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• W2085476772 abstract "Absence of antinatriferic and natriuretic activity in ultrafiltrates (mol wt less than 50,000) and dialysates from volume-expanded dogs. Experiments have been carried out to find out if the antinatriferic and natriuretic activity present in the blood of volume-expanded animals is dialyzable or ultrafilterable. Ultrafiltrates of plasma obtained in vitro , or in vivo , with a 10,000mol wt cutoff filter, from saline-loaded dogs produced no consistent effect on the short circuit current of toad bladder or frog skin. Extracts of dialysates obtained from large volumes of plasma from blood of volume-expanded dogs, and extracts of ultrafiltrates obtained from the plasma of saline-loaded dogs, using 10,000 and 50,000mol wt cut-off filters, did not produce a natriuresis in water-loaded rats. It is concluded that the antinatriferic and natriuretic activity which is present in the blood of volume-expanded animals is not dialyzable or ultrafilterable under the conditions described. Absence d'activite antinatriferrique et natriuretique dans les ultrafiltrats (PM inferieur a 50,000) et les dialysats de chiens ayant subi une expansion. Ce travail a ete realise afin d'etablir si l'activite antinatriferrique et natriuretique presente dans le sang d'animaux ayant subi une expansion est dialysable ou ultrafiltrable. Des ultrafiltrats de plasma obtenus in vitro ou in vivo avec un filtre dont la limite en PM est de 10,000, a partir de chiens ayant subi une expansion avec du solute sale, ne produisent pas d'effets nets sur le courant de court circuit de la vessie de crapaud ou de la peau de grenouille. Des extraits de dialysats obtenus a partir de volumes importants de plasma separe du sang d'animaux ayant subi une expansion du volume sanguin et des extraits d'ultrafiltrats obtenus a partir du plasma de chiens ayant subi une expansion avec du solute sale et au moyen de filtres a 10,000 et 50,000 de limite en PM, ne produisent pas de natriurese chez les rats charges en eau. Il est conclu que l'activite antinatriferrique et natriuretique qui existe dans le sang des animaux ayant subi une expansion n'est pas dialysable ou ultrafiltrable dans les conditions decrites." @default.
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• W2085476772 date "1974-12-01" @default.
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• W2085476772 title "Absence of antinatriferic and natriuretic activity in plasma ultrafiltrates (mol wt less than 50,000) and dialysates from volume-expanded dogs" @default.
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• W2085476772 doi "https://doi.org/10.1038/ki.1974.124" @default.
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