Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085609996> ?p ?o ?g. }
- W2085609996 endingPage "2168" @default.
- W2085609996 startingPage "2164" @default.
- W2085609996 abstract "High-grade non-Hodgkin's lymphomas (NHL) can potentially be cured with combination chemotherapy, although the optimum schedules still have to be defined. Clinical trials with intensive chemotherapy are predominantly limited by myelosuppression. Here, haematopoetic growth factors open up the possibility of reducing chemotherapy-associated toxicities. In this randomised pilot study, we investigated the effects of a recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) following combined chemotherapy with vincristine, doxorubicin, cyclophosphamide, prednisone and etoposide (VACPE). A total of 35 patients with high-grade NHLs were randomised to receive either rhGM-CSF or placebo during the first two chemotherapy cycles and rhGM-CSF for all following cycles. rhGM-CSF was administered at a dosage of 5 μg/kg for 10 days or until neutrophils were > 1/nl following chemotherapy. The analyses revealed a significant reduction of neutropenia and duration of neutropenia in the rhGM-CSF group. Adverse events were rare and generally mild apart from one anaphylactoid reaction. No effects of rhGM-CSF were observed concerning the platelet nadir or duration of thrombocytopenia. The benefit of rhGM-CSF for response induction and survival via rhGM-CSF-supported dose intensification remains to be determined." @default.
- W2085609996 created "2016-06-24" @default.
- W2085609996 creator A5001834448 @default.
- W2085609996 creator A5013658911 @default.
- W2085609996 creator A5038062532 @default.
- W2085609996 creator A5048052916 @default.
- W2085609996 creator A5066213019 @default.
- W2085609996 creator A5068927061 @default.
- W2085609996 date "1995-12-01" @default.
- W2085609996 modified "2023-09-26" @default.
- W2085609996 title "Recombinant human granulocyte-macrophage colony-stimulating factor after combined chemotherapy in high-grade non-Hodgkin's lymphoma—a randomised pilot study" @default.
- W2085609996 cites W122133057 @default.
- W2085609996 cites W1529388857 @default.
- W2085609996 cites W1896652710 @default.
- W2085609996 cites W1911120442 @default.
- W2085609996 cites W1969194020 @default.
- W2085609996 cites W1977157092 @default.
- W2085609996 cites W2032431943 @default.
- W2085609996 cites W2036109661 @default.
- W2085609996 cites W2036631709 @default.
- W2085609996 cites W2071813692 @default.
- W2085609996 cites W2077567025 @default.
- W2085609996 cites W2103937418 @default.
- W2085609996 cites W2104579333 @default.
- W2085609996 cites W2118347775 @default.
- W2085609996 cites W2129319674 @default.
- W2085609996 cites W2135729119 @default.
- W2085609996 cites W2143855542 @default.
- W2085609996 cites W2144843163 @default.
- W2085609996 cites W2152474929 @default.
- W2085609996 cites W2247456506 @default.
- W2085609996 cites W2249202800 @default.
- W2085609996 cites W2300550500 @default.
- W2085609996 cites W2313477330 @default.
- W2085609996 cites W2318548335 @default.
- W2085609996 cites W2318772898 @default.
- W2085609996 cites W2341557816 @default.
- W2085609996 cites W2399636127 @default.
- W2085609996 cites W2408564785 @default.
- W2085609996 cites W2411085218 @default.
- W2085609996 cites W2413877714 @default.
- W2085609996 cites W2413900776 @default.
- W2085609996 cites W2413981611 @default.
- W2085609996 cites W2417558554 @default.
- W2085609996 cites W2418061882 @default.
- W2085609996 cites W2503620172 @default.
- W2085609996 cites W2588480825 @default.
- W2085609996 cites W3024436806 @default.
- W2085609996 cites W8064160 @default.
- W2085609996 cites W2001918786 @default.
- W2085609996 doi "https://doi.org/10.1016/0959-8049(95)00195-6" @default.
- W2085609996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8652236" @default.
- W2085609996 hasPublicationYear "1995" @default.
- W2085609996 type Work @default.
- W2085609996 sameAs 2085609996 @default.
- W2085609996 citedByCount "7" @default.
- W2085609996 crossrefType "journal-article" @default.
- W2085609996 hasAuthorship W2085609996A5001834448 @default.
- W2085609996 hasAuthorship W2085609996A5013658911 @default.
- W2085609996 hasAuthorship W2085609996A5038062532 @default.
- W2085609996 hasAuthorship W2085609996A5048052916 @default.
- W2085609996 hasAuthorship W2085609996A5066213019 @default.
- W2085609996 hasAuthorship W2085609996A5068927061 @default.
- W2085609996 hasConcept C126322002 @default.
- W2085609996 hasConcept C143998085 @default.
- W2085609996 hasConcept C2776694085 @default.
- W2085609996 hasConcept C2776755627 @default.
- W2085609996 hasConcept C2777063308 @default.
- W2085609996 hasConcept C2777478134 @default.
- W2085609996 hasConcept C2778119113 @default.
- W2085609996 hasConcept C2778690821 @default.
- W2085609996 hasConcept C2778720950 @default.
- W2085609996 hasConcept C2779338263 @default.
- W2085609996 hasConcept C2779429289 @default.
- W2085609996 hasConcept C2781303535 @default.
- W2085609996 hasConcept C71924100 @default.
- W2085609996 hasConcept C90924648 @default.
- W2085609996 hasConceptScore W2085609996C126322002 @default.
- W2085609996 hasConceptScore W2085609996C143998085 @default.
- W2085609996 hasConceptScore W2085609996C2776694085 @default.
- W2085609996 hasConceptScore W2085609996C2776755627 @default.
- W2085609996 hasConceptScore W2085609996C2777063308 @default.
- W2085609996 hasConceptScore W2085609996C2777478134 @default.
- W2085609996 hasConceptScore W2085609996C2778119113 @default.
- W2085609996 hasConceptScore W2085609996C2778690821 @default.
- W2085609996 hasConceptScore W2085609996C2778720950 @default.
- W2085609996 hasConceptScore W2085609996C2779338263 @default.
- W2085609996 hasConceptScore W2085609996C2779429289 @default.
- W2085609996 hasConceptScore W2085609996C2781303535 @default.
- W2085609996 hasConceptScore W2085609996C71924100 @default.
- W2085609996 hasConceptScore W2085609996C90924648 @default.
- W2085609996 hasIssue "13-14" @default.
- W2085609996 hasLocation W20856099961 @default.
- W2085609996 hasLocation W20856099962 @default.
- W2085609996 hasOpenAccess W2085609996 @default.
- W2085609996 hasPrimaryLocation W20856099961 @default.
- W2085609996 hasRelatedWork W160156331 @default.
- W2085609996 hasRelatedWork W1942971125 @default.