Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085557186> ?p ?o ?g. }
- W2085557186 endingPage "356" @default.
- W2085557186 startingPage "348" @default.
- W2085557186 abstract "The basic helix-loop-helix (bHLH) transcription factor TCF4 was confirmed in the combined analysis of several large genome-wide association studies (GWAS) as one of the rare highly replicated significant schizophrenia (SZ) susceptibility genes in large case-control cohorts. Focused genetic association studies showed that TCF4 influences verbal learning and memory, and modulates sensorimotor gating. Mice overexpressing Tcf4 in the forebrain (Tcf4tg) display cognitive deficits in hippocampus-dependent learning tasks and impairment of prepulse inhibition, a well-established endophenotype of SZ. The spectrum of cognitive deficits in SZ subjects, however, is broad and covers attention, working memory, and anticipation. Collectively, these higher order cognitive processes and the recall of remote memories are thought to depend mainly on prefrontal cortical networks. To further investigate cognitive disturbances in Tcf4tg mice, we employed the trace fear conditioning paradigm that requires attention and critically depends on the anterior cingulate cortex (ACC). We show that Tcf4tg mice display deficits in recent and remote trace fear memory and are impaired at anticipating aversive stimuli. We also assessed mRNA expression of the neuronal activity-regulated gene Fos in the ACC and hippocampus. Upon trace conditioning, Fos expression is reduced in Tcf4tg mice as compared to controls, which parallels cognitive impairments in this learning paradigm. Collectively, these data indicate that the reduced cognitive performance in Tcf4tg mice includes deficits at the level of attention and behavioral anticipation." @default.
- W2085557186 created "2016-06-24" @default.
- W2085557186 creator A5021393291 @default.
- W2085557186 creator A5035454289 @default.
- W2085557186 date "2013-01-01" @default.
- W2085557186 modified "2023-10-17" @default.
- W2085557186 title "Deficits in trace fear memory in a mouse model of the schizophrenia risk gene TCF4" @default.
- W2085557186 cites W1493874440 @default.
- W2085557186 cites W1523637894 @default.
- W2085557186 cites W1562926869 @default.
- W2085557186 cites W1581458838 @default.
- W2085557186 cites W1592661589 @default.
- W2085557186 cites W1694363227 @default.
- W2085557186 cites W1969191015 @default.
- W2085557186 cites W1972401591 @default.
- W2085557186 cites W1974258590 @default.
- W2085557186 cites W1980967004 @default.
- W2085557186 cites W1983374134 @default.
- W2085557186 cites W1986012256 @default.
- W2085557186 cites W1989757714 @default.
- W2085557186 cites W1993616139 @default.
- W2085557186 cites W1994226910 @default.
- W2085557186 cites W1995954315 @default.
- W2085557186 cites W2002932881 @default.
- W2085557186 cites W2003372190 @default.
- W2085557186 cites W2023237396 @default.
- W2085557186 cites W2024758252 @default.
- W2085557186 cites W2027691566 @default.
- W2085557186 cites W2028127185 @default.
- W2085557186 cites W2035993165 @default.
- W2085557186 cites W2043192509 @default.
- W2085557186 cites W2047867886 @default.
- W2085557186 cites W2050704896 @default.
- W2085557186 cites W2053179419 @default.
- W2085557186 cites W2056513283 @default.
- W2085557186 cites W2060801754 @default.
- W2085557186 cites W2060884332 @default.
- W2085557186 cites W2060927124 @default.
- W2085557186 cites W2064930833 @default.
- W2085557186 cites W2066029568 @default.
- W2085557186 cites W2067874260 @default.
- W2085557186 cites W2068775428 @default.
- W2085557186 cites W2069348681 @default.
- W2085557186 cites W2075120830 @default.
- W2085557186 cites W2075269782 @default.
- W2085557186 cites W2089107511 @default.
- W2085557186 cites W2089817334 @default.
- W2085557186 cites W2093335984 @default.
- W2085557186 cites W2095256251 @default.
- W2085557186 cites W2100243927 @default.
- W2085557186 cites W2102481727 @default.
- W2085557186 cites W2102912401 @default.
- W2085557186 cites W2105516121 @default.
- W2085557186 cites W2105606809 @default.
- W2085557186 cites W2107277218 @default.
- W2085557186 cites W2110871941 @default.
- W2085557186 cites W2116680819 @default.
- W2085557186 cites W2119515211 @default.
- W2085557186 cites W2122165239 @default.
- W2085557186 cites W2125823313 @default.
- W2085557186 cites W2126210212 @default.
- W2085557186 cites W2127205775 @default.
- W2085557186 cites W2130928508 @default.
- W2085557186 cites W2131370784 @default.
- W2085557186 cites W2131618009 @default.
- W2085557186 cites W2132853326 @default.
- W2085557186 cites W2135799745 @default.
- W2085557186 cites W2136848562 @default.
- W2085557186 cites W2138110238 @default.
- W2085557186 cites W2138561974 @default.
- W2085557186 cites W2140280664 @default.
- W2085557186 cites W2144116954 @default.
- W2085557186 cites W2152032880 @default.
- W2085557186 cites W2153774613 @default.
- W2085557186 cites W2157468016 @default.
- W2085557186 cites W2161527093 @default.
- W2085557186 cites W2164065724 @default.
- W2085557186 cites W2167248961 @default.
- W2085557186 cites W2168296897 @default.
- W2085557186 cites W2169371126 @default.
- W2085557186 cites W2169869700 @default.
- W2085557186 cites W2171097245 @default.
- W2085557186 cites W2171154298 @default.
- W2085557186 cites W2173389596 @default.
- W2085557186 cites W4232755968 @default.
- W2085557186 cites W2041222660 @default.
- W2085557186 doi "https://doi.org/10.1016/j.bbr.2012.10.001" @default.
- W2085557186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23069005" @default.
- W2085557186 hasPublicationYear "2013" @default.
- W2085557186 type Work @default.
- W2085557186 sameAs 2085557186 @default.
- W2085557186 citedByCount "31" @default.
- W2085557186 countsByYear W20855571862013 @default.
- W2085557186 countsByYear W20855571862014 @default.
- W2085557186 countsByYear W20855571862015 @default.
- W2085557186 countsByYear W20855571862016 @default.
- W2085557186 countsByYear W20855571862017 @default.
- W2085557186 countsByYear W20855571862018 @default.