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- W2085446376 abstract "A protein (Rp66) of 66 kDa was shown by DNA-binding protein blot assay to bind to a human repetitive DNA sequence (low-repeat sequence; LRS) in each of 10 transformed human cell lines examined. This protein-DNA interaction was not observed in 11 normal human cell cultures or in the Chinese hamster cell line CHO-K1. Gel retardation assay confirmed the specificity of the protein-DNA binding between Rp66 and LRS. In a histiocytic lymphoma human cell line, U937, that can be induced to differentiate in the presence of phorbol ester, this binding disappeared after cell differentiation. These together with other results cited suggest a regulatory role for these repetitive sequences in the human genome, with particular application to cancer." @default.
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- W2085446376 date "1989-11-01" @default.
- W2085446376 modified "2023-09-25" @default.
- W2085446376 title "A nuclear protein associated with human cancer cells binds preferentially to a human repetitive DNA sequence." @default.
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- W2085446376 doi "https://doi.org/10.1073/pnas.86.21.8472" @default.
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