FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085457170> ?p ?o ?g. }

• W2085457170 endingPage "e607" @default.
• W2085457170 startingPage "e607" @default.
• W2085457170 abstract "Commitment of differentiating embryonic stem cells (ESCs) toward the various lineages is influenced by many factors, including androgens. However, the mechanisms underlying proteotoxic stress conferred by androgen receptor (AR) actions on embryonic cell fate remains unclear. Here we show that mouse ESCs display stress-related cellular phenotypes in response to androgens during early phase of differentiation. Androgen induced a significant increase in the percentage of ESCs and embryoid bodies with the intranuclear and juxtanuclear AR inclusions, which were colocalized with the E3 ubiquitin ligase, C terminus of Hsc70-interacting protein. Caspase-3 activity corresponded with AR expression, was enhanced in cells engaged more differentiation phenotypes. Androgen-mediated accumulation of AR aggregates exacerbated endoplasmic reticulum (ER) stress and rendered ESCs susceptible to apoptosis. Increasing expression levels of the ER chaperones, GRP78/BiP and GRP94, as well as ER stress markers, such as ATF6, phosphorylated PERK, GADD153/CHOP and spliced XBP-1 mRNA, were dramatically elevated in ESCs overexpressing AR. We found that androgen induced GRP78/BiP to dissociate from ATF6, and act as an AR-interacting protein, which was recruited into AR inclusions in ESCs. GRP78/BiP was also colocalized with AR inclusions in the cells of spinal bulbar muscular atrophy transgenic mouse model. Overexpression of GRP78/BiP suppressed ubiquitination of AR aggregates and ameliorated the misfolded AR-mediated cytopathology in ESCs, whereas knockdown of GRP78/BiP increased the accumulation of AR aggregates and significantly higher levels of caspase-3 activity and cell apoptosis. These results generate novel insight into how ESCs respond to stress induced by misfolded AR proteins and identify GRP78/BiP as a novel regulator of the AR protein quality control." @default.
• W2085457170 created "2016-06-24" @default.
• W2085457170 creator A5026496892 @default.
• W2085457170 creator A5029337859 @default.
• W2085457170 creator A5038615752 @default.
• W2085457170 creator A5045535997 @default.
• W2085457170 creator A5048034742 @default.
• W2085457170 creator A5053115215 @default.
• W2085457170 creator A5053297767 @default.
• W2085457170 creator A5057636273 @default.
• W2085457170 creator A5057790039 @default.
• W2085457170 creator A5076626440 @default.
• W2085457170 creator A5083492238 @default.
• W2085457170 date "2013-04-25" @default.
• W2085457170 modified "2023-10-08" @default.
• W2085457170 title "Androgen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cells" @default.
• W2085457170 cites W1602776657 @default.
• W2085457170 cites W1604791477 @default.
• W2085457170 cites W1617816798 @default.
• W2085457170 cites W1968874378 @default.
• W2085457170 cites W1976161806 @default.
• W2085457170 cites W1977644279 @default.
• W2085457170 cites W1979193480 @default.
• W2085457170 cites W1986422550 @default.
• W2085457170 cites W1988482079 @default.
• W2085457170 cites W1994796679 @default.
• W2085457170 cites W1996785364 @default.
• W2085457170 cites W1997369314 @default.
• W2085457170 cites W1998982625 @default.
• W2085457170 cites W2002431899 @default.
• W2085457170 cites W2008751481 @default.
• W2085457170 cites W2025125702 @default.
• W2085457170 cites W2025714022 @default.
• W2085457170 cites W2033890667 @default.
• W2085457170 cites W2035826838 @default.
• W2085457170 cites W2038120434 @default.
• W2085457170 cites W2038507667 @default.
• W2085457170 cites W2043825401 @default.
• W2085457170 cites W2044155146 @default.
• W2085457170 cites W2056867819 @default.
• W2085457170 cites W2073182617 @default.
• W2085457170 cites W2076759214 @default.
• W2085457170 cites W2077669777 @default.
• W2085457170 cites W2078618741 @default.
• W2085457170 cites W2079196978 @default.
• W2085457170 cites W2091875431 @default.
• W2085457170 cites W2100347985 @default.
• W2085457170 cites W2106786078 @default.
• W2085457170 cites W2121751048 @default.
• W2085457170 cites W2123431154 @default.
• W2085457170 cites W2124733101 @default.
• W2085457170 cites W2126496338 @default.
• W2085457170 cites W2132296982 @default.
• W2085457170 cites W2139396663 @default.
• W2085457170 cites W2154445158 @default.
• W2085457170 cites W2159466552 @default.
• W2085457170 cites W2161123101 @default.
• W2085457170 cites W2163411496 @default.
• W2085457170 doi "https://doi.org/10.1038/cddis.2013.122" @default.
• W2085457170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3641345" @default.
• W2085457170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23618905" @default.
• W2085457170 hasPublicationYear "2013" @default.
• W2085457170 type Work @default.
• W2085457170 sameAs 2085457170 @default.
• W2085457170 citedByCount "18" @default.
• W2085457170 countsByYear W20854571702014 @default.
• W2085457170 countsByYear W20854571702015 @default.
• W2085457170 countsByYear W20854571702016 @default.
• W2085457170 countsByYear W20854571702017 @default.
• W2085457170 countsByYear W20854571702018 @default.
• W2085457170 countsByYear W20854571702020 @default.
• W2085457170 countsByYear W20854571702021 @default.
• W2085457170 countsByYear W20854571702022 @default.
• W2085457170 crossrefType "journal-article" @default.
• W2085457170 hasAuthorship W2085457170A5026496892 @default.
• W2085457170 hasAuthorship W2085457170A5029337859 @default.
• W2085457170 hasAuthorship W2085457170A5038615752 @default.
• W2085457170 hasAuthorship W2085457170A5045535997 @default.
• W2085457170 hasAuthorship W2085457170A5048034742 @default.
• W2085457170 hasAuthorship W2085457170A5053115215 @default.
• W2085457170 hasAuthorship W2085457170A5053297767 @default.
• W2085457170 hasAuthorship W2085457170A5057636273 @default.
• W2085457170 hasAuthorship W2085457170A5057790039 @default.
• W2085457170 hasAuthorship W2085457170A5076626440 @default.
• W2085457170 hasAuthorship W2085457170A5083492238 @default.
• W2085457170 hasBestOaLocation W20854571701 @default.
• W2085457170 hasConcept C104317684 @default.
• W2085457170 hasConcept C107459253 @default.
• W2085457170 hasConcept C121608353 @default.
• W2085457170 hasConcept C134459356 @default.
• W2085457170 hasConcept C139447449 @default.
• W2085457170 hasConcept C143948831 @default.
• W2085457170 hasConcept C145103041 @default.
• W2085457170 hasConcept C158617107 @default.
• W2085457170 hasConcept C25602115 @default.
• W2085457170 hasConcept C2778997996 @default.
• W2085457170 hasConcept C2780192828 @default.
• W2085457170 hasConcept C54355233 @default.

• next