- W2085433420 hasIssue "1-2" @default.
- W2085433420 hasLocation W20854334201 @default.
- W2085433420 hasLocation W20854334202 @default.
- W2085433420 hasOpenAccess W2085433420 @default.
- W2085433420 hasPrimaryLocation W20854334201 @default.
- W2085433420 hasRelatedWork W1913011518 @default.
- W2085433420 hasRelatedWork W1988660193 @default.
- W2085433420 hasRelatedWork W2010710842 @default.
- W2085433420 hasRelatedWork W2123863025 @default.
- W2085433420 hasRelatedWork W2147283821 @default.
- W2085433420 hasRelatedWork W2224875367 @default.
- W2085433420 hasRelatedWork W2286609925 @default.
- W2085433420 hasRelatedWork W2406356237 @default.
- W2085433420 hasRelatedWork W3145379231 @default.
- W2085433420 hasRelatedWork W4245622537 @default.
- W2085433420 hasVolume "482" @default.
- W2085433420 isParatext "false" @default.
- W2085433420 isRetracted "false" @default.
- W2085433420 magId "2085433420" @default.