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• W2085546458 endingPage "393" @default.
• W2085546458 startingPage "383" @default.
• W2085546458 abstract "Abstract Secretory phospholipase A 2 group IIA(sPLA 2 IIA) can be produced and secreted by various cell types either constitutionally or as an acute‐phase reactant upon stimulation by proinflammatory cytokines. The enzyme prefers phosphatidylethanolamine and phosphatidylserine as substrates. One important biological function may be the hydrolytic destruction of bacterial membranes. It has been demonstrated, however, that sPLA 2 can also hydrolyse the phospholipid monolayers of high density lipoprotein (HDL) and low density lipoprotein (LDL) in vitro . Secretory phospholipase A 2 ‐modified LDL show increased affinity to glycosaminoglycans and proteoglycans, a tendency to aggregate, and an enhanced ability to deliver cholesterol to cells. Incubation of cultured macrophages with PLA 2 ‐treated LDL and HDL is associated with increased intracellular lipid accumulation, resulting in the formation of foam cells. Elevated sPLA 2 (IIA) activity in blood serum leads to an increased clearance of serum cholesterol. Secretory phospholipase A 2 (IIA) can also be detected in the intima, adventitia and media of the atherosclerotic wall not only in developed lesions but also in very early stages of atherosclerosis. The presence of DNA of Chlamydia pneumoniae , herpes simplex virus, and cytomegalovirus was found to be associated with sPLA 2 (IIA) expression and other signs of local inflammation. Thus, sPLA 2 (IIA) appears to be one important link between the lipid and the inflammation hypothesis of atherosclerosis." @default.
• W2085546458 created "2016-06-24" @default.
• W2085546458 creator A5027940724 @default.
• W2085546458 creator A5047480914 @default.
• W2085546458 creator A5081892688 @default.
• W2085546458 date "2002-06-01" @default.
• W2085546458 modified "2023-10-18" @default.
• W2085546458 title "Biological effects of secretory phospholipase A₂group IIA on lipoproteins and in atherogenesis" @default.
• W2085546458 cites W114248912 @default.
• W2085546458 cites W11606563 @default.
• W2085546458 cites W1495966620 @default.
• W2085546458 cites W1501606466 @default.
• W2085546458 cites W1529376098 @default.
• W2085546458 cites W1533108071 @default.
• W2085546458 cites W1541426877 @default.
• W2085546458 cites W1561795287 @default.
• W2085546458 cites W1568812849 @default.
• W2085546458 cites W1581382592 @default.
• W2085546458 cites W1583215218 @default.
• W2085546458 cites W1585450904 @default.
• W2085546458 cites W1585634514 @default.
• W2085546458 cites W1598614064 @default.
• W2085546458 cites W1641540149 @default.
• W2085546458 cites W1659985814 @default.
• W2085546458 cites W1696959307 @default.
• W2085546458 cites W174150405 @default.
• W2085546458 cites W1751643275 @default.
• W2085546458 cites W1771837556 @default.
• W2085546458 cites W1790333260 @default.
• W2085546458 cites W1805766162 @default.
• W2085546458 cites W1857396158 @default.
• W2085546458 cites W1960586600 @default.
• W2085546458 cites W1966089227 @default.
• W2085546458 cites W1967890561 @default.
• W2085546458 cites W1968567802 @default.
• W2085546458 cites W1969979270 @default.
• W2085546458 cites W1973258392 @default.
• W2085546458 cites W1975770362 @default.
• W2085546458 cites W1976616374 @default.
• W2085546458 cites W1979763498 @default.
• W2085546458 cites W1980355522 @default.
• W2085546458 cites W1981424519 @default.
• W2085546458 cites W1985170971 @default.
• W2085546458 cites W1985454544 @default.
• W2085546458 cites W1986872682 @default.
• W2085546458 cites W1990473810 @default.
• W2085546458 cites W1992405521 @default.
• W2085546458 cites W1993667392 @default.
• W2085546458 cites W1994395273 @default.
• W2085546458 cites W1999709898 @default.
• W2085546458 cites W2000162659 @default.
• W2085546458 cites W2009702652 @default.
• W2085546458 cites W2010797723 @default.
• W2085546458 cites W2011014206 @default.
• W2085546458 cites W2011390446 @default.
• W2085546458 cites W2015871485 @default.
• W2085546458 cites W2015979346 @default.
• W2085546458 cites W2021587541 @default.
• W2085546458 cites W2021594206 @default.
• W2085546458 cites W2024101356 @default.
• W2085546458 cites W2024131238 @default.
• W2085546458 cites W2024945505 @default.
• W2085546458 cites W2025723120 @default.
• W2085546458 cites W2026085322 @default.
• W2085546458 cites W2030202173 @default.
• W2085546458 cites W2031848257 @default.
• W2085546458 cites W2032607839 @default.
• W2085546458 cites W2033834096 @default.
• W2085546458 cites W2035551442 @default.
• W2085546458 cites W2037466306 @default.
• W2085546458 cites W2039802164 @default.
• W2085546458 cites W2040374028 @default.
• W2085546458 cites W2040389967 @default.
• W2085546458 cites W2045147217 @default.
• W2085546458 cites W2046346838 @default.
• W2085546458 cites W2046729716 @default.
• W2085546458 cites W2048081925 @default.
• W2085546458 cites W2050874860 @default.
• W2085546458 cites W2051841044 @default.
• W2085546458 cites W2054906991 @default.
• W2085546458 cites W2056709424 @default.
• W2085546458 cites W2059384713 @default.
• W2085546458 cites W2061159556 @default.
• W2085546458 cites W2067356081 @default.
• W2085546458 cites W2068396845 @default.
• W2085546458 cites W2069253950 @default.
• W2085546458 cites W2072879578 @default.
• W2085546458 cites W2073000116 @default.
• W2085546458 cites W2073190601 @default.
• W2085546458 cites W2077476419 @default.
• W2085546458 cites W2079076761 @default.
• W2085546458 cites W2083851880 @default.
• W2085546458 cites W2084116516 @default.
• W2085546458 cites W2084417274 @default.
• W2085546458 cites W2084564143 @default.
• W2085546458 cites W2085148429 @default.
• W2085546458 cites W2085597192 @default.
• W2085546458 cites W2086152762 @default.

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