Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085451857> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2085451857 endingPage "221" @default.
- W2085451857 startingPage "215" @default.
- W2085451857 abstract "This study was undertaken in order to investigate the possible interactions between nitric oxide and arachidonic acid (AA) in Venus verrucosa oocytes. We perifused isolated oocytes to determine the effect of the following substances on [3H]arachidonic acid release ([3H]AA): (1) A 23187, a calcium ionophore; (2) nitric oxide (NO) donors; (3) 1,1,1-trifluoromethyl-6,9,12,15 heicosatetraen-2-one (AACOCF3), a specific phospholipase A2 (PLA2) inhibitor; (4) [5′-hydroxymethyl-2′-furyl]-1-benzyl indazole (YC-1) and 1H-[1,2,4]oxadiazolo[4,3-α]quinoxalin-1-one (ODQ), specific soluble guanylyl cyclase activator and inhibitor, respectively; (5) l-arginine, the substrate of nitric oxide synthase; (6) l-nitroarginine methyl esther (l-NAME), an inhibitor of nitric oxide synthase. Our results demonstrated that: (a) the calcium ionophore dose-dependently increased [3H]arachidonic acid release; (b) the NO donors sodium nitroprusside (SNP) and linsidomine (SIN-1) highly increased [3H]arachidonic acid output, while S-nitroso-N-acetylpenicillamine (SNAP) was without effect; (c) AACOCF3 completely blocked the [3H]arachidonic acid release induced by SNP and SIN-1; (d) YC-1 increased [3H]arachidonic acid release, while ODQ completely counteracted SNP response; (e) [3H]arachidonic acid output was also increased by l-arginine; (f) a similar effect was, paradoxically, obtained in the presence of l-NAME. Furthermore, using RT-PCR we demonstrated in the same cells the presence of a nitric oxide synthase (NOS) mRNA, whose expression was not modulated by interleukin 1β (IL-1β). These results demonstrate the presence of a both calcium-dependent and NO-sensitive PLA2 and of nitric oxide synthase in V. verrucosa oocytes. Our data also suggest a co-action of the two pathways in the control of reproduction in this bivalve." @default.
- W2085451857 created "2016-06-24" @default.
- W2085451857 creator A5026847175 @default.
- W2085451857 creator A5028104592 @default.
- W2085451857 creator A5034436523 @default.
- W2085451857 creator A5037379890 @default.
- W2085451857 creator A5038440232 @default.
- W2085451857 creator A5043129468 @default.
- W2085451857 creator A5066652587 @default.
- W2085451857 date "2003-02-01" @default.
- W2085451857 modified "2023-09-26" @default.
- W2085451857 title "Nitric oxide-mediated arachidonic acid release from perifused Venus verrucosa oocytes" @default.
- W2085451857 cites W1874183695 @default.
- W2085451857 cites W1969341053 @default.
- W2085451857 cites W1970926970 @default.
- W2085451857 cites W1990185003 @default.
- W2085451857 cites W1991076639 @default.
- W2085451857 cites W1992049177 @default.
- W2085451857 cites W2008568876 @default.
- W2085451857 cites W2032120730 @default.
- W2085451857 cites W2034769077 @default.
- W2085451857 cites W2038162047 @default.
- W2085451857 cites W2041280493 @default.
- W2085451857 cites W2054061636 @default.
- W2085451857 cites W2058855902 @default.
- W2085451857 cites W2062937134 @default.
- W2085451857 cites W2071610863 @default.
- W2085451857 cites W2071929995 @default.
- W2085451857 cites W2074260405 @default.
- W2085451857 cites W2084224718 @default.
- W2085451857 cites W2084570265 @default.
- W2085451857 cites W2086871241 @default.
- W2085451857 cites W2087368947 @default.
- W2085451857 cites W2092197082 @default.
- W2085451857 cites W2107111331 @default.
- W2085451857 cites W2112645007 @default.
- W2085451857 cites W2116377440 @default.
- W2085451857 cites W2134720662 @default.
- W2085451857 cites W2150152732 @default.
- W2085451857 doi "https://doi.org/10.1016/s0016-6480(02)00639-1" @default.
- W2085451857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12606264" @default.
- W2085451857 hasPublicationYear "2003" @default.
- W2085451857 type Work @default.
- W2085451857 sameAs 2085451857 @default.
- W2085451857 citedByCount "8" @default.
- W2085451857 countsByYear W20854518572013 @default.
- W2085451857 crossrefType "journal-article" @default.
- W2085451857 hasAuthorship W2085451857A5026847175 @default.
- W2085451857 hasAuthorship W2085451857A5028104592 @default.
- W2085451857 hasAuthorship W2085451857A5034436523 @default.
- W2085451857 hasAuthorship W2085451857A5037379890 @default.
- W2085451857 hasAuthorship W2085451857A5038440232 @default.
- W2085451857 hasAuthorship W2085451857A5043129468 @default.
- W2085451857 hasAuthorship W2085451857A5066652587 @default.
- W2085451857 hasConcept C126322002 @default.
- W2085451857 hasConcept C134018914 @default.
- W2085451857 hasConcept C181199279 @default.
- W2085451857 hasConcept C2776551241 @default.
- W2085451857 hasConcept C2777622882 @default.
- W2085451857 hasConcept C2778078955 @default.
- W2085451857 hasConcept C2779610285 @default.
- W2085451857 hasConcept C519063684 @default.
- W2085451857 hasConcept C519581460 @default.
- W2085451857 hasConcept C55493867 @default.
- W2085451857 hasConcept C71924100 @default.
- W2085451857 hasConcept C86803240 @default.
- W2085451857 hasConceptScore W2085451857C126322002 @default.
- W2085451857 hasConceptScore W2085451857C134018914 @default.
- W2085451857 hasConceptScore W2085451857C181199279 @default.
- W2085451857 hasConceptScore W2085451857C2776551241 @default.
- W2085451857 hasConceptScore W2085451857C2777622882 @default.
- W2085451857 hasConceptScore W2085451857C2778078955 @default.
- W2085451857 hasConceptScore W2085451857C2779610285 @default.
- W2085451857 hasConceptScore W2085451857C519063684 @default.
- W2085451857 hasConceptScore W2085451857C519581460 @default.
- W2085451857 hasConceptScore W2085451857C55493867 @default.
- W2085451857 hasConceptScore W2085451857C71924100 @default.
- W2085451857 hasConceptScore W2085451857C86803240 @default.
- W2085451857 hasIssue "3" @default.
- W2085451857 hasLocation W20854518571 @default.
- W2085451857 hasLocation W20854518572 @default.
- W2085451857 hasOpenAccess W2085451857 @default.
- W2085451857 hasPrimaryLocation W20854518571 @default.
- W2085451857 hasRelatedWork W1966928669 @default.
- W2085451857 hasRelatedWork W2003842308 @default.
- W2085451857 hasRelatedWork W2008087125 @default.
- W2085451857 hasRelatedWork W2017375758 @default.
- W2085451857 hasRelatedWork W2032738451 @default.
- W2085451857 hasRelatedWork W2064236298 @default.
- W2085451857 hasRelatedWork W2089295326 @default.
- W2085451857 hasRelatedWork W2095093072 @default.
- W2085451857 hasRelatedWork W2099366831 @default.
- W2085451857 hasRelatedWork W2352238251 @default.
- W2085451857 hasVolume "130" @default.
- W2085451857 isParatext "false" @default.
- W2085451857 isRetracted "false" @default.
- W2085451857 magId "2085451857" @default.
- W2085451857 workType "article" @default.