FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085488110> ?p ?o ?g. }

• W2085488110 endingPage "72" @default.
• W2085488110 startingPage "65" @default.
• W2085488110 abstract "Following emergence of the tumor stem cell theory, the increasing number of related studies demonstrates the theory's growing importance in cancer research and its potential for clinical applications. Few studies have addressed the in vitro or in vivo properties of glioma stem cells from a Han Chinese population. In the present study, surgically obtained glioblastoma tissue was classified into two subtypes, CD133(+) and CD133(-). The hierarchy, invasiveness, growth tolerance under low nutrient conditions and colony forming abilities of the tissue samples were analyzed. Additionally, the characteristics of tumor cells transplanted subcutaneously or re-transplanted into nude mice were observed. The results demonstrated that CD133(+) glioblastoma cells derived from Han Chinese glioma specimens were more prone to primitive cell differentiation and more invasive than CD133(-) glioblastoma cells, leading to increased tumor malignancy compared with CD133(-) cells. The tumor formation rates of CD133(+) and CD133(-) cells in mice were 26/30 and 2/30, respectively. A comparison of tumor subtypes demonstrated that CD133(+) glioblastoma cells had a lower incidence of cell apoptosis in the tumor tissue and higher protein expression levels of Oct4, Sox2, PCNA, EGFR, Ang2, MMP2 and MMP9 compared with CD133(-) cells. Flow cytometry revealed that in the CD133(+) and CD133(-) glioblastoma cell-induced tumors, the percentage of CD133(+) cells was 2.47±0.67 and 0.44±0.14%, respectively. The tumor formation rates following the re-transplantation of CD133(+) or CD133(-) tumors into nude mice were 10/10 and 4/10, respectively. These findings suggest that the CD133(+) glioblastoma cell subpopulation has a stronger malignant cell phenotype than the CD133(-) subpopulation and that its recurrence rate is increased compared with the primitive tumorigenic rate following in vivo transplantation." @default.
• W2085488110 created "2016-06-24" @default.
• W2085488110 creator A5016031563 @default.
• W2085488110 creator A5019541507 @default.
• W2085488110 creator A5021332651 @default.
• W2085488110 creator A5021989628 @default.
• W2085488110 creator A5036339709 @default.
• W2085488110 creator A5056365908 @default.
• W2085488110 creator A5074896161 @default.
• W2085488110 creator A5084391372 @default.
• W2085488110 date "2012-10-15" @default.
• W2085488110 modified "2023-09-27" @default.
• W2085488110 title "Malignant behaviorial characteristics of CD133+/− glioblastoma cells from a Northern Chinese population" @default.
• W2085488110 cites W1966461436 @default.
• W2085488110 cites W1978597908 @default.
• W2085488110 cites W1983119913 @default.
• W2085488110 cites W1984926967 @default.
• W2085488110 cites W1999356404 @default.
• W2085488110 cites W2013718088 @default.
• W2085488110 cites W2013792040 @default.
• W2085488110 cites W2041532272 @default.
• W2085488110 cites W2047287811 @default.
• W2085488110 cites W2051883611 @default.
• W2085488110 cites W2053343244 @default.
• W2085488110 cites W2063767408 @default.
• W2085488110 cites W2068915942 @default.
• W2085488110 cites W2071584884 @default.
• W2085488110 cites W2078480329 @default.
• W2085488110 cites W2082396938 @default.
• W2085488110 cites W2089531592 @default.
• W2085488110 cites W2108973415 @default.
• W2085488110 cites W2115496571 @default.
• W2085488110 cites W2115577718 @default.
• W2085488110 cites W2134556564 @default.
• W2085488110 cites W2143098252 @default.
• W2085488110 cites W2163995184 @default.
• W2085488110 cites W2167650288 @default.
• W2085488110 cites W2333699031 @default.
• W2085488110 cites W23584388 @default.
• W2085488110 cites W2409926335 @default.
• W2085488110 cites W2413541910 @default.
• W2085488110 cites W79632716 @default.
• W2085488110 doi "https://doi.org/10.3892/etm.2012.747" @default.
• W2085488110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3524257" @default.
• W2085488110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23251243" @default.
• W2085488110 hasPublicationYear "2012" @default.
• W2085488110 type Work @default.
• W2085488110 sameAs 2085488110 @default.
• W2085488110 citedByCount "4" @default.
• W2085488110 countsByYear W20854881102014 @default.
• W2085488110 countsByYear W20854881102016 @default.
• W2085488110 countsByYear W20854881102020 @default.
• W2085488110 crossrefType "journal-article" @default.
• W2085488110 hasAuthorship W2085488110A5016031563 @default.
• W2085488110 hasAuthorship W2085488110A5019541507 @default.
• W2085488110 hasAuthorship W2085488110A5021332651 @default.
• W2085488110 hasAuthorship W2085488110A5021989628 @default.
• W2085488110 hasAuthorship W2085488110A5036339709 @default.
• W2085488110 hasAuthorship W2085488110A5056365908 @default.
• W2085488110 hasAuthorship W2085488110A5074896161 @default.
• W2085488110 hasAuthorship W2085488110A5084391372 @default.
• W2085488110 hasBestOaLocation W20854881101 @default.
• W2085488110 hasConcept C104317684 @default.
• W2085488110 hasConcept C121608353 @default.
• W2085488110 hasConcept C126322002 @default.
• W2085488110 hasConcept C136302470 @default.
• W2085488110 hasConcept C142724271 @default.
• W2085488110 hasConcept C145103041 @default.
• W2085488110 hasConcept C1491633281 @default.
• W2085488110 hasConcept C203014093 @default.
• W2085488110 hasConcept C2777933648 @default.
• W2085488110 hasConcept C2778227246 @default.
• W2085488110 hasConcept C2778287671 @default.
• W2085488110 hasConcept C28328180 @default.
• W2085488110 hasConcept C2908647359 @default.
• W2085488110 hasConcept C2911091166 @default.
• W2085488110 hasConcept C29537977 @default.
• W2085488110 hasConcept C502942594 @default.
• W2085488110 hasConcept C54355233 @default.
• W2085488110 hasConcept C553184892 @default.
• W2085488110 hasConcept C55427017 @default.
• W2085488110 hasConcept C55493867 @default.
• W2085488110 hasConcept C555283112 @default.
• W2085488110 hasConcept C71924100 @default.
• W2085488110 hasConcept C86803240 @default.
• W2085488110 hasConcept C95444343 @default.
• W2085488110 hasConcept C99454951 @default.
• W2085488110 hasConceptScore W2085488110C104317684 @default.
• W2085488110 hasConceptScore W2085488110C121608353 @default.
• W2085488110 hasConceptScore W2085488110C126322002 @default.
• W2085488110 hasConceptScore W2085488110C136302470 @default.
• W2085488110 hasConceptScore W2085488110C142724271 @default.
• W2085488110 hasConceptScore W2085488110C145103041 @default.
• W2085488110 hasConceptScore W2085488110C1491633281 @default.
• W2085488110 hasConceptScore W2085488110C203014093 @default.
• W2085488110 hasConceptScore W2085488110C2777933648 @default.
• W2085488110 hasConceptScore W2085488110C2778227246 @default.
• W2085488110 hasConceptScore W2085488110C2778287671 @default.

• next