Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085451391> ?p ?o ?g. }
- W2085451391 endingPage "55" @default.
- W2085451391 startingPage "42" @default.
- W2085451391 abstract "Cytochrome P450 1 (CYP1) mRNA induction patterns in three-spined stickleback (Gasterosteus aculeatus) were explored for use in environmental monitoring of aryl hydrocarbon receptor (AHR) agonists. The cDNAs of stickleback CYP1A, CYP1B1, CYP1C1, and CYP1C2 were cloned and their basal and induced expression patterns were determined in the brain, gill, liver and kidney. Also, their induction time courses were compared after waterborne exposure to a transient (indigo) or a persistent (3,3′,4,4′,5-pentacholorbiphenyl PCB 126) AHR agonist. The cloned stickleback CYP1s exhibited a high amino acid sequence identity compared with their zebrafish orthologs and their constitutive tissue distribution patterns largely agreed with those reported in other species. PCB 126 (100 nM) induced different CYP1 expression patterns in the four tissues, suggesting tissue-specific regulation. Both indigo (1 nM) and PCB 126 (10 nM) induced a strong CYP1 expression in gills. However, while PCB 126 gave rise to a high and persistent induction in gills and liver, induction by indigo was transient in both organs. The number of putative dioxin response elements found in each CYP1 gene promoter roughly reflected the induction levels of the genes. The high responsiveness of CYP1A, CYP1B1, and CYP1C1 observed in several organs suggests that three-spined stickleback is suitable for monitoring of pollution with AHR agonists." @default.
- W2085451391 created "2016-06-24" @default.
- W2085451391 creator A5021819422 @default.
- W2085451391 creator A5051449882 @default.
- W2085451391 creator A5068859307 @default.
- W2085451391 creator A5078853585 @default.
- W2085451391 date "2011-06-01" @default.
- W2085451391 modified "2023-09-27" @default.
- W2085451391 title "Cytochrome P450 1A, 1B, and 1C mRNA induction patterns in three-spined stickleback exposed to a transient and a persistent inducer" @default.
- W2085451391 cites W152450789 @default.
- W2085451391 cites W1545201063 @default.
- W2085451391 cites W1551348338 @default.
- W2085451391 cites W1881840670 @default.
- W2085451391 cites W1935479846 @default.
- W2085451391 cites W1970954403 @default.
- W2085451391 cites W1971772902 @default.
- W2085451391 cites W1982766174 @default.
- W2085451391 cites W1983322295 @default.
- W2085451391 cites W1983720112 @default.
- W2085451391 cites W1985039245 @default.
- W2085451391 cites W1985484130 @default.
- W2085451391 cites W1985754063 @default.
- W2085451391 cites W1989060543 @default.
- W2085451391 cites W1989095073 @default.
- W2085451391 cites W2001773212 @default.
- W2085451391 cites W2003410989 @default.
- W2085451391 cites W2009896818 @default.
- W2085451391 cites W2010031741 @default.
- W2085451391 cites W2011427930 @default.
- W2085451391 cites W2011529811 @default.
- W2085451391 cites W2013066674 @default.
- W2085451391 cites W2015036377 @default.
- W2085451391 cites W2027623576 @default.
- W2085451391 cites W2031179297 @default.
- W2085451391 cites W2033799014 @default.
- W2085451391 cites W2038193477 @default.
- W2085451391 cites W2038972102 @default.
- W2085451391 cites W2053181592 @default.
- W2085451391 cites W2055084808 @default.
- W2085451391 cites W2058667658 @default.
- W2085451391 cites W2058716924 @default.
- W2085451391 cites W2059883297 @default.
- W2085451391 cites W2060151171 @default.
- W2085451391 cites W2062359220 @default.
- W2085451391 cites W2069704428 @default.
- W2085451391 cites W2071843955 @default.
- W2085451391 cites W2073797037 @default.
- W2085451391 cites W2074183900 @default.
- W2085451391 cites W2077382905 @default.
- W2085451391 cites W2087413883 @default.
- W2085451391 cites W2089387410 @default.
- W2085451391 cites W2104276196 @default.
- W2085451391 cites W2107277218 @default.
- W2085451391 cites W2112014421 @default.
- W2085451391 cites W2113672678 @default.
- W2085451391 cites W2114570899 @default.
- W2085451391 cites W2114629114 @default.
- W2085451391 cites W2116367493 @default.
- W2085451391 cites W2123711126 @default.
- W2085451391 cites W2136309995 @default.
- W2085451391 cites W2136328669 @default.
- W2085451391 cites W2136611153 @default.
- W2085451391 cites W2139972154 @default.
- W2085451391 cites W2141135690 @default.
- W2085451391 cites W2147188473 @default.
- W2085451391 cites W2149339192 @default.
- W2085451391 cites W2149548143 @default.
- W2085451391 cites W2160109681 @default.
- W2085451391 cites W2164668113 @default.
- W2085451391 cites W2170195945 @default.
- W2085451391 cites W2171560053 @default.
- W2085451391 cites W4231620004 @default.
- W2085451391 doi "https://doi.org/10.1016/j.cbpc.2011.02.005" @default.
- W2085451391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3560405" @default.
- W2085451391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21354474" @default.
- W2085451391 hasPublicationYear "2011" @default.
- W2085451391 type Work @default.
- W2085451391 sameAs 2085451391 @default.
- W2085451391 citedByCount "26" @default.
- W2085451391 countsByYear W20854513912013 @default.
- W2085451391 countsByYear W20854513912014 @default.
- W2085451391 countsByYear W20854513912015 @default.
- W2085451391 countsByYear W20854513912016 @default.
- W2085451391 countsByYear W20854513912017 @default.
- W2085451391 countsByYear W20854513912018 @default.
- W2085451391 countsByYear W20854513912019 @default.
- W2085451391 countsByYear W20854513912020 @default.
- W2085451391 countsByYear W20854513912021 @default.
- W2085451391 crossrefType "journal-article" @default.
- W2085451391 hasAuthorship W2085451391A5021819422 @default.
- W2085451391 hasAuthorship W2085451391A5051449882 @default.
- W2085451391 hasAuthorship W2085451391A5068859307 @default.
- W2085451391 hasAuthorship W2085451391A5078853585 @default.
- W2085451391 hasBestOaLocation W20854513912 @default.
- W2085451391 hasConcept C104317684 @default.
- W2085451391 hasConcept C134018914 @default.
- W2085451391 hasConcept C153911025 @default.
- W2085451391 hasConcept C155701950 @default.