FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085598568> ?p ?o ?g. }

• W2085598568 endingPage "212" @default.
• W2085598568 startingPage "201" @default.
• W2085598568 abstract "1. Small-conductance, sub-picosiemens (sub-pS) Cl- channels in the basolateral membrane of non-stimulated parietal cells in isolated rabbit gastric glands were studied by whole-cell patch-clamp and noise analysis techniques. 2. Voltage-independent whole-cell Cl- currents were recorded from parietal cells equilibrated with Cl(-)-containing solutions. Intracellular application of guanosine-5'-O-(3-thiotriphosphate) (GTP gamma S, 5-200 microM) slowly decreased the whole-cell Cl- current, and its steady-state effect was observed about 6 min after the start of the dialysis. The half-maximal inhibitory concentration of GTP gamma S was about 60 microM. 3. The single Cl- channel conductance was estimated to be 0.37 pS from the variance noise analysis during the GTP gamma S-induced inhibitory process of the whole-cell Cl- current. It is in agreement with the value obtained by a method of power spectrum analysis (0.47 pS). 4. The whole-cell Cl- current was increased by prostaglandin E2 (10 microM). The increased Cl- current was reduced by the subsequent application of GTP gamma S (50 microM), whereas the GTP gamma S (50 microM)-induced inhibition of the Cl- current was not reversed by the subsequent application of prostaglandin E2 (10 microM). 5. The combined intracellular application of GTP gamma S (50 microM) and GDP beta S (500 microM) markedly reduced the inhibitory effect of GTP gamma S, indicating that a GTP-binding protein is involved in the regulation of the Cl- channel. 6. Treatment of parietal cells with pertussis toxin (PTX, 500 ng/ml) for 90-140 min did not affect the GTP gamma S-induced inhibition of the whole-cell Cl- current. 7. Intracellular application of cyclic AMP-dependent protein kinase inhibitor peptide (100 micrograms/ml) or 1,2-bis(O-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) (5 mM, pCa 8) did not affect the GTP gamma S-induced inhibition of the whole-cell Cl- current. 8. The present study has suggested that the opening of the sub-pS Cl- channel is modulated negatively by a PTX-insensitive GTP-binding protein and positively by prostaglandin E2." @default.
• W2085598568 created "2016-06-24" @default.
• W2085598568 creator A5015038980 @default.
• W2085598568 creator A5079627883 @default.
• W2085598568 date "1993-02-01" @default.
• W2085598568 modified "2023-10-18" @default.
• W2085598568 title "Small-conductance Cl- channels in rabbit parietal cells activated by prostaglandin E2 and inhibited by GTP gamma S." @default.
• W2085598568 cites W1548879738 @default.
• W2085598568 cites W1589167027 @default.
• W2085598568 cites W1964143284 @default.
• W2085598568 cites W1982071077 @default.
• W2085598568 cites W1983110944 @default.
• W2085598568 cites W1993763345 @default.
• W2085598568 cites W1997511216 @default.
• W2085598568 cites W2006252556 @default.
• W2085598568 cites W2009667219 @default.
• W2085598568 cites W2014623470 @default.
• W2085598568 cites W2015426350 @default.
• W2085598568 cites W2016608550 @default.
• W2085598568 cites W2025034536 @default.
• W2085598568 cites W2064681367 @default.
• W2085598568 cites W2071728328 @default.
• W2085598568 cites W2076091117 @default.
• W2085598568 cites W2078041571 @default.
• W2085598568 cites W2080210311 @default.
• W2085598568 cites W2100432609 @default.
• W2085598568 cites W2136782902 @default.
• W2085598568 cites W2168735570 @default.
• W2085598568 cites W2399022058 @default.
• W2085598568 cites W2804275696 @default.
• W2085598568 doi "https://doi.org/10.1113/jphysiol.1993.sp019509" @default.
• W2085598568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1175253" @default.
• W2085598568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7688806" @default.
