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- W2085471069 abstract "Abstract Some alkane-bis-onium-derivatives display a dual action on acetylcholinesterases: They are reversible inhibitors and delay the irreversible inhibition by DFP. The kinetic analysis of the inhibitory action of the compounds revealed a competitive, a non-competitive or a mixed type of mechanism depending upon the chemical structure. Derivatives with larger substituents act mainly or entirely non-competitively as shown by their α-values. Calculations of the binding energy indicate that all C-atoms of the interionic chain as well as of the substituents at the N-atoms add to the binding via hydrophobic and van der Waal's forces. The non-competitive acting alkane-bis-onium compounds have to be bound to anionic site receptors and adjacent surface areas. An interference with the primary substrate binding does not occur. The acylation, however, of the esteratic site becomes impaired, thus leading to an inhibition of the enzymatic activity as well as a retardation of the phosphorylation by DFP." @default.
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- W2085471069 date "1971-10-01" @default.
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- W2085471069 title "Influence of alkane-bis-onium compounds upon the activity of the AChE and upon its inhibition by DFP" @default.
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- W2085471069 doi "https://doi.org/10.1016/0006-2952(71)90166-3" @default.
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