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• W2085441623 abstract "Twenty macaques were used to evaluate the ability of nonpathogenic SIVmacor nonpathogenic chimeric SIV-HIV (SHIV) to induce protection in macaques against superinfection with a pathogenic variant of SHIV (SHIVKU-1) originally containing thetat, rev, vpu,andenvof HIV-1 (strain HXB2) in a genetic background of SIVmac239. Specifically, three macaques inoculated with molecularly cloned, macrophage-tropic SIVmacLG1 developed an early systemic infection but recovered with only traces of SIVmacDNA in visceral lymphoid tissues. These animals were then inoculated parenterally with pathogenic SHIVKU-1. All three animals resisted infection with SHIVKU-1, as indicated by lack of virus recovery and absence of SHIV-specificenvandvpusequences in the visceral lymphoid tissues and multiple regions in the CNS. We also examined the ability of five macaques that had been inoculated with nonpathogenic SHIV (NP-SHIV) to withstand challenge with the pathogenic SHIVKU-1. Like the SIVmacLG1-inoculated macaques, these animals also resisted SHIVKU-1challenge as judged by the inability to recover infectious virus, normal CD4+T cell counts, and the absence of SHIVKU-1signature sequences in the lymph node tissue. Thus, eight of eight animals that developed control over primary lentivirus infections had also developed resistance to infection with pathogenic SHIVKU-1. Three groups of macaques were used as controls for this study. The first group consisted of six macaques inoculated with SHIVKU-1alone. All animals developed viremia, showed severe loss of CD4+T cells within 4 weeks, and succumbed to AIDS within 6 months. The second group of three macaques was inoculated first with SHIVKU-1and inoculated later with uncloned, neurovirulent SIVmac7F-Lu. A third group of three macaques was inoculated with SIVmac7F-Lu followed by inoculation with SHIVKU-1. PCR analyses using oligonucleotide primers specific for the SIV or HIVenvrevealed that macaques from the last two groups had widespread infection with both SHIVKU-1and SIVmac, indicating that animals that failed to control productive replication of either SHIVKU-1or SIVmac7F-Lu could not resist superinfection with the other virus. These data indicate that sterilizing immunity against the virulent SHIV could be induced in animals that had experienced an immunizing infection. Moreover, the divergence of the envelope glycoprotein of the protective avirulent and virulent challenge virus suggests that a single vaccine could protect against infection with a virus containing a different envelope glycoprotein." @default.
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• W2085441623 date "1997-08-01" @default.
• W2085441623 modified "2023-10-17" @default.
• W2085441623 title "Infected Macaques That Controlled Replication of SIVmacor Nonpathogenic SHIV Developed Sterilizing Resistance against Pathogenic SHIVKU-1" @default.
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• W2085441623 doi "https://doi.org/10.1006/viro.1997.8662" @default.
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