FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085452933> ?p ?o ?g. }

• W2085452933 endingPage "848" @default.
• W2085452933 startingPage "833" @default.
• W2085452933 abstract "Epigenetic modifications of histones regulate gene expression and lead to the establishment and maintenance of cellular phenotypes during development. Histone acetylation depends on a balance between the activities of histone acetyltransferases and histone deacetylases (HDACs) and influences transcriptional regulation. In this study, we analyse the roles of HDACs during growth and development of one of the cellular slime moulds, the social amoeba Dictyostelium discoideum. The inhibition of HDAC activity by trichostatin A results in histone hyperacetylation and a delay in cell aggregation and differentiation. Cyclic AMP oscillations are normal in starved amoebae treated with trichostatin A but the expression of a subset of cAMP-regulated genes is delayed. Bioinformatic analysis indicates that there are four genes encoding putative HDACs in D. discoideum. Using biochemical, genetic and developmental approaches, we demonstrate that one of these four genes, hdaB, is dispensable for growth and development under laboratory conditions. A knockout of the hdaB gene results in a social context-dependent phenotype: hdaB- cells develop normally but sporulate less efficiently than the wild type in chimeras. We infer that HDAC activity is important for regulating the timing of gene expression during the development of D. discoideum and for defining aspects of the phenotype that mediate social behaviour in genetically heterogeneous groups." @default.
• W2085452933 created "2016-06-24" @default.
• W2085452933 creator A5004337357 @default.
• W2085452933 creator A5011454358 @default.
• W2085452933 creator A5027255071 @default.
• W2085452933 creator A5033690391 @default.
• W2085452933 date "2009-09-01" @default.
• W2085452933 modified "2023-10-18" @default.
• W2085452933 title "Histone Deacetylases Regulate Multicellular Development in the Social Amoeba Dictyostelium discoideum" @default.
• W2085452933 cites W1147879691 @default.
• W2085452933 cites W1951165114 @default.
• W2085452933 cites W1971557910 @default.
• W2085452933 cites W1972347876 @default.
• W2085452933 cites W1977088975 @default.
• W2085452933 cites W1979519622 @default.
• W2085452933 cites W1990906967 @default.
• W2085452933 cites W1994637279 @default.
• W2085452933 cites W1997162894 @default.
• W2085452933 cites W2013547494 @default.
• W2085452933 cites W2023221086 @default.
• W2085452933 cites W2030907755 @default.
• W2085452933 cites W2033095962 @default.
• W2085452933 cites W2035631829 @default.
• W2085452933 cites W2037049502 @default.
• W2085452933 cites W2040506727 @default.
• W2085452933 cites W2041763314 @default.
• W2085452933 cites W2043148368 @default.
• W2085452933 cites W2052380505 @default.
• W2085452933 cites W2056800002 @default.
• W2085452933 cites W2062997824 @default.
• W2085452933 cites W2065420205 @default.
• W2085452933 cites W2066264051 @default.
• W2085452933 cites W2069183879 @default.
• W2085452933 cites W2069996888 @default.
• W2085452933 cites W2074308942 @default.
• W2085452933 cites W2078454854 @default.
• W2085452933 cites W2088279798 @default.
• W2085452933 cites W2089096062 @default.
• W2085452933 cites W2097337180 @default.
• W2085452933 cites W2099946731 @default.
• W2085452933 cites W2101870575 @default.
• W2085452933 cites W2101979121 @default.
• W2085452933 cites W2108017291 @default.
• W2085452933 cites W2112351720 @default.
• W2085452933 cites W2113032400 @default.
• W2085452933 cites W2120511487 @default.
• W2085452933 cites W2121168046 @default.
• W2085452933 cites W2127587233 @default.
• W2085452933 cites W2130005065 @default.
• W2085452933 cites W2135528772 @default.
• W2085452933 cites W2135830745 @default.
• W2085452933 cites W2137015675 @default.
• W2085452933 cites W2139872551 @default.
• W2085452933 cites W2144941081 @default.
• W2085452933 cites W2152631096 @default.
• W2085452933 cites W2156690217 @default.
• W2085452933 cites W2158747282 @default.
• W2085452933 cites W2162469705 @default.
• W2085452933 cites W2165532730 @default.
• W2085452933 cites W2168448928 @default.
• W2085452933 cites W4242066919 @default.
• W2085452933 cites W75928301 @default.
• W2085452933 doi "https://doi.org/10.1016/j.jmb.2009.06.067" @default.
• W2085452933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19576222" @default.
• W2085452933 hasPublicationYear "2009" @default.
• W2085452933 type Work @default.
• W2085452933 sameAs 2085452933 @default.
• W2085452933 citedByCount "15" @default.
• W2085452933 countsByYear W20854529332012 @default.
• W2085452933 countsByYear W20854529332013 @default.
• W2085452933 countsByYear W20854529332014 @default.
• W2085452933 countsByYear W20854529332015 @default.
• W2085452933 countsByYear W20854529332017 @default.
• W2085452933 countsByYear W20854529332020 @default.
• W2085452933 countsByYear W20854529332021 @default.
• W2085452933 countsByYear W20854529332022 @default.
• W2085452933 crossrefType "journal-article" @default.
• W2085452933 hasAuthorship W2085452933A5004337357 @default.
• W2085452933 hasAuthorship W2085452933A5011454358 @default.
• W2085452933 hasAuthorship W2085452933A5027255071 @default.
• W2085452933 hasAuthorship W2085452933A5033690391 @default.
• W2085452933 hasConcept C104317684 @default.
• W2085452933 hasConcept C119157956 @default.
• W2085452933 hasConcept C127716648 @default.
• W2085452933 hasConcept C150425827 @default.
• W2085452933 hasConcept C165864922 @default.
• W2085452933 hasConcept C2775889303 @default.
• W2085452933 hasConcept C2775969001 @default.
• W2085452933 hasConcept C2777865847 @default.
• W2085452933 hasConcept C2778305200 @default.
• W2085452933 hasConcept C2910921701 @default.
• W2085452933 hasConcept C41091548 @default.
• W2085452933 hasConcept C45946802 @default.
• W2085452933 hasConcept C54355233 @default.
• W2085452933 hasConcept C64927066 @default.
• W2085452933 hasConcept C74318829 @default.
• W2085452933 hasConcept C86803240 @default.
• W2085452933 hasConcept C95444343 @default.

• next