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• W2085454885 abstract "In a 12 week, placebo-controlled, parallel-design, multicenter study of sertraline for obsessive-compulsive disorder in 107 children and 80 adolescents, the authors prospectively assessed cardiovascular effects to doses of sertraline of < or = 200 mg/day.Vital signs (blood pressure and heart rate) and electrocardiograph parameters (ECGs) were systematically evaluated at baseline and again throughout treatment.There were no clinically significant cardiovascular adverse events in any of the subjects enrolled in the study. Moreover, compared with baseline and placebo, sertraline treatment at an average dose of 167 mg did not result in any clinically meaningful changes in any ECG indices (PR, QRS, and QTc intervals), cardiac rhythm, blood pressure, or heart rate.These prospectively derived results support the cardiovascular safety of sertraline at doses up to 200 mg in children and adolescents." @default.
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• W2085454885 date "1999-05-01" @default.
• W2085454885 modified "2023-09-27" @default.
• W2085454885 title "Absence of Cardiovascular Adverse Effects of Sertraline in Children and Adolescents" @default.
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• W2085454885 doi "https://doi.org/10.1097/00004583-199905000-00019" @default.
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