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• W2085590342 abstract "Background: Neutropenia is one of the most common hematologic manifestations in HIVinfected individuals, present in 5-10% in early stages and more than 50% in advanced stages of the disease. Most of the data reported by SFN emerge from the analysis of cancer patients, did not know of specific data on HIV. Objective: To determine the clinic-epidemiological and etiological SFN episodes in HIV / AIDS. Methods: Prospective analytic study developed from June 2007 until October 2009, at the Hospital Rawson. Inclusion criteria: confirmed HIV infection, more severe neutropenia (500 total neutrophils less), plus fever (T>38 °C). Results: We recruited 18 patients with 22 episodes of SFN, the average age was 38.4%. 36.3% male. A single patient presented other comorbidities associated: chronic HCV infection. Probable causes of SFN (n: 22): Chemotherapy for NHL 5 (22.7%), disseminated mycosis 5 (22.7%). In 54.5% found only associated with drug toxicity as a likely cause, although it was present in all cases. In 59.1% of episodes the SFN was the cause of hospitalization. The 68.2% had pancytopenia. Probable origin of infection: respiratory 45.4%, 36.3% gastrointestinal, skin and soft tissue 27.3%, pharyngeal and odontogenic 18.1%, urinary tract 18.1%, retinitis 9%, and unfocused clinical 9%.The CD4 count was less than 200 in 19 episodes (86.3%). The average duration of neutropenia and fever was 7.6 and 9 days respectively. Of all episodes, 7 (31.8%) had microbiological isolation. Bacterial 5 (71.4%): GNB 4 and Gram-positive cocci 1. Fungi were isolated in 2 episodes (28.5%): 1 Cryptococcus and Histoplasma 1. Microbiological performance of the methods of diagnosis: 17.8% blood cultures, urine cultures 8.7%, bone marrow puncture 22.2%, CSF culture 20% lysis-centrifugation blood cultures by 6.6%. More empirical treatments used: piperacillin / tazobactam 31.8%, piperacillin and amikacin, 27.2%. Mortality was 18.2%. Bacteremia was associated with a 50% mortality. Conclusion: Predominance in young males. High frequency of severe neutropenia related only to drug toxicity. Low yields of blood and urine. GNB were isolated more frequently. Low mortality Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive" @default.
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• W2085590342 date "2010-03-01" @default.
• W2085590342 modified "2023-09-26" @default.
• W2085590342 title "Severe febrile neutropenia (SFN) in HIV / AIDS" @default.
• W2085590342 doi "https://doi.org/10.1016/j.ijid.2010.02.523" @default.
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