Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085460082> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2085460082 endingPage "1561" @default.
- W2085460082 startingPage "1561" @default.
- W2085460082 abstract "Studies on the metabolic disposition of ciramadol, a new orally effective analgesic, have been conducted in the rhesus monkey and male rat. The drug is well absorbed but undergoes extensive presystemic metabolism when given by the intragastric route (1 mg/kg) to rhesus monkeys. Maximum concentrations in plasma do not exceed 4 ng/ml. The major transformation occurs by glucuronidation and leads to two metabolites, and aryl O- and an alicyclic O-glucuronide. Phase I transformations are apparently minor and include N-demethylation, formation of benzoxazinyl metabolites from the reaction of endogenous acetaldehyde and formaldehyde with N-desmethylciramadol, and oxidation of the alicyclic and aromatic rings. Mass-spectrometric analyses of the isolated glucuronides and the minor phase I metabolites have been employed for structural assignments. Excretion of the intragastric dose occurs predominantly by the renal route. When given intramuscularly (1 mg/kg), concentrations of ciramadol peak at 1150 ng/ml by 0.5 hr after medication and decline rapidly to less than 7 ng/ml by 8 hr. Approximately 10% of the dose is excreted as unchanged ciramadol after im dosing. In male rats, the drug is absorbed rapidly after single 1-mg/kg intragastric doses and is taken up notably by liver, lung, kidney and spleen. Unlike its disposition in rhesus monkeys, ciramadol is present in plasma and excreted into urine mainly in the unconjugated form. Concentrations of drug in rat plasma are higher than those in rhesus monkey plasma, suggesting a smaller first-pass effect in the rat." @default.
- W2085460082 created "2016-06-24" @default.
- W2085460082 creator A5000147775 @default.
- W2085460082 creator A5046509454 @default.
- W2085460082 creator A5069457755 @default.
- W2085460082 creator A5074526208 @default.
- W2085460082 date "1986-06-14" @default.
- W2085460082 modified "2023-09-26" @default.
- W2085460082 title "Asthma caused by pulverised fuel ash." @default.
- W2085460082 cites W2049239278 @default.
- W2085460082 cites W2065273992 @default.
- W2085460082 cites W2164889989 @default.
- W2085460082 cites W2339764534 @default.
- W2085460082 doi "https://doi.org/10.1136/bmj.292.6535.1561" @default.
- W2085460082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1340562" @default.
- W2085460082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3087518" @default.
- W2085460082 hasPublicationYear "1986" @default.
- W2085460082 type Work @default.
- W2085460082 sameAs 2085460082 @default.
- W2085460082 citedByCount "5" @default.
- W2085460082 countsByYear W20854600822017 @default.
- W2085460082 countsByYear W20854600822019 @default.
- W2085460082 countsByYear W20854600822020 @default.
- W2085460082 crossrefType "journal-article" @default.
- W2085460082 hasAuthorship W2085460082A5000147775 @default.
- W2085460082 hasAuthorship W2085460082A5046509454 @default.
- W2085460082 hasAuthorship W2085460082A5069457755 @default.
- W2085460082 hasAuthorship W2085460082A5074526208 @default.
- W2085460082 hasBestOaLocation W20854600821 @default.
- W2085460082 hasConcept C10146269 @default.
- W2085460082 hasConcept C112705442 @default.
- W2085460082 hasConcept C126322002 @default.
- W2085460082 hasConcept C134018914 @default.
- W2085460082 hasConcept C181199279 @default.
- W2085460082 hasConcept C185592680 @default.
- W2085460082 hasConcept C2775922563 @default.
- W2085460082 hasConcept C2777056448 @default.
- W2085460082 hasConcept C2777477808 @default.
- W2085460082 hasConcept C2777595113 @default.
- W2085460082 hasConcept C2779186261 @default.
- W2085460082 hasConcept C2779907587 @default.
- W2085460082 hasConcept C2780026642 @default.
- W2085460082 hasConcept C2780161600 @default.
- W2085460082 hasConcept C43617362 @default.
- W2085460082 hasConcept C55493867 @default.
- W2085460082 hasConcept C62231903 @default.
- W2085460082 hasConcept C71924100 @default.
- W2085460082 hasConcept C87644729 @default.
- W2085460082 hasConcept C89311334 @default.
- W2085460082 hasConcept C98274493 @default.
- W2085460082 hasConceptScore W2085460082C10146269 @default.
- W2085460082 hasConceptScore W2085460082C112705442 @default.
- W2085460082 hasConceptScore W2085460082C126322002 @default.
- W2085460082 hasConceptScore W2085460082C134018914 @default.
- W2085460082 hasConceptScore W2085460082C181199279 @default.
- W2085460082 hasConceptScore W2085460082C185592680 @default.
- W2085460082 hasConceptScore W2085460082C2775922563 @default.
- W2085460082 hasConceptScore W2085460082C2777056448 @default.
- W2085460082 hasConceptScore W2085460082C2777477808 @default.
- W2085460082 hasConceptScore W2085460082C2777595113 @default.
- W2085460082 hasConceptScore W2085460082C2779186261 @default.
- W2085460082 hasConceptScore W2085460082C2779907587 @default.
- W2085460082 hasConceptScore W2085460082C2780026642 @default.
- W2085460082 hasConceptScore W2085460082C2780161600 @default.
- W2085460082 hasConceptScore W2085460082C43617362 @default.
- W2085460082 hasConceptScore W2085460082C55493867 @default.
- W2085460082 hasConceptScore W2085460082C62231903 @default.
- W2085460082 hasConceptScore W2085460082C71924100 @default.
- W2085460082 hasConceptScore W2085460082C87644729 @default.
- W2085460082 hasConceptScore W2085460082C89311334 @default.
- W2085460082 hasConceptScore W2085460082C98274493 @default.
- W2085460082 hasIssue "6535" @default.
- W2085460082 hasLocation W20854600821 @default.
- W2085460082 hasLocation W20854600822 @default.
- W2085460082 hasLocation W20854600823 @default.
- W2085460082 hasLocation W20854600824 @default.
- W2085460082 hasOpenAccess W2085460082 @default.
- W2085460082 hasPrimaryLocation W20854600821 @default.
- W2085460082 hasRelatedWork W1993029667 @default.
- W2085460082 hasRelatedWork W1995722928 @default.
- W2085460082 hasRelatedWork W2045937169 @default.
- W2085460082 hasRelatedWork W2062195390 @default.
- W2085460082 hasRelatedWork W2071770316 @default.
- W2085460082 hasRelatedWork W2333539998 @default.
- W2085460082 hasRelatedWork W2406801323 @default.
- W2085460082 hasRelatedWork W2430409124 @default.
- W2085460082 hasRelatedWork W2913396374 @default.
- W2085460082 hasRelatedWork W2485882805 @default.
- W2085460082 hasVolume "292" @default.
- W2085460082 isParatext "false" @default.
- W2085460082 isRetracted "false" @default.
- W2085460082 magId "2085460082" @default.
- W2085460082 workType "article" @default.