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- W2085474465 abstract "1. Both the direct enzymatic hydrolysis of acetoacetyl-CoA and the 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) pathway occur in mitochondria and cytosol prepared from rat liver. 2. Moreover, an appreciable non-enzymatic hydrolysis of acetoacetyl-CoA occurs. 3. An independant radioactive assay showed, that the HMG-CoA pathway is completely inhibited by iodoacetamide. lodoacetamide may be used to differentiate between the two enzymatic pathways. 4. The four systems for acetoacetate formation (2 pathways in each cell compartment) have about equal activities under our in vitro conditions. 5. Changes in the activities of each of these systems may contribute to alterations of the ketogenic capacity of the liver cell, e.g. during ketosis." @default.
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- W2085474465 date "1977-01-01" @default.
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- W2085474465 title "Conversion of acetoacetyl-coenzyme a into acetoacetate in subcellular liver preparations: Differentiation between the pathways of acetoacetate formation and their localization in the rat liver cell" @default.
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- W2085474465 doi "https://doi.org/10.1016/0020-711x(77)90153-7" @default.
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