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- W2085471307 endingPage "425" @default.
- W2085471307 startingPage "414" @default.
- W2085471307 abstract "Studies of dose-escalated external beam radiation therapy (EBRT) and low dose rate brachytherapy (LDR-BT) have shown excellent rates of tumor control and cancer specific survival. Moreover, LDR-BT combined with EBRT (i.e. LDR-BT boost) is hypothesized to improve local control. While phase II trials with LDR-BT boost have produced mature data of outcomes and toxicities, high dose rate (HDR)-BT has been growing in popularity as an alternative boost therapy. Boost from HDR-BT has theoretical advantages over LDR-BT, including improved cancer cell death and better dose distribution from customization of catheter dwell times, locations, and inverse dose optimization. Freedom from biochemical failure rates at five years for low-, intermediate-, high-risk, and locally advanced patients have generally been 85-100%, 80-98%, 59-96%, and 34-85%, respectively. Late Radiation Therapy Oncology Group grade 3-4 toxicities have also been encouraging with <6% of patients experiencing any toxicity. Limitations of current HDR-BT boost studies include reports of only single-institution experiences, and unrefined reports of toxicity or patient quality of life. Comparative effectiveness research will help guide clinicians in selecting the most appropriate treatment option for individual patients based on risk-stratification, expected outcomes, toxicities, quality of life, and cost." @default.
- W2085471307 created "2016-06-24" @default.
- W2085471307 creator A5000741843 @default.
- W2085471307 creator A5042227397 @default.
- W2085471307 creator A5043711745 @default.
- W2085471307 creator A5049018134 @default.
- W2085471307 creator A5051162180 @default.
- W2085471307 creator A5060238737 @default.
- W2085471307 creator A5085025591 @default.
- W2085471307 creator A5085787232 @default.
- W2085471307 date "2014-04-01" @default.
- W2085471307 modified "2023-09-30" @default.
- W2085471307 title "High dose rate brachytherapy boost for prostate cancer: A systematic review" @default.
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