Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085494480> ?p ?o ?g. }
- W2085494480 endingPage "553" @default.
- W2085494480 startingPage "546" @default.
- W2085494480 abstract "Nonesterified fatty acids change the expression and properties of the extracellular matrix proteoglycans of arterial and hepatic cells. We review how this may contribute to arterial disease in insulin resistance and type 2 diabetes.Elevated nonesterified fatty acids characterize the dyslipidemia of insulin resistance and type 2 diabetes. In hepatocytes high levels of fatty acids cause changes in proteoglycans leading to a matrix with decreased affinity for VLDL remnants. Furthermore, liver proteoglycans from insulin resistant hyperlipidemic Zucker rats showed alterations also associated with decreased remnant affinity. In arterial smooth muscle cells overexposure to fatty acids augmented expression of matrix proteoglycans for which LDL showed increased affinity. Fatty acids appeared to compromise insulin signaling by protein kinase C activation. The observed fatty acid-induced changes in matrix proteoglycans in liver and arteries can be an important component of the atherogenicity of the dyslipidemia of insulin resistance and type 2 diabetes.Overexposure to fatty acids can contribute to generate a remnant-rich dyslipidemia and to precondition the arterial intima for lipoprotein deposition via changes in expression of matrix proteoglycans. Normalizing fatty acid should be a key target in treatment of the atherogenic dyslipidemia of insulin resistance." @default.
- W2085494480 created "2016-06-24" @default.
- W2085494480 creator A5035038616 @default.
- W2085494480 creator A5058639659 @default.
- W2085494480 creator A5081743142 @default.
- W2085494480 date "2007-10-01" @default.
- W2085494480 modified "2023-09-29" @default.
- W2085494480 title "Fatty acid-induced atherogenic changes in extracellular matrix proteoglycans" @default.
- W2085494480 cites W13558489 @default.
- W2085494480 cites W1556646709 @default.
- W2085494480 cites W1571028605 @default.
- W2085494480 cites W181929250 @default.
- W2085494480 cites W1853133898 @default.
- W2085494480 cites W191405060 @default.
- W2085494480 cites W1950519844 @default.
- W2085494480 cites W1968171440 @default.
- W2085494480 cites W1968659767 @default.
- W2085494480 cites W1973844241 @default.
- W2085494480 cites W1980560570 @default.
- W2085494480 cites W1985962986 @default.
- W2085494480 cites W1993008296 @default.
- W2085494480 cites W1998938358 @default.
- W2085494480 cites W2002693447 @default.
- W2085494480 cites W2008658973 @default.
- W2085494480 cites W2018445977 @default.
- W2085494480 cites W2020659754 @default.
- W2085494480 cites W2023970722 @default.
- W2085494480 cites W2027545409 @default.
- W2085494480 cites W2028872016 @default.
- W2085494480 cites W2035280687 @default.
- W2085494480 cites W2041334177 @default.
- W2085494480 cites W2042383924 @default.
- W2085494480 cites W2043106623 @default.
- W2085494480 cites W2047465218 @default.
- W2085494480 cites W2049023621 @default.
- W2085494480 cites W2054072453 @default.
- W2085494480 cites W2056908901 @default.
- W2085494480 cites W2071355842 @default.
- W2085494480 cites W2073616030 @default.
- W2085494480 cites W2084468357 @default.
- W2085494480 cites W2084544719 @default.
- W2085494480 cites W2090275544 @default.
- W2085494480 cites W2094051977 @default.
- W2085494480 cites W2105046037 @default.
- W2085494480 cites W2109820048 @default.
- W2085494480 cites W2112327050 @default.
- W2085494480 cites W2112760692 @default.
- W2085494480 cites W2114416343 @default.
- W2085494480 cites W2115268091 @default.
- W2085494480 cites W2115480613 @default.
- W2085494480 cites W2119455124 @default.
- W2085494480 cites W2123254143 @default.
- W2085494480 cites W2126364995 @default.
- W2085494480 cites W2129028207 @default.
- W2085494480 cites W2134176648 @default.
- W2085494480 cites W2135859412 @default.
- W2085494480 cites W2135895956 @default.
- W2085494480 cites W2137570167 @default.
- W2085494480 cites W2138063219 @default.
- W2085494480 cites W2142335737 @default.
- W2085494480 cites W2142912243 @default.
- W2085494480 cites W2146175913 @default.
- W2085494480 cites W2152188478 @default.
- W2085494480 cites W2152527784 @default.
- W2085494480 cites W2152745230 @default.
- W2085494480 cites W2154159535 @default.
- W2085494480 cites W2157070951 @default.
- W2085494480 cites W2157280645 @default.
- W2085494480 cites W2157693395 @default.
- W2085494480 cites W2167935502 @default.
- W2085494480 cites W2169151495 @default.
- W2085494480 cites W238671320 @default.
- W2085494480 cites W2422651944 @default.
- W2085494480 doi "https://doi.org/10.1097/mol.0b013e3282ef534f" @default.
- W2085494480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17885426" @default.
- W2085494480 hasPublicationYear "2007" @default.
- W2085494480 type Work @default.
- W2085494480 sameAs 2085494480 @default.
- W2085494480 citedByCount "23" @default.
- W2085494480 countsByYear W20854944802012 @default.
- W2085494480 countsByYear W20854944802013 @default.
- W2085494480 countsByYear W20854944802014 @default.
- W2085494480 countsByYear W20854944802016 @default.
- W2085494480 countsByYear W20854944802018 @default.
- W2085494480 countsByYear W20854944802019 @default.
- W2085494480 countsByYear W20854944802020 @default.
- W2085494480 countsByYear W20854944802023 @default.
- W2085494480 crossrefType "journal-article" @default.
- W2085494480 hasAuthorship W2085494480A5035038616 @default.
- W2085494480 hasAuthorship W2085494480A5058639659 @default.
- W2085494480 hasAuthorship W2085494480A5081743142 @default.
- W2085494480 hasConcept C126322002 @default.
- W2085494480 hasConcept C134018914 @default.
- W2085494480 hasConcept C185592680 @default.
- W2085494480 hasConcept C189165786 @default.
- W2085494480 hasConcept C2777180221 @default.
- W2085494480 hasConcept C2777391703 @default.
- W2085494480 hasConcept C2778096610 @default.