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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085451942> ?p ?o ?g. }

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• W2085451942 startingPage "482" @default.
• W2085451942 abstract "Multiple sclerosis (MS) is supposedly a T-cell mediated autoimmune disorder of the central nervous system. Cytokines and other molecules involved in the regulation of apoptosis are thought to be of importance for the pathogenesis of MS. In this study, the mRNA levels of interleukin 18 (IL-18), IL-1beta and their processing enzyme caspase-1 were quantified by a competitive RT-PCR method in unstimulated peripheral blood mononuclear cells (PBMCs) in MS patients never treated with disease modifying drugs. Western blot was used to support the expression pattern at the protein level. We found that the expression of caspase-1 and IL-18 was significantly increased in MS patients compared with healthy controls. Analysis of clinical subgroups revealed that caspase-1 was increased in all subgroups, whereas IL-18 was upregulated in chronic progression (P=0.001) and relapsing MS patients in remission (P=0.002) but not significantly during relapses (P=0.12). mRNA levels of IL-1beta were not significantly altered in MS except for a possible decrease in chronic progression (P=0.03). An increased IL-18 expression, potentially augmented at the mature protein level, may indicate a pathway worth considering in future therapeutic strategies in MS." @default.
• W2085451942 created "2016-06-24" @default.
• W2085451942 creator A5053300118 @default.
• W2085451942 creator A5061794399 @default.
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• W2085451942 date "2004-10-01" @default.
• W2085451942 modified "2023-10-08" @default.
• W2085451942 title "Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis" @default.
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• W2085451942 doi "https://doi.org/10.1191/1352458504ms1071oa" @default.
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