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- W2085469249 abstract "Keywords Amelia Limb defects Teratogenic agentsIntroductionAmelia is complete absence of a limb that presents as anisolated defect or with associated malformations. Differentcausal factors like thalidomide, alcohol, amniotic bandsyndrome, maternal diabetes and autosomal recessivemutations have been proposed.We report a case of isolated bilateral upper limb ameliain a woman on antituberculous therapy (ATT) who con-sumed an unidentified drug for sex selection during preconceptional period and first trimester.Case ReportThirty-two year old para 4 was admitted with severeanaemia and puerperal pyrexia following home delivery ofa live born male infant conducted by trained birth attendantin a village 12 days back. Except for absence of both upperlimbs, baby was otherwise healthy with no other congenitaldysmorphic features (Fig. 1). She had healthy living threedaughters, all born by uneventful vaginal deliveries. Patientgave history of having taken two courses of AKT for6 months each, one 3 years back when she was not preg-nant and the other was started from sixth week of gestationduring this pregnancy. The patient received the combina-tion of rifampin, isoniazid and ethambutol. Desirous ofhaving a male baby, she consulted a quack who gave hersome medications in powder form. She took them in themonth preceding the one with missed period and also in thefirst trimester. She did not take any antenatal care and gavebirth to an infant with absent both upper limbs. X-rayexamination of baby’s whole body did not reveal any otherbony anomalies (Fig. 2). Ultrasound examination for rulingout internal organ malformations was reported to be nor-mal. Mother was investigated for puerperal pyrexia. Shereceived four units of packed red cells. At the time ofdischarge, all her biochemical investigations includingblood sugar examination were normal.DiscussionAmelia is an extremely rare congenital anomaly with anincidence of 1.5 per 100,000 live births and 7.9 per 10,000" @default.
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- W2085469249 date "2011-08-01" @default.
- W2085469249 modified "2023-09-23" @default.
- W2085469249 title "Outcome of Gender Bias: Isolated Bilateral Upper Limb Amelia" @default.
- W2085469249 cites W2017539105 @default.
- W2085469249 doi "https://doi.org/10.1007/s13224-011-0050-7" @default.
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