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- W2085465052 abstract "Epigenetics, the heritable changes that do not involve DNA sequences, give dynamic propulsion to a static genome and modulate genome accessibility by acting through multiple layers of regulation, ultimately ending with a variable organization of chromatin. The main player in chromatin reprograming is the nucleosome, which modifies its association to DNA depending on a variety of post-translational modifications (PTMs) on histone tails. PTMs act directly on higher order chromatin structures and affect the degree of DNA wrap around the histone octamer and the interaction and/or sequential recruitment of chromatin-associated proteins and transcription factors at defined regions. Recently genomic approaches revealed a far more complex epigenome involving key proteins of cell signaling." @default.
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- W2085465052 date "2010-02-16" @default.
- W2085465052 modified "2023-09-27" @default.
- W2085465052 title "Tuning acetylated chromatin with HAT inhibitors: A novel tool for therapy" @default.
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- W2085465052 doi "https://doi.org/10.4161/epi.5.2.10942" @default.
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