FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085459927> ?p ?o ?g. }

• W2085459927 endingPage "35420" @default.
• W2085459927 startingPage "35409" @default.
• W2085459927 abstract "SIRT1, a class III histone deacetylase, protects neurons in various models of neurodegenerative diseases. We previously described that neuroprotection by SIRT1 is independent of its catalytic activity. To elucidate how SIRT1 protects neurons, we performed a mass spectrometric screen to find SIRT1-interacting proteins. One of the proteins identified was JAZ (Znf346), a member of a new class of Cys-2-His-2 zinc finger proteins. To investigate the significance of JAZ in the regulation of neuronal survival, we overexpressed it in neurons. We found that JAZ protects cerebellar granule neurons against potassium deprivation-induced death and cortical neurons from death resulting from oxidative stress. JAZ also protects neurons against toxicity induced by mutant huntingtin and mutant ataxin-1 expression. Although expression of endogenous JAZ does not change in neurons primed to die, knockdown of its expression promotes death of otherwise healthy neurons. In contrast to its protective effect in neurons, overexpression of JAZ in different cell lines promotes death. We find that JAZ suppresses cell cycle progression, thereby explaining its contrasting effect in postmitotic neurons versus proliferating cell lines. Although not affecting the expression of several cyclins, overexpression of JAZ stimulates expression of p21 (WAF1/CIP1), a cell cycle inhibitor known to have neuroprotective effects. Results of chromatin immunoprecipitation and transcriptional assays indicate that the stimulatory effect of JAZ on p21 expression is mediated at the transcriptional level. Furthermore, knockdown of p21 expression inhibits the neuroprotective effect of JAZ. Together, our results suggest that JAZ protects neurons by inhibiting cell cycle re-entry through the transcriptional stimulation of p21 expression." @default.
• W2085459927 created "2016-06-24" @default.
• W2085459927 creator A5028628379 @default.
• W2085459927 creator A5040464161 @default.
• W2085459927 date "2014-12-01" @default.
• W2085459927 modified "2023-10-06" @default.
• W2085459927 title "JAZ (Znf346), a SIRT1-interacting Protein, Protects Neurons by Stimulating p21 (WAF/CIP1) Protein Expression" @default.
• W2085459927 cites W1969308639 @default.
• W2085459927 cites W1976967262 @default.
• W2085459927 cites W1978323928 @default.
• W2085459927 cites W1978511426 @default.
• W2085459927 cites W1979807466 @default.
• W2085459927 cites W1984093745 @default.
• W2085459927 cites W1984917111 @default.
• W2085459927 cites W1994318923 @default.
• W2085459927 cites W2002468355 @default.
• W2085459927 cites W2016301178 @default.
• W2085459927 cites W2018183560 @default.
• W2085459927 cites W2024861994 @default.
• W2085459927 cites W2027112793 @default.
• W2085459927 cites W2028466753 @default.
• W2085459927 cites W2029862426 @default.
• W2085459927 cites W2030090792 @default.
• W2085459927 cites W2036903341 @default.
• W2085459927 cites W2040400202 @default.
• W2085459927 cites W2053776819 @default.
• W2085459927 cites W2063612483 @default.
• W2085459927 cites W2065691470 @default.
• W2085459927 cites W2066545507 @default.
• W2085459927 cites W2071753279 @default.
• W2085459927 cites W2072286244 @default.
• W2085459927 cites W2073943727 @default.
• W2085459927 cites W2097607289 @default.
• W2085459927 cites W2112227403 @default.
• W2085459927 cites W2129434315 @default.
• W2085459927 cites W2130946797 @default.
• W2085459927 cites W2145278696 @default.
• W2085459927 cites W2147887491 @default.
• W2085459927 cites W2153333653 @default.
• W2085459927 cites W2164627879 @default.
• W2085459927 cites W2165368743 @default.
• W2085459927 cites W2328091064 @default.
• W2085459927 doi "https://doi.org/10.1074/jbc.m114.597575" @default.
• W2085459927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4271226" @default.
• W2085459927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25331946" @default.
• W2085459927 hasPublicationYear "2014" @default.
• W2085459927 type Work @default.
• W2085459927 sameAs 2085459927 @default.
• W2085459927 citedByCount "14" @default.
• W2085459927 countsByYear W20854599272015 @default.
• W2085459927 countsByYear W20854599272016 @default.
• W2085459927 countsByYear W20854599272017 @default.
• W2085459927 countsByYear W20854599272018 @default.
• W2085459927 countsByYear W20854599272019 @default.
• W2085459927 countsByYear W20854599272020 @default.
• W2085459927 countsByYear W20854599272021 @default.
• W2085459927 countsByYear W20854599272022 @default.
• W2085459927 countsByYear W20854599272023 @default.
• W2085459927 crossrefType "journal-article" @default.
• W2085459927 hasAuthorship W2085459927A5028628379 @default.
• W2085459927 hasAuthorship W2085459927A5040464161 @default.
• W2085459927 hasBestOaLocation W20854599271 @default.
• W2085459927 hasConcept C101762097 @default.
• W2085459927 hasConcept C104317684 @default.
• W2085459927 hasConcept C134320426 @default.
• W2085459927 hasConcept C150194340 @default.
• W2085459927 hasConcept C158448853 @default.
• W2085459927 hasConcept C169760540 @default.
• W2085459927 hasConcept C173396325 @default.
• W2085459927 hasConcept C185592680 @default.
• W2085459927 hasConcept C190283241 @default.
• W2085459927 hasConcept C25498285 @default.
• W2085459927 hasConcept C31573885 @default.
• W2085459927 hasConcept C54355233 @default.
• W2085459927 hasConcept C55493867 @default.
• W2085459927 hasConcept C81885089 @default.
• W2085459927 hasConcept C86339819 @default.
• W2085459927 hasConcept C86803240 @default.
• W2085459927 hasConcept C95444343 @default.
• W2085459927 hasConceptScore W2085459927C101762097 @default.
• W2085459927 hasConceptScore W2085459927C104317684 @default.
• W2085459927 hasConceptScore W2085459927C134320426 @default.
• W2085459927 hasConceptScore W2085459927C150194340 @default.
• W2085459927 hasConceptScore W2085459927C158448853 @default.
• W2085459927 hasConceptScore W2085459927C169760540 @default.
• W2085459927 hasConceptScore W2085459927C173396325 @default.
• W2085459927 hasConceptScore W2085459927C185592680 @default.
• W2085459927 hasConceptScore W2085459927C190283241 @default.
• W2085459927 hasConceptScore W2085459927C25498285 @default.
• W2085459927 hasConceptScore W2085459927C31573885 @default.
• W2085459927 hasConceptScore W2085459927C54355233 @default.
• W2085459927 hasConceptScore W2085459927C55493867 @default.
• W2085459927 hasConceptScore W2085459927C81885089 @default.
• W2085459927 hasConceptScore W2085459927C86339819 @default.
• W2085459927 hasConceptScore W2085459927C86803240 @default.
• W2085459927 hasConceptScore W2085459927C95444343 @default.
• W2085459927 hasFunder F4320332161 @default.
• W2085459927 hasIssue "51" @default.

• next