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• W2085563404 abstract "HIGHER PREVALENCE OF CV-RELATED COMORBIDITIES IN US ADULTS WITH STAGE IIIB CKD SUPPORTS A MODIFICATION TO THE EXISTING NKF/KDIGO CLASSIFICATION OF CKD Daniel Wilson, Andreas Kuznik, Jack Mardekian, Lisa Tarasenko Pfizer Inc, New York, NY, USA Some clinicians have recommended revision of the current NKF/KDIGO classification of CKD and establishing Stages IIIa and IIIb CKD because of perceived differences in CV risk profiles in Stage III. CKD is often associated with CV target organ damage and CHD risk equivalents. In this analysis of a nationally representative database, we quantified the prevalence of CVD and CHD risk equivalents in US adults by CKD stage, utilizing the suggested modification of Stage III CKD, in an attempt to determine if such a revision is warranted. Data from NHANES 2001–2008 were stratified by CKD stage; eGFR was calculated using the 4-variable MDRD Study equation. CKD staging used modified NKF criteria: Stage III CKD was subdivided into Stage IIIa (eGFR >45–<60 mL/min/1.73m) and Stage IIIb (eGFR 30– <45 mL/min/1.73m). CVD history was self reported; DM was identified by self report, use of diabetic medications, or fasting glucose ≥126 mg/dL. Of the NHANES participants with valid renal data, 12% had CKD. The prevalence of CV-related comorbidities increased with progressive renal impairment (Table). Prevalence of CVD, CHD and stroke increased markedly between CKD Stage IIIa and IIIb. Prevalence of DM was notably higher in Stage IV versus Stage I CKD. CKD Stage CVD* CHD Stroke DM Normal 5.9% 4.2% 1.9% 7.8% I 10.9% 7.2% 2.8% 33.7% II 24.3% 17.6% 6.5% 30.9% IIIa 25.6% 19.1% 7.9% 20.4% IIIb 48.7% 33.6% 23.5% 33.1% IV 60.1% 42.6% 33.2% 49.1% *Composite of CHD, stroke and CHF Persons with CKD, especially those with advanced renal impairment, have a high prevalence of concomitant CVD. Our analysis supports the proposed revision of the current NKF/KDIGO classification of CKD, as the prevalence of specific CV comorbidities and CHD risk equivalents was substantially higher in Stage IIIb versus IIIa CKD." @default.
• W2085563404 created "2016-06-24" @default.
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• W2085563404 date "2011-04-01" @default.
• W2085563404 modified "2023-09-25" @default.
• W2085563404 title "357 Higher Prevalence of CV-Related Comorbidities in US Adults With Stage IIIB CKD Supports a Modification to the Existing NKF/KDIGO Classification of CKD" @default.
• W2085563404 doi "https://doi.org/10.1053/j.ajkd.2011.02.360" @default.
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