• W2085598568 hasPublicationYear "1993" @default.
• W2085598568 type Work @default.
• W2085598568 sameAs 2085598568 @default.
• W2085598568 citedByCount "15" @default.
• W2085598568 crossrefType "journal-article" @default.
• W2085598568 hasAuthorship W2085598568A5015038980 @default.
• W2085598568 hasAuthorship W2085598568A5079627883 @default.
• W2085598568 hasBestOaLocation W20855985681 @default.
• W2085598568 hasConcept C118716 @default.
• W2085598568 hasConcept C121332964 @default.
• W2085598568 hasConcept C121932024 @default.
• W2085598568 hasConcept C12554922 @default.
• W2085598568 hasConcept C126322002 @default.
• W2085598568 hasConcept C134018914 @default.
• W2085598568 hasConcept C147944092 @default.
• W2085598568 hasConcept C170493617 @default.
• W2085598568 hasConcept C181199279 @default.
• W2085598568 hasConcept C185592680 @default.
• W2085598568 hasConcept C26873012 @default.
• W2085598568 hasConcept C2777995097 @default.
• W2085598568 hasConcept C49773422 @default.
• W2085598568 hasConcept C55493867 @default.
• W2085598568 hasConcept C62478195 @default.
• W2085598568 hasConcept C71924100 @default.
• W2085598568 hasConcept C79879829 @default.
• W2085598568 hasConcept C80631254 @default.
• W2085598568 hasConcept C86803240 @default.
• W2085598568 hasConceptScore W2085598568C118716 @default.
• W2085598568 hasConceptScore W2085598568C121332964 @default.
• W2085598568 hasConceptScore W2085598568C121932024 @default.
• W2085598568 hasConceptScore W2085598568C12554922 @default.
• W2085598568 hasConceptScore W2085598568C126322002 @default.
• W2085598568 hasConceptScore W2085598568C134018914 @default.
• W2085598568 hasConceptScore W2085598568C147944092 @default.
• W2085598568 hasConceptScore W2085598568C170493617 @default.
• W2085598568 hasConceptScore W2085598568C181199279 @default.
• W2085598568 hasConceptScore W2085598568C185592680 @default.
• W2085598568 hasConceptScore W2085598568C26873012 @default.
• W2085598568 hasConceptScore W2085598568C2777995097 @default.
• W2085598568 hasConceptScore W2085598568C49773422 @default.
• W2085598568 hasConceptScore W2085598568C55493867 @default.
• W2085598568 hasConceptScore W2085598568C62478195 @default.
• W2085598568 hasConceptScore W2085598568C71924100 @default.
• W2085598568 hasConceptScore W2085598568C79879829 @default.
• W2085598568 hasConceptScore W2085598568C80631254 @default.
• W2085598568 hasConceptScore W2085598568C86803240 @default.
• W2085598568 hasIssue "1" @default.
• W2085598568 hasLocation W20855985681 @default.
• W2085598568 hasLocation W20855985682 @default.
• W2085598568 hasLocation W20855985683 @default.
• W2085598568 hasOpenAccess W2085598568 @default.
• W2085598568 hasPrimaryLocation W20855985681 @default.
• W2085598568 hasRelatedWork W1516240707 @default.
• W2085598568 hasRelatedWork W2016803641 @default.
• W2085598568 hasRelatedWork W2031151908 @default.
• W2085598568 hasRelatedWork W2035402352 @default.
• W2085598568 hasRelatedWork W2060924285 @default.
• W2085598568 hasRelatedWork W2069167097 @default.
• W2085598568 hasRelatedWork W2088387322 @default.
• W2085598568 hasRelatedWork W2163982123 @default.
• W2085598568 hasRelatedWork W2182658224 @default.
• W2085598568 hasRelatedWork W2230653704 @default.
• W2085598568 hasVolume "461" @default.
• W2085598568 isParatext "false" @default.
• W2085598568 isRetracted "false" @default.

• next