FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085594865> ?p ?o ?g. }

• W2085594865 endingPage "1282" @default.
• W2085594865 startingPage "1278" @default.
• W2085594865 abstract "Remifentanil (Ultiva) is a novel, ultra-short-acting opioid which has recently been approved for use as an analgesic during induction and maintenance of general anesthesia. Esmolol is a short-acting beta-blocker used during surgical procedures to reduce heart rate and blood pressure. Both drugs are metabolized by nonspecific esterases in the blood and other tissues and may be administered concomitantly during surgery. The goal of this study was to determine if coadministration of esmolol significantly alters the pharmacokinetics of remifentanil in the rat. Two groups of rats were dosed with remifentanil [25 micrograms/kg/min (n = 8)] and remifentanil plus esmolol [25 and 200 mg/kg/min (n = 7)] for 20 min. Cardiovascular measurements were collected continuously over the course of the study. Serial blood samples (12) were collected over 25 min into test tubes containing 0.5 mL of acetonitrile. Blood samples were extracted (liquid-liquid) with methylene chloride and then analyzed by a validated GC-MS assay. Compartmental data analysis was performed using PCNONLIN. The mean(+/- SD) for Cl and t1/2 observed in treatment I were 390(+/- 98) mL/min/kg and 0.69(+/- 0.27) min and in treatment II were 421(+/- 164) mL/min/kg and 0.56(+/- 0.22) min, respectively. Comparison of clearance, volume of distribution, and terminal half-life between the two groups showed that coadministration of esmolol had no significant (p < 0.05) effect on the pharmacokinetics of remifentanil in the rat." @default.
• W2085594865 created "2016-06-24" @default.
• W2085594865 creator A5010897146 @default.
• W2085594865 creator A5019028585 @default.
• W2085594865 creator A5037359475 @default.
• W2085594865 creator A5066332295 @default.
• W2085594865 creator A5080242181 @default.
• W2085594865 creator A5081353365 @default.
• W2085594865 date "1997-11-01" @default.
• W2085594865 modified "2023-10-07" @default.
• W2085594865 title "Evaluating a Possible Pharmacokinetic Interaction between Remifentanil and Esmolol in the Rat" @default.
• W2085594865 cites W1587634137 @default.
• W2085594865 cites W1964626877 @default.
• W2085594865 cites W1965121445 @default.
• W2085594865 cites W1975477790 @default.
• W2085594865 cites W1977048484 @default.
• W2085594865 cites W1983014932 @default.
• W2085594865 cites W1994678366 @default.
• W2085594865 cites W2007818846 @default.
• W2085594865 cites W2009076067 @default.
• W2085594865 cites W2009439172 @default.
• W2085594865 cites W2023136256 @default.
• W2085594865 cites W2027954442 @default.
• W2085594865 cites W2034656377 @default.
• W2085594865 cites W2035836789 @default.
• W2085594865 cites W2045158569 @default.
• W2085594865 cites W2049622757 @default.
• W2085594865 cites W2056563604 @default.
• W2085594865 cites W2061318391 @default.
• W2085594865 cites W2082275115 @default.
• W2085594865 cites W2082949601 @default.
• W2085594865 cites W2092347493 @default.
• W2085594865 cites W2105061380 @default.
• W2085594865 cites W2114588857 @default.
• W2085594865 cites W2116227776 @default.
• W2085594865 cites W2122833898 @default.
• W2085594865 cites W4247333945 @default.
• W2085594865 cites W4252988395 @default.
• W2085594865 doi "https://doi.org/10.1021/js970079e" @default.
• W2085594865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9383740" @default.
• W2085594865 hasPublicationYear "1997" @default.
• W2085594865 type Work @default.
• W2085594865 sameAs 2085594865 @default.
• W2085594865 citedByCount "35" @default.
• W2085594865 countsByYear W20855948652012 @default.
• W2085594865 countsByYear W20855948652014 @default.
• W2085594865 countsByYear W20855948652016 @default.
• W2085594865 countsByYear W20855948652018 @default.
• W2085594865 countsByYear W20855948652019 @default.
• W2085594865 countsByYear W20855948652020 @default.
• W2085594865 crossrefType "journal-article" @default.
• W2085594865 hasAuthorship W2085594865A5010897146 @default.
• W2085594865 hasAuthorship W2085594865A5019028585 @default.
• W2085594865 hasAuthorship W2085594865A5037359475 @default.
• W2085594865 hasAuthorship W2085594865A5066332295 @default.
• W2085594865 hasAuthorship W2085594865A5080242181 @default.
• W2085594865 hasAuthorship W2085594865A5081353365 @default.
• W2085594865 hasConcept C112705442 @default.
• W2085594865 hasConcept C126322002 @default.
• W2085594865 hasConcept C139254425 @default.
• W2085594865 hasConcept C170493617 @default.
• W2085594865 hasConcept C185592680 @default.
• W2085594865 hasConcept C2776277131 @default.
• W2085594865 hasConcept C2777953023 @default.
• W2085594865 hasConcept C2778891214 @default.
• W2085594865 hasConcept C2780820201 @default.
• W2085594865 hasConcept C2780996683 @default.
• W2085594865 hasConcept C42219234 @default.
• W2085594865 hasConcept C42533223 @default.
• W2085594865 hasConcept C71924100 @default.
• W2085594865 hasConcept C84393581 @default.
• W2085594865 hasConcept C98274493 @default.
• W2085594865 hasConceptScore W2085594865C112705442 @default.
• W2085594865 hasConceptScore W2085594865C126322002 @default.
• W2085594865 hasConceptScore W2085594865C139254425 @default.
• W2085594865 hasConceptScore W2085594865C170493617 @default.
• W2085594865 hasConceptScore W2085594865C185592680 @default.
• W2085594865 hasConceptScore W2085594865C2776277131 @default.
• W2085594865 hasConceptScore W2085594865C2777953023 @default.
• W2085594865 hasConceptScore W2085594865C2778891214 @default.
• W2085594865 hasConceptScore W2085594865C2780820201 @default.
• W2085594865 hasConceptScore W2085594865C2780996683 @default.
• W2085594865 hasConceptScore W2085594865C42219234 @default.
• W2085594865 hasConceptScore W2085594865C42533223 @default.
• W2085594865 hasConceptScore W2085594865C71924100 @default.
• W2085594865 hasConceptScore W2085594865C84393581 @default.
• W2085594865 hasConceptScore W2085594865C98274493 @default.
• W2085594865 hasIssue "11" @default.
• W2085594865 hasLocation W20855948651 @default.
• W2085594865 hasLocation W20855948652 @default.
• W2085594865 hasOpenAccess W2085594865 @default.
• W2085594865 hasPrimaryLocation W20855948651 @default.
• W2085594865 hasRelatedWork W140517024 @default.
• W2085594865 hasRelatedWork W141314330 @default.
• W2085594865 hasRelatedWork W2113582192 @default.
• W2085594865 hasRelatedWork W2277107595 @default.
• W2085594865 hasRelatedWork W2352018793 @default.
• W2085594865 hasRelatedWork W2366589728 @default.

• next