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- W2085456081 abstract "The yeast chromosomal genes SK12, SK13, SK14, SK16, SK17 and SK18 repress the replication of double-stranded RNA viruses, protecting the host from the otherwise lethal effects of the virus. We cloned and sequenced the SK13 gene and found that it encodes a 163 kDa protein including a typical nuclear localization signal. Cell fractionation experiments show that the SK13 gene product is indeed tightly associated with nuclei and that the putative nuclear localization sequence directs β-galactosidase into the nucleus. However, fusion of a part of the SK13 protein lacking this signal with β-galactosidase directs β-galactosidase into the nucleus, suggesting the presence of a second nuclear localization signal. The SK13 gene is only essential in the presence of an M double-stranded RNA virus." @default.
- W2085456081 created "2016-06-24" @default.
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- W2085456081 date "1989-05-01" @default.
- W2085456081 modified "2023-10-17" @default.
- W2085456081 title "Structure and nuclear localization signal of the SK13 antiviral protein ofSaccharomyces cerevisiae" @default.
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- W2085456081 doi "https://doi.org/10.1002/yea.320050304" @default.
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