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- W2085581069 abstract "Alpha-mannosidase-II (αM-II) catalyzes the first committed step in the biosynthesis of complex asparagine-linked (N-linked) oligosaccharides (N-glycans). Genetic deficiency of αM-II should abolish complex N-glycan production as reportedly does inhibition of αM-II by swainsonine. We find that mice lacking a functional αM-II gene develop a dyserythropoietic anemia concurrent with loss of erythrocyte complex N-glycans. Unexpectedly, nonerythroid cell types continued to produce complex N-glycans by an alternate pathway comprising a distinct α-mannosidase. These studies reveal cell-type-specific variations in N-linked oligosaccharide biosynthesis and an essential role for αM-II in the formation of erythroid complex N-glycans. αM-II deficiency elicits a phenotype in mice that correlates with human congenital dyserythropoietic anemia type II." @default.
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- W2085581069 date "1997-07-01" @default.
- W2085581069 modified "2023-10-14" @default.
- W2085581069 title "Alpha-Mannosidase-II Deficiency Results in Dyserythropoiesis and Unveils an Alternate Pathway in Oligosaccharide Biosynthesis" @default.
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- W2085581069 doi "https://doi.org/10.1016/s0092-8674(00)80322-0" @default.
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