Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085497945> ?p ?o ?g. }
- W2085497945 endingPage "28" @default.
- W2085497945 startingPage "19" @default.
- W2085497945 abstract "SUMMARY Infection with Trypanosoma cruzi causes a profound suppression of T cell responsiveness to polyclonal or antigenic stimuli. In this study, we quantified expression of the negative T cell regulatory molecule CTLA‐4 in T. cruzi infected mice and analysed its influence on the immune suppression. Levels of splenic CTLA‐4 expression were highest around day 10 after infection, reaching 5% in resistant B6D2F1 mice, but exceeding 10% of CD4 + T cells in C57BL/6 mice that were susceptible to mortal disease. The proliferative response of explanted splenocytes to CD3‐mediated stimulation was strongly suppressed in both the susceptible and the resistant strains. Blockade of CTLA‐4 in vitro with a monoclonal antibody affected neither proliferative response nor cytokine production (IFN‐γ, IL‐4 and IL‐2) by splenic T cells from infected C57BL/6 mice. Treatment of mice with anti‐CTLA‐4 antibody on the day of infection decreased IFN‐γ production and reduced mortality by about 50%. We conclude that high CTLA‐4 expression is a hallmark of severe disease in murine T. cruzi infection, and that CTLA‐4 has a regulative influence at the early stages during priming of the immune reaction to the parasite, augmenting a strong Th1‐biased response." @default.
- W2085497945 created "2016-06-24" @default.
- W2085497945 creator A5011269591 @default.
- W2085497945 creator A5019214841 @default.
- W2085497945 creator A5062606038 @default.
- W2085497945 creator A5080923312 @default.
- W2085497945 creator A5081073059 @default.
- W2085497945 date "2004-01-01" @default.
- W2085497945 modified "2023-10-12" @default.
- W2085497945 title "CTLA-4 regulates the murine immune response to Trypanosoma cruzi infection" @default.
- W2085497945 cites W1489445152 @default.
- W2085497945 cites W1491819291 @default.
- W2085497945 cites W1559562302 @default.
- W2085497945 cites W1569612497 @default.
- W2085497945 cites W1579490814 @default.
- W2085497945 cites W1619437296 @default.
- W2085497945 cites W1865580510 @default.
- W2085497945 cites W1937657209 @default.
- W2085497945 cites W1967475931 @default.
- W2085497945 cites W1970282643 @default.
- W2085497945 cites W1982125823 @default.
- W2085497945 cites W1993940422 @default.
- W2085497945 cites W2010542727 @default.
- W2085497945 cites W2015085911 @default.
- W2085497945 cites W2016586610 @default.
- W2085497945 cites W2019098573 @default.
- W2085497945 cites W2019215384 @default.
- W2085497945 cites W2024140769 @default.
- W2085497945 cites W2029865350 @default.
- W2085497945 cites W2031904675 @default.
- W2085497945 cites W2039040160 @default.
- W2085497945 cites W2039191904 @default.
- W2085497945 cites W2041086556 @default.
- W2085497945 cites W2049537946 @default.
- W2085497945 cites W2062056147 @default.
- W2085497945 cites W2066535150 @default.
- W2085497945 cites W2070606570 @default.
- W2085497945 cites W2071483270 @default.
- W2085497945 cites W2072652751 @default.
- W2085497945 cites W2074060262 @default.
- W2085497945 cites W2074765192 @default.
- W2085497945 cites W2076067786 @default.
- W2085497945 cites W2079203596 @default.
- W2085497945 cites W2085592001 @default.
- W2085497945 cites W2094366129 @default.
- W2085497945 cites W2106517085 @default.
- W2085497945 cites W2109737479 @default.
- W2085497945 cites W2111154515 @default.
- W2085497945 cites W2111517025 @default.
- W2085497945 cites W2114837109 @default.
- W2085497945 cites W2116169737 @default.
- W2085497945 cites W2124557384 @default.
- W2085497945 cites W2130026861 @default.
- W2085497945 cites W2134638467 @default.
- W2085497945 cites W2140460887 @default.
- W2085497945 cites W2143281092 @default.
- W2085497945 cites W2153664834 @default.
- W2085497945 cites W2157688402 @default.
- W2085497945 cites W2162466652 @default.
- W2085497945 cites W2171131376 @default.
- W2085497945 cites W2247798071 @default.
- W2085497945 cites W46675784 @default.
- W2085497945 doi "https://doi.org/10.1111/j.0141-9838.2004.00679.x" @default.
- W2085497945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15198642" @default.
- W2085497945 hasPublicationYear "2004" @default.
- W2085497945 type Work @default.
- W2085497945 sameAs 2085497945 @default.
- W2085497945 citedByCount "17" @default.
- W2085497945 countsByYear W20854979452012 @default.
- W2085497945 countsByYear W20854979452014 @default.
- W2085497945 countsByYear W20854979452015 @default.
- W2085497945 countsByYear W20854979452017 @default.
- W2085497945 countsByYear W20854979452019 @default.
- W2085497945 countsByYear W20854979452020 @default.
- W2085497945 crossrefType "journal-article" @default.
- W2085497945 hasAuthorship W2085497945A5011269591 @default.
- W2085497945 hasAuthorship W2085497945A5019214841 @default.
- W2085497945 hasAuthorship W2085497945A5062606038 @default.
- W2085497945 hasAuthorship W2085497945A5080923312 @default.
- W2085497945 hasAuthorship W2085497945A5081073059 @default.
- W2085497945 hasConcept C100701293 @default.
- W2085497945 hasConcept C112418997 @default.
- W2085497945 hasConcept C136764020 @default.
- W2085497945 hasConcept C147483822 @default.
- W2085497945 hasConcept C159654299 @default.
- W2085497945 hasConcept C189976730 @default.
- W2085497945 hasConcept C203014093 @default.
- W2085497945 hasConcept C21705690 @default.
- W2085497945 hasConcept C2776090121 @default.
- W2085497945 hasConcept C2777625466 @default.
- W2085497945 hasConcept C2778690821 @default.
- W2085497945 hasConcept C2780841837 @default.
- W2085497945 hasConcept C41008148 @default.
- W2085497945 hasConcept C542903549 @default.
- W2085497945 hasConcept C59822182 @default.
- W2085497945 hasConcept C71928629 @default.
- W2085497945 hasConcept C81444415 @default.
- W2085497945 hasConcept C86803240 @default.