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• W2085479907 endingPage "e70965" @default.
• W2085479907 startingPage "e70965" @default.
• W2085479907 abstract "Non-muscle myosin II is stimulated by monophosphorylation of its regulatory light chain (MRLC) at Ser19 (1P-MRLC). MRLC diphosphorylation at Thr18/Ser19 (2P-MRLC) further enhances the ATPase activity of myosin II. Phosphorylated MRLCs localize to the contractile ring and regulate cytokinesis as subunits of activated myosin II. Recently, we reported that 2P-MRLC, but not 1P-MRLC, localizes to the midzone independently of myosin II heavy chain during cytokinesis in cultured mammalian cells. However, the mechanism underlying the distinct localization of 1P- and 2P-MRLC during cytokinesis is unknown. Here, we showed that depletion of the Rho signaling proteins MKLP1, MgcRacGAP, or ECT2 inhibited the localization of 1P-MRLC to the contractile ring but not the localization of 2P-MRLC to the midzone. In contrast, depleting or inhibiting a midzone-localizing kinase, Aurora B, perturbed the localization of 2P-MRLC to the midzone but not the localization of 1P-MRLC to the contractile ring. We did not observe any change in the localization of phosphorylated MRLC in myosin light-chain kinase (MLCK)-inhibited cells. Furrow regression was observed in Aurora B- and 2P-MRLC-inhibited cells but not in 1P-MRLC-perturbed dividing cells. Furthermore, Aurora B bound to 2P-MRLC in vitro and in vivo. These results suggest that Aurora B, but not Rho/MLCK signaling, is essential for the localization of 2P-MRLC to the midzone in dividing HeLa cells." @default.
• W2085479907 created "2016-06-24" @default.
• W2085479907 creator A5048870494 @default.
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• W2085479907 creator A5072633335 @default.
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• W2085479907 date "2013-08-07" @default.
• W2085479907 modified "2023-10-11" @default.
• W2085479907 title "Aurora B but Not Rho/MLCK Signaling Is Required for Localization of Diphosphorylated Myosin II Regulatory Light Chain to the Midzone in Cytokinesis" @default.
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• W2085479907 doi "https://doi.org/10.1371/journal.pone.0070965" @default.
• W2085479907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3737224" @default.
• W2085479907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23951055" @default.
• W2085479907 hasPublicationYear "2013" @default.
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