Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085457955> ?p ?o ?g. }
- W2085457955 endingPage "460" @default.
- W2085457955 startingPage "454" @default.
- W2085457955 abstract "Twist1 is a transcription factor that is involved in epithelial–mesenchymal transition by suppressing intercellular adhesion. In this study, we aimed to determine the role of Twist1 in the regulation of claudin-4 expression and investigate its specific mechanisms and clinical implications using human esophageal carcinoma cell lines and tissues. As a result, up-regulation of Twist1 decreased both gene and protein expression levels of endogenous claudin-4 and the suppression was mediated by direct binding of Twist1 to the canonical E-box in the promoter region of claudin-4. In addition, there was a significant inverse correlation of claudin-4 with Twist1 in esophageal cancer tissues. High Twist1 and low claudin-4 expression was associated with the poorest prognosis and was more highly correlated with adverse outcome than any other subgroup with statistical significance (p = 0.001). Our results indicate that Twist1 induces the repression of claudin-4 expression during the epithelial–mesenchymal transition in esophageal carcinoma." @default.
- W2085457955 created "2016-06-24" @default.
- W2085457955 creator A5014332815 @default.
- W2085457955 creator A5034774599 @default.
- W2085457955 creator A5046140288 @default.
- W2085457955 creator A5048738472 @default.
- W2085457955 creator A5049243607 @default.
- W2085457955 creator A5057695550 @default.
- W2085457955 creator A5085895617 @default.
- W2085457955 creator A5089297064 @default.
- W2085457955 date "2012-07-01" @default.
- W2085457955 modified "2023-10-06" @default.
- W2085457955 title "Twist1 causes the transcriptional repression of claudin-4 with prognostic significance in esophageal cancer" @default.
- W2085457955 cites W1603169147 @default.
- W2085457955 cites W1987473368 @default.
- W2085457955 cites W1999044981 @default.
- W2085457955 cites W2009410973 @default.
- W2085457955 cites W2012117840 @default.
- W2085457955 cites W2021433913 @default.
- W2085457955 cites W2036008499 @default.
- W2085457955 cites W2036123840 @default.
- W2085457955 cites W2042198997 @default.
- W2085457955 cites W2051940224 @default.
- W2085457955 cites W2053195947 @default.
- W2085457955 cites W2058799146 @default.
- W2085457955 cites W2063011414 @default.
- W2085457955 cites W2063407256 @default.
- W2085457955 cites W2066672392 @default.
- W2085457955 cites W2074149867 @default.
- W2085457955 cites W2079482620 @default.
- W2085457955 cites W2091720415 @default.
- W2085457955 cites W2107277218 @default.
- W2085457955 cites W2155619409 @default.
- W2085457955 cites W2159526033 @default.
- W2085457955 cites W2161858650 @default.
- W2085457955 cites W2170505336 @default.
- W2085457955 cites W2292911347 @default.
- W2085457955 doi "https://doi.org/10.1016/j.bbrc.2012.05.140" @default.
- W2085457955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22668877" @default.
- W2085457955 hasPublicationYear "2012" @default.
- W2085457955 type Work @default.
- W2085457955 sameAs 2085457955 @default.
- W2085457955 citedByCount "20" @default.
- W2085457955 countsByYear W20854579552012 @default.
- W2085457955 countsByYear W20854579552013 @default.
- W2085457955 countsByYear W20854579552014 @default.
- W2085457955 countsByYear W20854579552015 @default.
- W2085457955 countsByYear W20854579552017 @default.
- W2085457955 countsByYear W20854579552021 @default.
- W2085457955 countsByYear W20854579552023 @default.
- W2085457955 crossrefType "journal-article" @default.
- W2085457955 hasAuthorship W2085457955A5014332815 @default.
- W2085457955 hasAuthorship W2085457955A5034774599 @default.
- W2085457955 hasAuthorship W2085457955A5046140288 @default.
- W2085457955 hasAuthorship W2085457955A5048738472 @default.
- W2085457955 hasAuthorship W2085457955A5049243607 @default.
- W2085457955 hasAuthorship W2085457955A5057695550 @default.
- W2085457955 hasAuthorship W2085457955A5085895617 @default.
- W2085457955 hasAuthorship W2085457955A5089297064 @default.
- W2085457955 hasConcept C104317684 @default.
- W2085457955 hasConcept C121608353 @default.
- W2085457955 hasConcept C126322002 @default.
- W2085457955 hasConcept C142724271 @default.
- W2085457955 hasConcept C150194340 @default.
- W2085457955 hasConcept C16613235 @default.
- W2085457955 hasConcept C177779419 @default.
- W2085457955 hasConcept C186310378 @default.
- W2085457955 hasConcept C194232998 @default.
- W2085457955 hasConcept C2778893926 @default.
- W2085457955 hasConcept C2779742542 @default.
- W2085457955 hasConcept C502942594 @default.
- W2085457955 hasConcept C51872919 @default.
- W2085457955 hasConcept C54355233 @default.
- W2085457955 hasConcept C71924100 @default.
- W2085457955 hasConcept C76419328 @default.
- W2085457955 hasConcept C86339819 @default.
- W2085457955 hasConcept C86803240 @default.
- W2085457955 hasConcept C95444343 @default.
- W2085457955 hasConceptScore W2085457955C104317684 @default.
- W2085457955 hasConceptScore W2085457955C121608353 @default.
- W2085457955 hasConceptScore W2085457955C126322002 @default.
- W2085457955 hasConceptScore W2085457955C142724271 @default.
- W2085457955 hasConceptScore W2085457955C150194340 @default.
- W2085457955 hasConceptScore W2085457955C16613235 @default.
- W2085457955 hasConceptScore W2085457955C177779419 @default.
- W2085457955 hasConceptScore W2085457955C186310378 @default.
- W2085457955 hasConceptScore W2085457955C194232998 @default.
- W2085457955 hasConceptScore W2085457955C2778893926 @default.
- W2085457955 hasConceptScore W2085457955C2779742542 @default.
- W2085457955 hasConceptScore W2085457955C502942594 @default.
- W2085457955 hasConceptScore W2085457955C51872919 @default.
- W2085457955 hasConceptScore W2085457955C54355233 @default.
- W2085457955 hasConceptScore W2085457955C71924100 @default.
- W2085457955 hasConceptScore W2085457955C76419328 @default.
- W2085457955 hasConceptScore W2085457955C86339819 @default.
- W2085457955 hasConceptScore W2085457955C86803240 @default.
- W2085457955 hasConceptScore W2085457955C95444343 @default.
- W2085457955 hasIssue "3" @default.