FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085442021> ?p ?o ?g. }

• W2085442021 endingPage "923" @default.
• W2085442021 startingPage "913" @default.
• W2085442021 abstract "Alpha-synuclein oligomerization and aggregation are considered to have a role in the pathogenesis of neurodegenerative diseases. However, despite numerous in vitro studies, the impact of aggregates in the intact brain is unclear. In vitro, oxidative/nitrative stress and acidity induce α-synuclein oligomerization. These conditions favoring α-synuclein fibrillization are present in the ischemic brain, which may serve as an in vivo model to study α-synuclein aggregation. In this study, we show that 30-minute proximal middle cerebral artery (MCA) occlusion and 72 hours reperfusion induce oligomerization of wild-type α-synuclein in the ischemic mouse brain. The nonamyloidogenic isoform β-synuclein did not form oligomers. Alpha-synuclein aggregates were confined to neurons and colocalized with ubiquitin immunoreactivity. We also found that 30 minutes proximal MCA occlusion and 24 hours reperfusion induced larger infarcts in C57BL/6(Thy1)-h[A30P]alphaSYN transgenic mice, which have an increased tendency to form synuclein fibrils. Trangenics also developed more selective neuronal necrosis when subjected to 20 minutes distal MCA occlusion and 72 hours reperfusion. Enhanced 3-nitrotyrosine immunoreactivity in transgenic mice suggests that oxidative/nitrative stress may be one of the mechanisms mediating aggregate toxicity. Thus, the increased vulnerability of transgenic mice to ischemia suggests that α-synuclein aggregates not only form during ischemia but also negatively impact neuronal survival, supporting the idea that α-synuclein misfolding may be neurotoxic." @default.
• W2085442021 created "2016-06-24" @default.
• W2085442021 creator A5000816967 @default.
• W2085442021 creator A5001760027 @default.
• W2085442021 creator A5012319700 @default.
• W2085442021 creator A5012472027 @default.
• W2085442021 creator A5017053356 @default.
• W2085442021 creator A5019817327 @default.
• W2085442021 creator A5022880417 @default.
• W2085442021 creator A5062490390 @default.
• W2085442021 creator A5079111087 @default.
• W2085442021 date "2010-09-29" @default.
• W2085442021 modified "2023-10-13" @default.
• W2085442021 title "Alpha-Synuclein Aggregation Induced by Brief Ischemia Negatively Impacts Neuronal Survival <i>in vivo</i>: A Study in [A30P]alpha-Synuclein Transgenic Mouse" @default.
• W2085442021 cites W1518241176 @default.
• W2085442021 cites W1527671059 @default.
• W2085442021 cites W1557235501 @default.
• W2085442021 cites W1565076702 @default.
• W2085442021 cites W1823487357 @default.
• W2085442021 cites W1968390598 @default.
• W2085442021 cites W1970122257 @default.
• W2085442021 cites W1977846417 @default.
• W2085442021 cites W1986625112 @default.
• W2085442021 cites W1987674477 @default.
• W2085442021 cites W1988146888 @default.
• W2085442021 cites W1988369116 @default.
• W2085442021 cites W1994044388 @default.
• W2085442021 cites W2001407922 @default.
• W2085442021 cites W2006492012 @default.
• W2085442021 cites W2007157911 @default.
• W2085442021 cites W2009556855 @default.
• W2085442021 cites W2013213453 @default.
• W2085442021 cites W2013313629 @default.
• W2085442021 cites W2021977313 @default.
• W2085442021 cites W2025922492 @default.
• W2085442021 cites W2029892042 @default.
• W2085442021 cites W2038642985 @default.
• W2085442021 cites W2050786534 @default.
• W2085442021 cites W2056304503 @default.
• W2085442021 cites W2061995199 @default.
• W2085442021 cites W2066594212 @default.
• W2085442021 cites W2071087722 @default.
• W2085442021 cites W2072794630 @default.
• W2085442021 cites W2073135755 @default.
• W2085442021 cites W2077893927 @default.
• W2085442021 cites W2080190164 @default.
• W2085442021 cites W2081968259 @default.
• W2085442021 cites W2086121277 @default.
• W2085442021 cites W2088481573 @default.
• W2085442021 cites W2091265794 @default.
• W2085442021 cites W2098087911 @default.
• W2085442021 cites W2104855192 @default.
• W2085442021 cites W2106200048 @default.
• W2085442021 cites W2116597539 @default.
• W2085442021 cites W2131207606 @default.
• W2085442021 cites W2133068803 @default.
• W2085442021 cites W2136321913 @default.
• W2085442021 cites W2145294211 @default.
• W2085442021 cites W2166789153 @default.
• W2085442021 cites W2354791377 @default.
• W2085442021 cites W2427551708 @default.
• W2085442021 cites W4255597145 @default.
• W2085442021 cites W4296217171 @default.
• W2085442021 doi "https://doi.org/10.1038/jcbfm.2010.170" @default.
• W2085442021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3063624" @default.
• W2085442021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20877387" @default.
• W2085442021 hasPublicationYear "2010" @default.
• W2085442021 type Work @default.
• W2085442021 sameAs 2085442021 @default.
• W2085442021 citedByCount "39" @default.
• W2085442021 countsByYear W20854420212014 @default.
• W2085442021 countsByYear W20854420212015 @default.
• W2085442021 countsByYear W20854420212016 @default.
• W2085442021 countsByYear W20854420212017 @default.
• W2085442021 countsByYear W20854420212018 @default.
• W2085442021 countsByYear W20854420212019 @default.
• W2085442021 countsByYear W20854420212020 @default.
• W2085442021 countsByYear W20854420212021 @default.
• W2085442021 countsByYear W20854420212022 @default.
• W2085442021 countsByYear W20854420212023 @default.
• W2085442021 crossrefType "journal-article" @default.
• W2085442021 hasAuthorship W2085442021A5000816967 @default.
• W2085442021 hasAuthorship W2085442021A5001760027 @default.
• W2085442021 hasAuthorship W2085442021A5012319700 @default.
• W2085442021 hasAuthorship W2085442021A5012472027 @default.
• W2085442021 hasAuthorship W2085442021A5017053356 @default.
• W2085442021 hasAuthorship W2085442021A5019817327 @default.
• W2085442021 hasAuthorship W2085442021A5022880417 @default.
• W2085442021 hasAuthorship W2085442021A5062490390 @default.
• W2085442021 hasAuthorship W2085442021A5079111087 @default.
• W2085442021 hasBestOaLocation W20854420211 @default.
• W2085442021 hasConcept C102230213 @default.
• W2085442021 hasConcept C104317684 @default.
• W2085442021 hasConcept C126322002 @default.
• W2085442021 hasConcept C136238340 @default.
• W2085442021 hasConcept C141035611 @default.
• W2085442021 hasConcept C142724271 @default.
• W2085442021 hasConcept C150903083 @default.

• next