FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085578960> ?p ?o ?g. }

• W2085578960 endingPage "3906" @default.
• W2085578960 startingPage "3901" @default.
• W2085578960 abstract "The purpose of this study was to investigate anti-tumor effects and safety of DH332, a new β-carboline alkaloids derivatives in vitro and in vivo.The effects of DH332 on human (RAMOS RA.1) and mouse (J558) B lymphoma cell lines were detected using a CCK-8 kit (Cell Counting Kit-8), and apoptosis was detected by flow cytometry with PI/annexinV staining. Western blotting was used to detected caspase-3 and caspase-8. Neurotoxic and anti-tumor effects were evaluated in animal experiments.DH332 exerts a lower neurotoxicity compared with harmine. It also possesses strong antitumor effects against two B cell lymphoma cell lines with low IC50s. Moreover, DH332 could inhibit the proliferation and induce the apoptosis of RAMOS RA.1 and J558 cell lines in a dose-dependent manner. Our results suggest that DH332 triggers apoptosis by mainly activating the caspase signaling pathway. In vivo studies of tumor-bearing BALB/c mice showed that DH332 significantly inhibited growth of J558 xenograft tumors.DH332 exerts effective antitumor activity in vitro and in vivo, and has the potential to be a promising drug candidate for lymphoma therapy." @default.
• W2085578960 created "2016-06-24" @default.
• W2085578960 creator A5022408570 @default.
• W2085578960 creator A5050907965 @default.
• W2085578960 creator A5063793551 @default.
• W2085578960 creator A5064144163 @default.
• W2085578960 creator A5075048913 @default.
• W2085578960 creator A5075732221 @default.
• W2085578960 creator A5090366405 @default.
• W2085578960 date "2014-05-15" @default.
• W2085578960 modified "2023-09-27" @default.
• W2085578960 title "DH332, a Synthetic β-Carboline Alkaloid, Inhibits B Cell Lymphoma Growth by Activation of the Caspase Family" @default.
• W2085578960 cites W1965822529 @default.
• W2085578960 cites W1981745546 @default.
• W2085578960 cites W1983969534 @default.
• W2085578960 cites W1985742612 @default.
• W2085578960 cites W1996046977 @default.
• W2085578960 cites W2006122419 @default.
• W2085578960 cites W2019271000 @default.
• W2085578960 cites W2038729399 @default.
• W2085578960 cites W2042790201 @default.
• W2085578960 cites W2045857361 @default.
• W2085578960 cites W2049658505 @default.
• W2085578960 cites W2058072416 @default.
• W2085578960 cites W2074478733 @default.
• W2085578960 cites W2089599210 @default.
• W2085578960 cites W2137598892 @default.
• W2085578960 cites W2140805243 @default.
• W2085578960 doi "https://doi.org/10.7314/apjcp.2014.15.9.3901" @default.
• W2085578960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24935571" @default.
• W2085578960 hasPublicationYear "2014" @default.
• W2085578960 type Work @default.
• W2085578960 sameAs 2085578960 @default.
• W2085578960 citedByCount "2" @default.
• W2085578960 countsByYear W20855789602019 @default.
• W2085578960 countsByYear W20855789602021 @default.
• W2085578960 crossrefType "journal-article" @default.
• W2085578960 hasAuthorship W2085578960A5022408570 @default.
• W2085578960 hasAuthorship W2085578960A5050907965 @default.
• W2085578960 hasAuthorship W2085578960A5063793551 @default.
• W2085578960 hasAuthorship W2085578960A5064144163 @default.
• W2085578960 hasAuthorship W2085578960A5075048913 @default.
• W2085578960 hasAuthorship W2085578960A5075732221 @default.
• W2085578960 hasAuthorship W2085578960A5090366405 @default.
• W2085578960 hasBestOaLocation W20855789601 @default.
• W2085578960 hasConcept C12519072 @default.
• W2085578960 hasConcept C150903083 @default.
• W2085578960 hasConcept C153911025 @default.
• W2085578960 hasConcept C185592680 @default.
• W2085578960 hasConcept C190283241 @default.
• W2085578960 hasConcept C202751555 @default.
• W2085578960 hasConcept C203014093 @default.
• W2085578960 hasConcept C207001950 @default.
• W2085578960 hasConcept C2779338263 @default.
• W2085578960 hasConcept C2781450507 @default.
• W2085578960 hasConcept C31573885 @default.
• W2085578960 hasConcept C502942594 @default.
• W2085578960 hasConcept C54355233 @default.
• W2085578960 hasConcept C553184892 @default.
• W2085578960 hasConcept C55493867 @default.
• W2085578960 hasConcept C62112901 @default.
• W2085578960 hasConcept C81885089 @default.
• W2085578960 hasConcept C86803240 @default.
• W2085578960 hasConcept C98274493 @default.
• W2085578960 hasConcept C98424977 @default.
• W2085578960 hasConceptScore W2085578960C12519072 @default.
• W2085578960 hasConceptScore W2085578960C150903083 @default.
• W2085578960 hasConceptScore W2085578960C153911025 @default.
• W2085578960 hasConceptScore W2085578960C185592680 @default.
• W2085578960 hasConceptScore W2085578960C190283241 @default.
• W2085578960 hasConceptScore W2085578960C202751555 @default.
• W2085578960 hasConceptScore W2085578960C203014093 @default.
• W2085578960 hasConceptScore W2085578960C207001950 @default.
• W2085578960 hasConceptScore W2085578960C2779338263 @default.
• W2085578960 hasConceptScore W2085578960C2781450507 @default.
• W2085578960 hasConceptScore W2085578960C31573885 @default.
• W2085578960 hasConceptScore W2085578960C502942594 @default.
• W2085578960 hasConceptScore W2085578960C54355233 @default.
• W2085578960 hasConceptScore W2085578960C553184892 @default.
• W2085578960 hasConceptScore W2085578960C55493867 @default.
• W2085578960 hasConceptScore W2085578960C62112901 @default.
• W2085578960 hasConceptScore W2085578960C81885089 @default.
• W2085578960 hasConceptScore W2085578960C86803240 @default.
• W2085578960 hasConceptScore W2085578960C98274493 @default.
• W2085578960 hasConceptScore W2085578960C98424977 @default.
• W2085578960 hasIssue "9" @default.
• W2085578960 hasLocation W20855789601 @default.
• W2085578960 hasLocation W20855789602 @default.
• W2085578960 hasOpenAccess W2085578960 @default.
• W2085578960 hasPrimaryLocation W20855789601 @default.
• W2085578960 hasRelatedWork W1980109110 @default.
• W2085578960 hasRelatedWork W2053279347 @default.
• W2085578960 hasRelatedWork W2328739198 @default.
• W2085578960 hasRelatedWork W2355259601 @default.
• W2085578960 hasRelatedWork W2356566786 @default.
• W2085578960 hasRelatedWork W2375233627 @default.
• W2085578960 hasRelatedWork W2378266499 @default.
• W2085578960 hasRelatedWork W2382426014 @default.

• next