Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085536648> ?p ?o ?g. }
- W2085536648 endingPage "27" @default.
- W2085536648 startingPage "18" @default.
- W2085536648 abstract "The concept of using immunotherapy to treat melanoma has existed for decades. The rationale comes from the knowledge that many patients with melanoma have endogenous immune responses against their tumor cells and clinically meaningful tumor regression can be achieved in a minority of patients using cytokines such as interleukin-2 and adoptive cellular therapy. In the last 5 years there has been a revolution in the clinical management of melanoma in large measure based on the development of antibodies that influence T cell regulatory pathways by overcoming checkpoint inhibition and providing co-stimulation, either of which results in significantly more effective immune-mediated tumor destruction. This review will describe the pre-clinical and clinical application of antagonistic antibodies targeting the T-cell checkpoints cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed death 1 (PD-1), and agonistic antibodies targeting the costimulatory pathways OX40 and 4-1BB. Recent progress and opportunities for future investigation of combination antibody therapy will be described." @default.
- W2085536648 created "2016-06-24" @default.
- W2085536648 creator A5025100380 @default.
- W2085536648 creator A5029588412 @default.
- W2085536648 date "2015-10-01" @default.
- W2085536648 modified "2023-09-27" @default.
- W2085536648 title "Clinical deployment of antibodies for treatment of melanoma" @default.
- W2085536648 cites W1602037964 @default.
- W2085536648 cites W1766682057 @default.
- W2085536648 cites W1967512987 @default.
- W2085536648 cites W1971364291 @default.
- W2085536648 cites W1974428835 @default.
- W2085536648 cites W1976187277 @default.
- W2085536648 cites W1980137951 @default.
- W2085536648 cites W1990675339 @default.
- W2085536648 cites W2010121426 @default.
- W2085536648 cites W2016789384 @default.
- W2085536648 cites W2021165507 @default.
- W2085536648 cites W2027542837 @default.
- W2085536648 cites W2038324863 @default.
- W2085536648 cites W2038388329 @default.
- W2085536648 cites W2055901890 @default.
- W2085536648 cites W2063264144 @default.
- W2085536648 cites W2064431192 @default.
- W2085536648 cites W2082930742 @default.
- W2085536648 cites W2093541328 @default.
- W2085536648 cites W2094366129 @default.
- W2085536648 cites W2096387850 @default.
- W2085536648 cites W2097855813 @default.
- W2085536648 cites W2097995306 @default.
- W2085536648 cites W2099491780 @default.
- W2085536648 cites W2101581360 @default.
- W2085536648 cites W2101653483 @default.
- W2085536648 cites W2102143045 @default.
- W2085536648 cites W2102862705 @default.
- W2085536648 cites W2103675014 @default.
- W2085536648 cites W2103767560 @default.
- W2085536648 cites W2104885590 @default.
- W2085536648 cites W2105499277 @default.
- W2085536648 cites W2107009614 @default.
- W2085536648 cites W2108789863 @default.
- W2085536648 cites W2108933323 @default.
- W2085536648 cites W2109485845 @default.
- W2085536648 cites W2109653150 @default.
- W2085536648 cites W2112601576 @default.
- W2085536648 cites W2112887207 @default.
- W2085536648 cites W2114903025 @default.
- W2085536648 cites W2118546263 @default.
- W2085536648 cites W2119198740 @default.
- W2085536648 cites W2121080857 @default.
- W2085536648 cites W2121545342 @default.
- W2085536648 cites W2123363005 @default.
- W2085536648 cites W2124427232 @default.
- W2085536648 cites W2128035403 @default.
- W2085536648 cites W2130826590 @default.
- W2085536648 cites W2131192618 @default.
- W2085536648 cites W2135707184 @default.
- W2085536648 cites W2136746908 @default.
- W2085536648 cites W2138229799 @default.
- W2085536648 cites W2142564546 @default.
- W2085536648 cites W2143163879 @default.
- W2085536648 cites W2143467222 @default.
- W2085536648 cites W2147621820 @default.
- W2085536648 cites W2152980179 @default.
- W2085536648 cites W2156253561 @default.
- W2085536648 cites W2156261087 @default.
- W2085536648 cites W2160834915 @default.
- W2085536648 cites W2161367133 @default.
- W2085536648 cites W2164355106 @default.
- W2085536648 cites W2164433065 @default.
- W2085536648 cites W2164842455 @default.
- W2085536648 cites W2166626276 @default.
- W2085536648 cites W2166667372 @default.
- W2085536648 cites W2168839178 @default.
- W2085536648 cites W2264636885 @default.
- W2085536648 cites W2318605753 @default.
- W2085536648 cites W2404196663 @default.
- W2085536648 cites W4205811845 @default.
- W2085536648 doi "https://doi.org/10.1016/j.molimm.2015.01.025" @default.
- W2085536648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25746916" @default.
- W2085536648 hasPublicationYear "2015" @default.
- W2085536648 type Work @default.
- W2085536648 sameAs 2085536648 @default.
- W2085536648 citedByCount "10" @default.
- W2085536648 countsByYear W20855366482015 @default.
- W2085536648 countsByYear W20855366482016 @default.
- W2085536648 countsByYear W20855366482017 @default.
- W2085536648 crossrefType "journal-article" @default.
- W2085536648 hasAuthorship W2085536648A5025100380 @default.
- W2085536648 hasAuthorship W2085536648A5029588412 @default.
- W2085536648 hasConcept C147483822 @default.
- W2085536648 hasConcept C154317977 @default.
- W2085536648 hasConcept C159654299 @default.
- W2085536648 hasConcept C202751555 @default.
- W2085536648 hasConcept C203014093 @default.
- W2085536648 hasConcept C2777658100 @default.
- W2085536648 hasConcept C2777701055 @default.
- W2085536648 hasConcept C2780674031 @default.