FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085547717> ?p ?o ?g. }

• W2085547717 endingPage "1065" @default.
• W2085547717 startingPage "1051" @default.
• W2085547717 abstract "Cyclooxygenase-2 is expressed at low levels in a subset of neurons in CNS and is rapidly induced by a multiplicity of factors including seizure activity. A putative relationship exists between cyclooxygenase-2 induction and glutamatergic neurotransmission. Cyclooxygenase-1 is constitutively expressed in glial cells and has been specifically linked to microglia. In this study we evaluated cyclooxygenase-2 protein immunocytochemically and found markedly enhanced immunostaining primarily in olfactory-limbic regions at 2, 6 and 24 h following kainate-induced status epilepticus. Impressive enhanced cyclooxygenase-2 immunoreactivity was localized in anterior olfactory nucleus, tenia tecta, nucleus of the lateral olfactory tract, piriform cortex, lateral and basolateral amygdala, orbital frontal cortex, nucleus accumbens (shell) and associated areas of ventral striatum, entorhinal cortex, dentate gyrus granule cells and hilar neurons, hippocampal CA subfields and subiculum. Alternate sections were processed for dual immunocytochemical analysis utilizing c-Fos and cyclooxygenase-2 antiserum to examine the possibility that the neuronal induction of cyclooxygenase-2 was associated with seizure activity. Neurons that showed a timeline of cyclooxygenase-2 upregulation were found to possess c-Fos immunopositive nuclei. Additional results from all seizure groups showed cyclooxygenase-1 induction in microglia, which was confirmed by Western blot analysis of hippocampus. Western blot and real-time quantitative RT-PCR analysis showed significant upregulation of cyclooxygenase-2 expression, confirming its induction in neurons. These data indicate that cyclooxygenase-2 induction in a neuronal network can be a useful marker for pathways associated with seizure activity." @default.
• W2085547717 created "2016-06-24" @default.
• W2085547717 creator A5013938996 @default.
• W2085547717 creator A5028213565 @default.
• W2085547717 creator A5038446642 @default.
• W2085547717 creator A5048934790 @default.
• W2085547717 creator A5064574703 @default.
• W2085547717 creator A5083667736 @default.
• W2085547717 creator A5086808677 @default.
• W2085547717 date "2006-01-01" @default.
• W2085547717 modified "2023-10-17" @default.
• W2085547717 title "Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures" @default.
• W2085547717 cites W141203753 @default.
• W2085547717 cites W1480035757 @default.
• W2085547717 cites W1587059515 @default.
• W2085547717 cites W17682570 @default.
• W2085547717 cites W1800831454 @default.
• W2085547717 cites W1827373965 @default.
• W2085547717 cites W19003993 @default.
• W2085547717 cites W1963980380 @default.
• W2085547717 cites W1973426426 @default.
• W2085547717 cites W1977253719 @default.
• W2085547717 cites W1980681889 @default.
• W2085547717 cites W1986025484 @default.
• W2085547717 cites W1986280375 @default.
• W2085547717 cites W1988571549 @default.
• W2085547717 cites W1989904263 @default.
• W2085547717 cites W1993050229 @default.
• W2085547717 cites W1993572533 @default.
• W2085547717 cites W2002605614 @default.
• W2085547717 cites W2003454030 @default.
• W2085547717 cites W2004180367 @default.
• W2085547717 cites W2005303361 @default.
• W2085547717 cites W2005700669 @default.
• W2085547717 cites W2008424322 @default.
• W2085547717 cites W2013926783 @default.
• W2085547717 cites W2015047283 @default.
• W2085547717 cites W2016293448 @default.
• W2085547717 cites W2016760563 @default.
• W2085547717 cites W2017192155 @default.
• W2085547717 cites W2020972983 @default.
• W2085547717 cites W2021729913 @default.
• W2085547717 cites W2022628849 @default.
• W2085547717 cites W2022681040 @default.
• W2085547717 cites W2023588733 @default.
• W2085547717 cites W2024042286 @default.
• W2085547717 cites W2035562497 @default.
• W2085547717 cites W2035862839 @default.
• W2085547717 cites W2042315877 @default.
• W2085547717 cites W2045410193 @default.
• W2085547717 cites W2045686193 @default.
• W2085547717 cites W2049381848 @default.
• W2085547717 cites W2052263727 @default.
• W2085547717 cites W2059223526 @default.
• W2085547717 cites W2059934843 @default.
• W2085547717 cites W2068665404 @default.
• W2085547717 cites W2071792443 @default.
• W2085547717 cites W2081115605 @default.
• W2085547717 cites W2081697928 @default.
• W2085547717 cites W2085251042 @default.
• W2085547717 cites W2086033214 @default.
• W2085547717 cites W2091028315 @default.
• W2085547717 cites W2092700031 @default.
• W2085547717 cites W2097298436 @default.
• W2085547717 cites W2101736298 @default.
• W2085547717 cites W2103089294 @default.
• W2085547717 cites W2110809517 @default.
• W2085547717 cites W2116273500 @default.
• W2085547717 cites W2129457590 @default.
• W2085547717 cites W2133381874 @default.
• W2085547717 cites W2136709687 @default.
• W2085547717 cites W2141186235 @default.
• W2085547717 cites W2146957909 @default.
• W2085547717 cites W2147710510 @default.
• W2085547717 cites W2167023063 @default.
• W2085547717 cites W2404884509 @default.
• W2085547717 doi "https://doi.org/10.1016/j.neuroscience.2006.02.075" @default.
• W2085547717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16677768" @default.
• W2085547717 hasPublicationYear "2006" @default.
• W2085547717 type Work @default.
• W2085547717 sameAs 2085547717 @default.
• W2085547717 citedByCount "17" @default.
• W2085547717 countsByYear W20855477172012 @default.
• W2085547717 countsByYear W20855477172015 @default.
• W2085547717 countsByYear W20855477172018 @default.
• W2085547717 countsByYear W20855477172021 @default.
• W2085547717 countsByYear W20855477172022 @default.
• W2085547717 countsByYear W20855477172023 @default.
• W2085547717 crossrefType "journal-article" @default.
• W2085547717 hasAuthorship W2085547717A5013938996 @default.
• W2085547717 hasAuthorship W2085547717A5028213565 @default.
• W2085547717 hasAuthorship W2085547717A5038446642 @default.
• W2085547717 hasAuthorship W2085547717A5048934790 @default.
• W2085547717 hasAuthorship W2085547717A5064574703 @default.
• W2085547717 hasAuthorship W2085547717A5083667736 @default.
• W2085547717 hasAuthorship W2085547717A5086808677 @default.
• W2085547717 hasConcept C110726550 @default.
• W2085547717 hasConcept C148762608 @default.

• next