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• W2085598808 abstract "To determine mean arterial pressure (MAP) values during the first 24 hours for stable concordant and discordant extremely low birth weight (ELBW) twins and to ascertain its association with perinatal factors.In ELBW infants, whether singletons or concordant or discordant twins, hypotension is diagnosed by nonspecific clinical signs together with reference arterial pressure values extrapolated from regression models or from scarce actual observations.Retrospective cohort study.We studied 26 sets of concordant and 29 sets of discordant twins, one of whom in each set weighed < or = 800 g at birth. Infants with umbilical cord hemoglobin > or = 14 g/dl and who, although mechanically ventilated, had normal acid-base balance, no patent ductus arteriosus, had not received indomethacin, steroids, muscle relaxants, narcotics, were never treated for hypotension, and survived at least 7 days were considered stable. Arterial pressures were determined by oscillometry (OBP) and direct transducer readings using an umbilical line (MAP). All admission and 10 % of the subsequent readings were measured by OBP; the remaining were measured by MAP.Concordant and discordant twins were similar in demographics, history of chorioamnionitis, preeclampsia, antepartum steroids, cesarean delivery, and neonatal morbidity, but were different in mean birth weight (700 and 789 g), and gestational age (GA) (25 and 27 weeks). Forty-four (82%) of all concordant and 14 (26%) of 58 discordant twins were treated empirically for hypotension. Head ultrasounds were normal or showed Grade I/II in 74% concordant, 81% discordant, and 80% discordant infants with twin-to-twin transfusion syndrome (TTTX). Neonatal mortality was 46%, 45%, and 47%, respectively. There were 14 stable concordant and 22 stable discordant. Their MAPs were different at 1 hour (29 and 34 Torr), 3 hours (29 and 35 Torr), 6 hours (30 and 37 Torr), 12 hours (31 and 36 Torr), 18 hours (33 and 35 Torr), and 24 hours (34 and 36 Torr), respectively. Twenty-six small and 26 large concordant infants had similar MAP from the 1st (27 and 28 Torr) to the 24th hour of life (43 and 43 Torr). Concordant males (often not stable) had lower MAP than concordant females. Seventeen small discordant twins had lower MAP from 1 to 24 hours (28 and 33 Torr) than 17 large discordant twins without TTTX (32 and 38 Torr). Small discordant twins with (donors) and without TTTX had similar trends and MAP values. Large discordant twins with TTTX (recipient) had the highest MAP from birth to 24 hours than any other subgroup of infants and, unlike the others, the MAP trend decreased over time. MAP correlated with GA but not with very low birth weight (< or = 750 g), although with the same GA, those with higher birth weights had higher MAP, and at the same birth weight younger GA twins had lower MAP values.MAP increases from birth to 24 hours in all concordant and discordant twins regardless of condition (stable or unstable), birth weight (large or small) or GA. Recipient TTTX twins had higher MAP throughout but, unlike the other twins, it declined over 24 hours. Small discordant and donor TTTX infants should be considered intrauterine growth restricted and are expected to have MAP commensurable to their GA and not to their birth weight." @default.
• W2085598808 created "2016-06-24" @default.
• W2085598808 creator A5001938292 @default.
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• W2085598808 date "2002-10-01" @default.
• W2085598808 modified "2023-10-15" @default.
• W2085598808 title "Mean Arterial Pressure in Extremely Low Birth Weight Concordant and Discordant Twins During the First Day of Life" @default.
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• W2085598808 doi "https://doi.org/10.1038/sj.jp.7210785" @default.
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