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- W2085586515 abstract "Spherical microparticles of EGDMA-crosslinked poly(2-hydroxyethyl methacrylate) were prepared by suspension polymerization. Their dynamic and equilibrium swelling were studied in water and ethanol at 25 ° C. The equilibrium swelling behavior was a strong function of the solubility of the incorporated drug. Controlled release studies of phenylephrin-HCl, dimenhydrinate and prednisolone indicated that the drug solubility affects the release behavior. Phenylephrin-HCl from PHEMA microparticles in ethanol showed a true zero-order release kinetic behavior over the first 75% of the release kinetic curve." @default.
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- W2085586515 date "1987-09-01" @default.
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- W2085586515 title "Influence of the drug solubility and dissolution medium on the release from poly(2-hydroxyethylmethacrylate) microspheres" @default.
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- W2085586515 doi "https://doi.org/10.1016/0168-3659(87)90006-x" @default.
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