FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085457897> ?p ?o ?g. }

• W2085457897 endingPage "211" @default.
• W2085457897 startingPage "211" @default.
• W2085457897 abstract "cDNA species coding for novel variants of cyclic-AMP-specific phosphodiesterases (PDEs), namely the PDE7B family, were isolated from rats and characterized. Rat PDE7B1 (RNPDE7B1) was composed of 446 amino acid residues. Rat PDE7B2 (RNPDE7B2) and PDE7B3 (RNPDE7B3), which possessed unique N-terminal sequences, consisted of 359 and 459 residues respectively. Northern hybridization analysis showed that rat PDE7B transcripts were particularly abundant in the striatum and testis. PCR analyses revealed that rat PDE7B2 transcripts were restricted to the testis and that low levels of PDE7B3 transcripts were expressed in the heart, lung and skeletal muscle. In situ hybridization analysis demonstrated that rat PDE7B transcripts were expressed in striatal neurons and spermatocytes. In spermatocytes, rat PDE7B transcripts were expressed in a stage-specific manner during spermatogenesis. The K(m) values of recombinant rat PDE7B1, PDE7B2 and PDE7B3 for cAMP were 0.05, 0.07 and 0.05 microM respectively. Each rat PDE7B variant was the most sensitive to 3-isobutyl-1-methylxanthine (IC(50) 1.5-2.1 microM). Two phosphorylation sites for cAMP-dependent protein kinase (PKA) were found in rat PDE7B1 and PDE7B3, whereas rat PDE7B2 possessed one site. PKA-dependent phosphorylation was observed in C-terminal phosphorylation sites of three rat PDE7B variants, in addition to unique N-terminal regions of rat PDE7B1 and PDE7B3. Unique tissue distribution and PKA-dependent phosphorylation of PDE7B variants suggested that each variant has a specific role for cellular functions via cAMP signalling in various tissues." @default.
• W2085457897 created "2016-06-24" @default.
• W2085457897 creator A5004788764 @default.
• W2085457897 creator A5005406149 @default.
• W2085457897 creator A5046929164 @default.
• W2085457897 date "2002-01-15" @default.
• W2085457897 modified "2023-09-26" @default.
• W2085457897 title "Novel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-specific expression and phosphorylation" @default.
• W2085457897 cites W1522478928 @default.
• W2085457897 cites W1524509448 @default.
• W2085457897 cites W1543655975 @default.
• W2085457897 cites W1604404976 @default.
• W2085457897 cites W1964956351 @default.
• W2085457897 cites W1967220625 @default.
• W2085457897 cites W1967882515 @default.
• W2085457897 cites W1968189883 @default.
• W2085457897 cites W1970335747 @default.
• W2085457897 cites W1972608995 @default.
• W2085457897 cites W1974744486 @default.
• W2085457897 cites W1975769625 @default.
• W2085457897 cites W1977533543 @default.
• W2085457897 cites W1983735042 @default.
• W2085457897 cites W1986782732 @default.
• W2085457897 cites W1993171057 @default.
• W2085457897 cites W1996571204 @default.
• W2085457897 cites W1997752494 @default.
• W2085457897 cites W2008704486 @default.
• W2085457897 cites W2016612181 @default.
• W2085457897 cites W2018289835 @default.
• W2085457897 cites W2020174502 @default.
• W2085457897 cites W2035690299 @default.
• W2085457897 cites W2037261940 @default.
• W2085457897 cites W2038175531 @default.
• W2085457897 cites W2039812666 @default.
• W2085457897 cites W2046406719 @default.
• W2085457897 cites W2046493195 @default.
• W2085457897 cites W2046648030 @default.
• W2085457897 cites W2056147576 @default.
• W2085457897 cites W2066880490 @default.
• W2085457897 cites W2070218247 @default.
• W2085457897 cites W2088763860 @default.
• W2085457897 cites W2089338632 @default.
• W2085457897 cites W2093343991 @default.
• W2085457897 cites W2100837269 @default.
• W2085457897 cites W2106393844 @default.
• W2085457897 cites W2106753244 @default.
• W2085457897 cites W2121401190 @default.
• W2085457897 cites W2166389885 @default.
• W2085457897 cites W2170453612 @default.
• W2085457897 cites W2180410797 @default.
• W2085457897 cites W2402700043 @default.
• W2085457897 cites W264936362 @default.
• W2085457897 doi "https://doi.org/10.1042/0264-6021:3610211" @default.
• W2085457897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1222301" @default.
• W2085457897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11772393" @default.
• W2085457897 hasPublicationYear "2002" @default.
• W2085457897 type Work @default.
• W2085457897 sameAs 2085457897 @default.
• W2085457897 citedByCount "36" @default.
• W2085457897 countsByYear W20854578972012 @default.
• W2085457897 countsByYear W20854578972014 @default.
• W2085457897 countsByYear W20854578972017 @default.
• W2085457897 countsByYear W20854578972019 @default.
• W2085457897 countsByYear W20854578972021 @default.
• W2085457897 countsByYear W20854578972023 @default.
• W2085457897 crossrefType "journal-article" @default.
• W2085457897 hasAuthorship W2085457897A5004788764 @default.
• W2085457897 hasAuthorship W2085457897A5005406149 @default.
• W2085457897 hasAuthorship W2085457897A5046929164 @default.
• W2085457897 hasBestOaLocation W20854578972 @default.
• W2085457897 hasConcept C104317684 @default.
• W2085457897 hasConcept C105580179 @default.
• W2085457897 hasConcept C11960822 @default.
• W2085457897 hasConcept C153911025 @default.
• W2085457897 hasConcept C181199279 @default.
• W2085457897 hasConcept C187882448 @default.
• W2085457897 hasConcept C194583182 @default.
• W2085457897 hasConcept C55493867 @default.
• W2085457897 hasConcept C62826618 @default.
• W2085457897 hasConcept C81439078 @default.
• W2085457897 hasConcept C86803240 @default.
• W2085457897 hasConcept C97029542 @default.
• W2085457897 hasConceptScore W2085457897C104317684 @default.
• W2085457897 hasConceptScore W2085457897C105580179 @default.
• W2085457897 hasConceptScore W2085457897C11960822 @default.
• W2085457897 hasConceptScore W2085457897C153911025 @default.
• W2085457897 hasConceptScore W2085457897C181199279 @default.
• W2085457897 hasConceptScore W2085457897C187882448 @default.
• W2085457897 hasConceptScore W2085457897C194583182 @default.
• W2085457897 hasConceptScore W2085457897C55493867 @default.
• W2085457897 hasConceptScore W2085457897C62826618 @default.
• W2085457897 hasConceptScore W2085457897C81439078 @default.
• W2085457897 hasConceptScore W2085457897C86803240 @default.
• W2085457897 hasConceptScore W2085457897C97029542 @default.
• W2085457897 hasIssue "2" @default.
• W2085457897 hasLocation W20854578971 @default.
• W2085457897 hasLocation W20854578972 @default.
• W2085457897 hasLocation W20854578973 @default.

• next