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• W2085442937 endingPage "4322" @default.
• W2085442937 startingPage "4314" @default.
• W2085442937 abstract "The structural proteins (SP) of the Togaviridae can be deleted in defective interfering RNAs. The dispensability of viral SP has allowed construction of noninfectious viral expression vectors and replicons from viruses of the Alphavirus and Rubivirus genera. Nevertheless, in this study, we found that the SP of rubella virus (RUB) could enhance expression of reporter genes from RUB replicons in trans. SP enhancement required capsid protein (CP) expression and was not due to RNA-RNA recombination. Accumulation of minus- and plus-strand RNAs from replicons was observed in the presence of SP, suggesting that SP specifically affects RNA synthesis. By using replicons containing an antibiotic resistance gene, we found 2- to 50-fold increases in the number of cells surviving selection in the presence of SP. The increases depended significantly on the amount of transfected RNA. Small amounts of RNA or templates that replicated inefficiently showed more enhancement. The infectivity of infectious RNA was increased by at least 10-fold in cells expressing CP. Moreover, virus infectivity was greatly enhanced in such cells. In other cells that expressed higher levels of CP, RNA replication of replicons was inhibited. Thus, depending on conditions, CP can markedly enhance or inhibit RUB RNA replication." @default.
• W2085442937 created "2016-06-24" @default.
• W2085442937 creator A5001840550 @default.
• W2085442937 creator A5038828045 @default.
• W2085442937 date "2004-04-15" @default.
• W2085442937 modified "2023-10-18" @default.
• W2085442937 title "Rubella Virus Capsid Protein Modulates Viral Genome Replication and Virus Infectivity" @default.
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• W2085442937 doi "https://doi.org/10.1128/jvi.78.8.4314-4322.2004" @default.
• W2085442937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/374250" @default.
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• W2085442937 hasPublicationYear "2004" @default.
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