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• W2085493064 abstract "Clostridium botulinum type A hemagglutinin‐positive progenitor toxin consists of three distinct components: neurotoxin (NTX), hemagglutinin (HA), and non‐toxic non‐HA (NTNH). The HA consists of four subcomponents designated HA1, 2, 3a and 3b. By employing purified toxin and GST‐fusion proteins of each HA subcomponent, we found that the HA‐positive progenitor toxin, GST‐HA1 and GST‐HA3b bind to human erythrocytes and microvilli of guinea pig upper small intestinal sections. The HA‐positive progenitor toxin and GST‐HA1 bind via galactose moieties, GST‐HA3b binds via sialic acid moieties. GST‐2 and GST‐3a showed no detectable binding." @default.
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• W2085493064 date "2000-02-07" @default.
• W2085493064 modified "2023-10-15" @default.
• W2085493064 title "Identification and characterization of functional subunits of <i>Clostridium botulinum</i> type A progenitor toxin involved in binding to intestinal microvilli and erythrocytes" @default.
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• W2085493064 doi "https://doi.org/10.1016/s0014-5793(00)01147-9" @default.
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