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• W2085459563 abstract "The thermolabile variant (677TT) of methylenetetrahydrofolate reductase (MTHFR) is a known risk factor for neural tube defects (NTDs). The relationship between a second MTHFR polymorphism (1298A-->C) and NTD risk has been inconsistent between studies. We genotyped 276 complete NTD triads (mother, father and child affected with an NTD) and 256 controls for MTHFR 1298A-->C. Our findings do not support a role for the 1298A-->C polymorphism in NTDs (OR 0.85 (95% CI 0.49-1.47), p= 0.55), nor do we observe a combined effect with the 677C-->T polymorphism." @default.
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• W2085459563 date "2003-03-05" @default.
• W2085459563 modified "2023-10-15" @default.
• W2085459563 title "Analysis of the MTHFR 1298A→C and 677C→T polymorphisms as risk factors for neural tube defects" @default.
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• W2085459563 doi "https://doi.org/10.1007/s10038-003-0008-4" @default.
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