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- W2085560535 abstract "Despite more than 50 years of effort, the origin of the genetic code remains enigmatic. Among different theories, the stereochemical hypothesis suggests that the code evolved as a consequence of direct interactions between amino acids and appropriate bases. If indeed true, such physicochemical foundation of the mRNA/protein relationship could also potentially lead to novel principles of protein-mRNA interactions in general. Inspired by this promise, we have recently explored the connection between the physicochemical properties of mRNAs and their cognate proteins at the proteome level. Using experimentally and computationally derived measures of solubility of amino acids in aqueous solutions of pyrimidine analogs together with knowledge-based interaction preferences of amino acids for different nucleobases, we have revealed a statistically significant matching between the composition of mRNA coding sequences and the base-binding preferences of their cognate protein sequences. Our findings provide strong support for the stereochemical hypothesis of genetic code’s origin and suggest the possibility of direct complementary interactions between mRNAs and cognate proteins even in present-day cells." @default.
- W2085560535 created "2016-06-24" @default.
- W2085560535 creator A5034668657 @default.
- W2085560535 creator A5083503483 @default.
- W2085560535 creator A5089609962 @default.
- W2085560535 date "2013-08-01" @default.
- W2085560535 modified "2023-10-16" @default.
- W2085560535 title "Proteome-wide analysis reveals clues of complementary interactions between mRNAs and their cognate proteins as the physicochemical foundation of the genetic code" @default.
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- W2085560535 doi "https://doi.org/10.4161/rna.25977" @default.
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