FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085543881> ?p ?o ?g. }

• W2085543881 endingPage "e6600" @default.
• W2085543881 startingPage "e6600" @default.
• W2085543881 abstract "Background Inflammation in the early stages of sepsis is governed by the innate immune response. Costimulatory molecules are a receptor/ligand class of molecules capable of regulation of inflammation in innate immunity via macrophage/neutrophil contact. We recently described that CD80/86 ligation is required for maximal macrophage activation and CD80/86−/− mice display reduced mortality and inflammatory cytokine production after cecal ligation and puncture (CLP). However, these data also demonstrate differential regulation of CD80 and CD86 expression in sepsis, suggesting a divergent role for these receptors. Therefore, the goal of this study was to determine the individual contribution of CD80/86 family members in regulating inflammation in sepsis. Methodology/Principal Findings CD80−/− mice had improved survival after CLP when compared to WT or CD86−/− mice. This was associated with preferential attenuation of inflammatory cytokine production in CD80−/− mice. Results were confirmed with pharmacologic blockade, with anti-CD80 mAb rescuing mice when administered before or after CLP. In vitro, activation of macrophages with neutrophil lipid rafts caused selective disassociation of IRAK-M, a negative regulator of NF-κB signaling from CD80; providing a mechanism for preferential regulation of cytokine production by CD80. Finally, in humans, upregulation of CD80 and loss of constitutive CD86 expression on monocytes was associated with higher severity of illness and inflammation confirming the findings in our mouse model. Conclusions In conclusion, our data describe a differential role for CD80 and CD86 in regulation of inflammation in the innate immune response to sepsis. Future therapeutic strategies for blockade of the CD80/86 system in sepsis should focus on direct inhibition of CD80." @default.
• W2085543881 created "2016-06-24" @default.
• W2085543881 creator A5002357141 @default.
• W2085543881 creator A5006434779 @default.
• W2085543881 creator A5006850774 @default.
• W2085543881 creator A5008330886 @default.
• W2085543881 creator A5028798965 @default.
• W2085543881 creator A5039004312 @default.
• W2085543881 creator A5043893590 @default.
• W2085543881 creator A5062983227 @default.
• W2085543881 creator A5071033429 @default.
• W2085543881 creator A5017713085 @default.
• W2085543881 date "2009-08-12" @default.
• W2085543881 modified "2023-10-17" @default.
• W2085543881 title "Differential Role for CD80 and CD86 in the Regulation of the Innate Immune Response in Murine Polymicrobial Sepsis" @default.
• W2085543881 cites W1489480103 @default.
• W2085543881 cites W1494843398 @default.
• W2085543881 cites W1533964517 @default.
• W2085543881 cites W1963975982 @default.
• W2085543881 cites W1965139884 @default.
• W2085543881 cites W1965786965 @default.
• W2085543881 cites W1972364434 @default.
• W2085543881 cites W1977905350 @default.
• W2085543881 cites W1978514350 @default.
• W2085543881 cites W2004107890 @default.
• W2085543881 cites W2037920661 @default.
• W2085543881 cites W2041980736 @default.
• W2085543881 cites W2044073735 @default.
• W2085543881 cites W2049927822 @default.
• W2085543881 cites W2057979643 @default.
• W2085543881 cites W2082729009 @default.
• W2085543881 cites W2083454520 @default.
• W2085543881 cites W2087757222 @default.
• W2085543881 cites W2119524661 @default.
• W2085543881 cites W2123506683 @default.
• W2085543881 cites W2127387126 @default.
• W2085543881 cites W2129846179 @default.
• W2085543881 cites W2131071041 @default.
• W2085543881 cites W2141989396 @default.
• W2085543881 cites W2145577370 @default.
• W2085543881 cites W2154110008 @default.
• W2085543881 cites W2154571798 @default.
• W2085543881 cites W2156511153 @default.
• W2085543881 cites W2768146862 @default.
• W2085543881 cites W4248219898 @default.
• W2085543881 cites W4322387790 @default.
• W2085543881 doi "https://doi.org/10.1371/journal.pone.0006600" @default.
• W2085543881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2719911" @default.
• W2085543881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19672303" @default.
• W2085543881 hasPublicationYear "2009" @default.
• W2085543881 type Work @default.
• W2085543881 sameAs 2085543881 @default.
• W2085543881 citedByCount "96" @default.
• W2085543881 countsByYear W20855438812012 @default.
• W2085543881 countsByYear W20855438812013 @default.
• W2085543881 countsByYear W20855438812014 @default.
• W2085543881 countsByYear W20855438812015 @default.
• W2085543881 countsByYear W20855438812016 @default.
• W2085543881 countsByYear W20855438812017 @default.
• W2085543881 countsByYear W20855438812018 @default.
• W2085543881 countsByYear W20855438812019 @default.
• W2085543881 countsByYear W20855438812020 @default.
• W2085543881 countsByYear W20855438812021 @default.
• W2085543881 countsByYear W20855438812022 @default.
• W2085543881 countsByYear W20855438812023 @default.
• W2085543881 crossrefType "journal-article" @default.
• W2085543881 hasAuthorship W2085543881A5002357141 @default.
• W2085543881 hasAuthorship W2085543881A5006434779 @default.
• W2085543881 hasAuthorship W2085543881A5006850774 @default.
• W2085543881 hasAuthorship W2085543881A5008330886 @default.
• W2085543881 hasAuthorship W2085543881A5017713085 @default.
• W2085543881 hasAuthorship W2085543881A5028798965 @default.
• W2085543881 hasAuthorship W2085543881A5039004312 @default.
• W2085543881 hasAuthorship W2085543881A5043893590 @default.
• W2085543881 hasAuthorship W2085543881A5062983227 @default.
• W2085543881 hasAuthorship W2085543881A5071033429 @default.
• W2085543881 hasBestOaLocation W20855438811 @default.
• W2085543881 hasConcept C136449434 @default.
• W2085543881 hasConcept C154317977 @default.
• W2085543881 hasConcept C202751555 @default.
• W2085543881 hasConcept C203014093 @default.
• W2085543881 hasConcept C2776090121 @default.
• W2085543881 hasConcept C2776914184 @default.
• W2085543881 hasConcept C2778297628 @default.
• W2085543881 hasConcept C2778690821 @default.
• W2085543881 hasConcept C2781101188 @default.
• W2085543881 hasConcept C39347974 @default.
• W2085543881 hasConcept C55493867 @default.
• W2085543881 hasConcept C86803240 @default.
• W2085543881 hasConcept C8891405 @default.
• W2085543881 hasConceptScore W2085543881C136449434 @default.
• W2085543881 hasConceptScore W2085543881C154317977 @default.
• W2085543881 hasConceptScore W2085543881C202751555 @default.
• W2085543881 hasConceptScore W2085543881C203014093 @default.
• W2085543881 hasConceptScore W2085543881C2776090121 @default.
• W2085543881 hasConceptScore W2085543881C2776914184 @default.
• W2085543881 hasConceptScore W2085543881C2778297628 @default.
• W2085543881 hasConceptScore W2085543881C2778690821 @default.

• next