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- W2085493957 abstract "Abstract In many chronic diseases, therapy aims to prevent or reduce the frequency of episodes of a disease manifestation, for example cardiac ischaemic episodes or epileptic seizures. Entry criteria for clinical trials typically include a minimum number of episodes within a baseline period, and regression to the mean should be anticipated. The distribution of the number of episodes at follow‐up, the statistical power for treatment comparisons, and the difficulty of recruitment will depend on the entry criterion chosen. A gamma‐Poisson mixture model is employed to describe the regression to the mean when the entry criterion and outcome measure are counts of discrete events. Sample size formulae which take account of the entry criterion are derived for comparison of mean number of events at follow‐up and the proportion of patients with zero events at follow‐up. Application of these formulae to screening data from the Aymptomatic Cardiac Ischemia Pilot (ACIP) Study is presented as an example." @default.
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- W2085493957 date "1994-04-30" @default.
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- W2085493957 title "Sample size calculation for clinical trials in which entry criteria and outcomes are counts of events" @default.
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- W2085493957 doi "https://doi.org/10.1002/sim.4780130806" @default.
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