Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085599559> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2085599559 abstract "Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FLIntroduction: Radiation is accepted as an important standard therapy for locally unresectable cancers, and as such is given to approximately 60% of cancer patients. However, radio-resistance and repair of sublethal radiation damage can limit its efficacy. Recent studies have shown that Heat Shock Protein 90 (Hsp90), a molecular chaperone that mediates maturation and activation of client proteins, plays a critical role in establishing resistance to radiation therapy. Inhibiting Hsp90 has been reported to sensitize tumors to radiation, resulting in tumor growth suppression and augmenting therapeutic cell death induction. Unfortunately, many of the Hsp90 inhibitors currently in clinical trials exhibit hepatotoxicity as well as ocular toxicity, hindering their clinical use. Taken together, development of clinically acceptable Hsp90 inhibitors for combination with radiation could serve as an important strategy for improving radiotherapy success.STA-9090 is a second generation Hsp90 inhibitor that has shown potent preclinical activity and is currently in twelve Phase II trials across a broad range of indications. STA-9090 has demonstrated encouraging activity in a Phase II trial in patients with stage IIIB and IV non-small cell lung cancer. Importantly, STA-9090 has displayed a favorable safety profile with substantially lower incidence of hepatic or ocular toxicity than that reported for other Hsp90 inhibitors.Results: We evaluated the radiosensitizing potential of STA-9090 in vivo. Monotherapy treatment with either STA-9090 or 2 Gray (Gy) ionizing irradiation resulted in moderate reductions in human tumor growth rates in a mouse xenograft model. Combination of STA-9090 with 2 Gy irradiation resulted in substantial tumor regression. Increasing the dose of radiation in the combination arm to 4 Gy further enhanced tumor regression, resulting in a 50% reduction in tumor volume. In summary, STA-9090 offers a safe and effective strategy for improving the outcome of radiotherapy in human cancers.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2677. doi:10.1158/1538-7445.AM2011-2677" @default.
- W2085599559 created "2016-06-24" @default.
- W2085599559 creator A5016382860 @default.
- W2085599559 creator A5038282112 @default.
- W2085599559 creator A5057196078 @default.
- W2085599559 creator A5057787401 @default.
- W2085599559 creator A5061021600 @default.
- W2085599559 creator A5079778615 @default.
- W2085599559 date "2011-04-15" @default.
- W2085599559 modified "2023-09-27" @default.
- W2085599559 title "Abstract 2677: Novel Hsp90 inhibitor, STA-9090, for combination with radiotherapy" @default.
- W2085599559 doi "https://doi.org/10.1158/1538-7445.am2011-2677" @default.
- W2085599559 hasPublicationYear "2011" @default.
- W2085599559 type Work @default.
- W2085599559 sameAs 2085599559 @default.
- W2085599559 citedByCount "0" @default.
- W2085599559 crossrefType "proceedings-article" @default.
- W2085599559 hasAuthorship W2085599559A5016382860 @default.
- W2085599559 hasAuthorship W2085599559A5038282112 @default.
- W2085599559 hasAuthorship W2085599559A5057196078 @default.
- W2085599559 hasAuthorship W2085599559A5057787401 @default.
- W2085599559 hasAuthorship W2085599559A5061021600 @default.
- W2085599559 hasAuthorship W2085599559A5079778615 @default.
- W2085599559 hasConcept C104317684 @default.
- W2085599559 hasConcept C121608353 @default.
- W2085599559 hasConcept C126322002 @default.
- W2085599559 hasConcept C150903083 @default.
- W2085599559 hasConcept C185592680 @default.
- W2085599559 hasConcept C197934379 @default.
- W2085599559 hasConcept C205260736 @default.
- W2085599559 hasConcept C207001950 @default.
- W2085599559 hasConcept C2775932338 @default.
- W2085599559 hasConcept C2777560012 @default.
- W2085599559 hasConcept C29730261 @default.
- W2085599559 hasConcept C502942594 @default.
- W2085599559 hasConcept C509974204 @default.
- W2085599559 hasConcept C535046627 @default.
- W2085599559 hasConcept C55493867 @default.
- W2085599559 hasConcept C71924100 @default.
- W2085599559 hasConcept C86803240 @default.
- W2085599559 hasConcept C98274493 @default.
- W2085599559 hasConceptScore W2085599559C104317684 @default.
- W2085599559 hasConceptScore W2085599559C121608353 @default.
- W2085599559 hasConceptScore W2085599559C126322002 @default.
- W2085599559 hasConceptScore W2085599559C150903083 @default.
- W2085599559 hasConceptScore W2085599559C185592680 @default.
- W2085599559 hasConceptScore W2085599559C197934379 @default.
- W2085599559 hasConceptScore W2085599559C205260736 @default.
- W2085599559 hasConceptScore W2085599559C207001950 @default.
- W2085599559 hasConceptScore W2085599559C2775932338 @default.
- W2085599559 hasConceptScore W2085599559C2777560012 @default.
- W2085599559 hasConceptScore W2085599559C29730261 @default.
- W2085599559 hasConceptScore W2085599559C502942594 @default.
- W2085599559 hasConceptScore W2085599559C509974204 @default.
- W2085599559 hasConceptScore W2085599559C535046627 @default.
- W2085599559 hasConceptScore W2085599559C55493867 @default.
- W2085599559 hasConceptScore W2085599559C71924100 @default.
- W2085599559 hasConceptScore W2085599559C86803240 @default.
- W2085599559 hasConceptScore W2085599559C98274493 @default.
- W2085599559 hasLocation W20855995591 @default.
- W2085599559 hasOpenAccess W2085599559 @default.
- W2085599559 hasPrimaryLocation W20855995591 @default.
- W2085599559 hasRelatedWork W1985661574 @default.
- W2085599559 hasRelatedWork W1988533633 @default.
- W2085599559 hasRelatedWork W1997796798 @default.
- W2085599559 hasRelatedWork W2052765156 @default.
- W2085599559 hasRelatedWork W2059229024 @default.
- W2085599559 hasRelatedWork W2078276153 @default.
- W2085599559 hasRelatedWork W2133080613 @default.
- W2085599559 hasRelatedWork W2252683003 @default.
- W2085599559 hasRelatedWork W2332618044 @default.
- W2085599559 hasRelatedWork W2332920119 @default.
- W2085599559 hasRelatedWork W2413186675 @default.
- W2085599559 hasRelatedWork W2563102725 @default.
- W2085599559 hasRelatedWork W287605918 @default.
- W2085599559 hasRelatedWork W2885851430 @default.
- W2085599559 hasRelatedWork W2907113073 @default.
- W2085599559 hasRelatedWork W2954054212 @default.
- W2085599559 hasRelatedWork W3013055025 @default.
- W2085599559 hasRelatedWork W3019859972 @default.
- W2085599559 hasRelatedWork W3077207536 @default.
- W2085599559 hasRelatedWork W3081797545 @default.
- W2085599559 isParatext "false" @default.
- W2085599559 isRetracted "false" @default.
- W2085599559 magId "2085599559" @default.
- W2085599559 workType "article" @default.