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- W2085543463 abstract "Abstract Introduction: In this study of spastic hemiparesis we evaluated cocontraction during sustained agonist/antagonist efforts, before and after botulinum toxin (BoNT) injection in 1 agonist. Methods: Nineteen hemiparetic subjects performed maximal isometric elbow flexion/extension efforts with the elbow at 100° (extensors stretched). Using flexor and extensor surface electromyography we calculated agonist recruitment/cocontraction indices from 500‐ms peak voluntary agonist recruitment, before and 1 month after onabotulinumtoxinA injection (160 U) into biceps brachii. Results: Before injection, agonist recruitment and cocontraction indices were higher in extensors than flexors [0.74 ± 0.15 vs. 0.59 ± 0.10 ( P < 0.01) and 0.43 ± 0.25 vs. 0.25 ± 0.13 ( P < 0.05), respectively]. Biceps injection decreased extensor cocontraction index (−35%, P < 0.05) while increasing flexor agonist recruitment and cocontraction indices. Conclusions: In spastic hemiparesis, stretch may facilitate agonist recruitment and spastic cocontraction. In the non‐injected antagonist, cocontraction may be reduced by enhanced reciprocal inhibition from a more relaxed, and therefore stretched, agonist, or through decreased recurrent inhibition from the injected muscle. Muscle Nerve, 2012" @default.
- W2085543463 created "2016-06-24" @default.
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- W2085543463 date "2012-10-05" @default.
- W2085543463 modified "2023-10-18" @default.
- W2085543463 title "Spastic cocontraction in hemiparesis: Effects of botulinum toxin" @default.
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- W2085543463 doi "https://doi.org/10.1002/mus.23427" @default.
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