FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085607872> ?p ?o ?g. }

• W2085607872 endingPage "2835" @default.
• W2085607872 startingPage "2822" @default.
• W2085607872 abstract "The metabolism of cholesterol and its 5-dihydro derivative, cholestanol, was investigated by means of sterol balance and isotope kinetic techniques in 3 subjects with cerebrotendinous xanthomatosis (CTX) and 11 other individuals. All subjects were hospitalized on a metabolic ward and were fed diets practically free of cholesterol and cholestanol. After the intravenous administration of [1,2-(3)H]cholestanol, the radioactive sterol was transported and esterified in plasma lipoproteins in an identical manner to cholesterol. In these short-term experiments, the specific activity-time curves of plasma cholestanol conformed to two-pool models in both the CTX and control groups. However, cholestanol plasma concentrations, total body miscible pools, and daily synthesis rates were two to five times greater in the CTX than control individuals. The short-term specific activity decay curves of plasma [4-(14)C]cholesterol also conformed to two-pool models in both groups. However, in the CTX subjects the decay was more rapid, and daily cholesterol synthesis was nearly double that of the control subjects. Plasma concentrations and the sizes of the rapidly turning over pool of exchangeable cholesterol were apparently small in the CTX subjects, and these measurements did not correlate with the large cholesterol deposits found in tendon and tuberous xanthomas. Despite active cholesterol synthesis, bile acid formation was subnormal in the CTX subjects. However, bile acid sequestration was accompanied by a rise in plasma cholestanol levels and greatly augmented fecal cholestanol outputs. In contrast, the administration of clofibrate lowered plasma cholesterol levels 50% and presumably reduced synthesis in the CTX subjects. Plasma cholesterol concentrations and fecal steroid excretion did not change significantly during this therapy. These findings indicate that the excessive tissue deposits of cholesterol and cholestanol that characterize CTX were associated with hyperactive neutral sterol synthesis. The demonstration of subnormal bile acid formation suggests that defective bile acid synthesis may predispose to the neutral sterol abnormalities." @default.
• W2085607872 created "2016-06-24" @default.
• W2085607872 creator A5056794714 @default.
• W2085607872 creator A5085224100 @default.
• W2085607872 date "1973-11-01" @default.
• W2085607872 modified "2023-09-25" @default.
• W2085607872 title "The Metabolism of Cholestanol, Cholesterol, and Bile Acids in Cerebrotendinous Xanthomatosis" @default.
• W2085607872 cites W177273302 @default.
• W2085607872 cites W1879297302 @default.
• W2085607872 cites W1969832325 @default.
• W2085607872 cites W1989703035 @default.
• W2085607872 cites W1990873832 @default.
• W2085607872 cites W1995239175 @default.
• W2085607872 cites W2002044281 @default.
• W2085607872 cites W2009641604 @default.
• W2085607872 cites W2015223452 @default.
• W2085607872 cites W2017248949 @default.
• W2085607872 cites W2036295891 @default.
• W2085607872 cites W2054328698 @default.
• W2085607872 cites W2063885280 @default.
• W2085607872 cites W2070830731 @default.
• W2085607872 cites W2079151187 @default.
• W2085607872 cites W2080427118 @default.
• W2085607872 cites W2099958885 @default.
• W2085607872 cites W2105394775 @default.
• W2085607872 cites W2128798036 @default.
• W2085607872 cites W2135503869 @default.
• W2085607872 cites W2162719733 @default.
• W2085607872 cites W2182413963 @default.
• W2085607872 cites W2188473606 @default.
• W2085607872 cites W2207355009 @default.
• W2085607872 cites W2257107238 @default.
• W2085607872 cites W2314766391 @default.
• W2085607872 cites W2402466980 @default.
• W2085607872 cites W2414121512 @default.
• W2085607872 doi "https://doi.org/10.1172/jci107478" @default.
• W2085607872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/302550" @default.
• W2085607872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4355999" @default.
• W2085607872 hasPublicationYear "1973" @default.
• W2085607872 type Work @default.
• W2085607872 sameAs 2085607872 @default.
• W2085607872 citedByCount "159" @default.
• W2085607872 countsByYear W20856078722012 @default.
• W2085607872 countsByYear W20856078722015 @default.
• W2085607872 countsByYear W20856078722016 @default.
• W2085607872 countsByYear W20856078722017 @default.
• W2085607872 countsByYear W20856078722018 @default.
• W2085607872 countsByYear W20856078722019 @default.
• W2085607872 countsByYear W20856078722020 @default.
• W2085607872 countsByYear W20856078722021 @default.
• W2085607872 countsByYear W20856078722023 @default.
• W2085607872 crossrefType "journal-article" @default.
• W2085607872 hasAuthorship W2085607872A5056794714 @default.
• W2085607872 hasAuthorship W2085607872A5085224100 @default.
• W2085607872 hasBestOaLocation W20856078721 @default.
• W2085607872 hasConcept C126322002 @default.
• W2085607872 hasConcept C134018914 @default.
• W2085607872 hasConcept C185592680 @default.
• W2085607872 hasConcept C2778163477 @default.
• W2085607872 hasConcept C2778718757 @default.
• W2085607872 hasConcept C2779399885 @default.
• W2085607872 hasConcept C2779496979 @default.
• W2085607872 hasConcept C2909350188 @default.
• W2085607872 hasConcept C2910061293 @default.
• W2085607872 hasConcept C62231903 @default.
• W2085607872 hasConcept C71924100 @default.
• W2085607872 hasConcept C86803240 @default.
• W2085607872 hasConceptScore W2085607872C126322002 @default.
• W2085607872 hasConceptScore W2085607872C134018914 @default.
• W2085607872 hasConceptScore W2085607872C185592680 @default.
• W2085607872 hasConceptScore W2085607872C2778163477 @default.
• W2085607872 hasConceptScore W2085607872C2778718757 @default.
• W2085607872 hasConceptScore W2085607872C2779399885 @default.
• W2085607872 hasConceptScore W2085607872C2779496979 @default.
• W2085607872 hasConceptScore W2085607872C2909350188 @default.
• W2085607872 hasConceptScore W2085607872C2910061293 @default.
• W2085607872 hasConceptScore W2085607872C62231903 @default.
• W2085607872 hasConceptScore W2085607872C71924100 @default.
• W2085607872 hasConceptScore W2085607872C86803240 @default.
• W2085607872 hasIssue "11" @default.
• W2085607872 hasLocation W20856078721 @default.
• W2085607872 hasLocation W20856078722 @default.
• W2085607872 hasLocation W20856078723 @default.
• W2085607872 hasLocation W20856078724 @default.
• W2085607872 hasOpenAccess W2085607872 @default.
• W2085607872 hasPrimaryLocation W20856078721 @default.
• W2085607872 hasRelatedWork W1486286511 @default.
• W2085607872 hasRelatedWork W1494163573 @default.
• W2085607872 hasRelatedWork W1719777700 @default.
• W2085607872 hasRelatedWork W1966824384 @default.
• W2085607872 hasRelatedWork W2018315032 @default.
• W2085607872 hasRelatedWork W2065182122 @default.
• W2085607872 hasRelatedWork W2078657586 @default.
• W2085607872 hasRelatedWork W2080427118 @default.
• W2085607872 hasRelatedWork W2085607872 @default.
• W2085607872 hasRelatedWork W2103961046 @default.
• W2085607872 hasVolume "52" @default.
• W2085607872 isParatext "false" @default.

• next