FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085630595> ?p ?o ?g. }

• W2085630595 endingPage "4893" @default.
• W2085630595 startingPage "4885" @default.
• W2085630595 abstract "The in vitro growth inhibition activity of new thiosemicarbazone derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, are described. The designed compounds combine in the same molecule the thiosemicarbazone function, recently described as a potent cruzain-inhibitor moiety, and the recognised 5-nitrofuryl group, an oxidative stress promoter. Some of the derivatives were found to be very active against the cultured (epimastigote) form of the parasite, being 1.5–1.7-fold more active than the reference compound, Nifurtimox. Free radicals production was detected when the compounds were incubated in presence of mammalian-liver microsomes. The thiosemicarbazones’ capacity to act as pharmacophore in the cruzain inhibition process was theoretically analysed. Frontier molecular orbital HOMO was found as an adequate descriptor in this process. Acute in vivo toxicity of two of the more active derivatives was evaluated. The results showed that these compounds are among the most potent 5-nitrofuryl derivatives tested against this parasite thus support further in vivo studies of some of these thiosemicarbazones." @default.
• W2085630595 created "2016-06-24" @default.
• W2085630595 creator A5000535824 @default.
• W2085630595 creator A5002231168 @default.
• W2085630595 creator A5009185272 @default.
• W2085630595 creator A5032771544 @default.
• W2085630595 creator A5038220750 @default.
• W2085630595 creator A5049255660 @default.
• W2085630595 creator A5073663213 @default.
• W2085630595 creator A5080927889 @default.
• W2085630595 creator A5081586056 @default.
• W2085630595 creator A5081967876 @default.
• W2085630595 creator A5084310464 @default.
• W2085630595 date "2004-09-01" @default.
• W2085630595 modified "2023-09-29" @default.
• W2085630595 title "In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones" @default.
• W2085630595 cites W1967920937 @default.
• W2085630595 cites W1971502035 @default.
• W2085630595 cites W1973258909 @default.
• W2085630595 cites W1984506240 @default.
• W2085630595 cites W1986371873 @default.
• W2085630595 cites W1987383722 @default.
• W2085630595 cites W1991043874 @default.
• W2085630595 cites W1992349155 @default.
• W2085630595 cites W2003748541 @default.
• W2085630595 cites W2008429541 @default.
• W2085630595 cites W2012636842 @default.
• W2085630595 cites W2017661606 @default.
• W2085630595 cites W2018444894 @default.
• W2085630595 cites W2022335567 @default.
• W2085630595 cites W2025753673 @default.
• W2085630595 cites W2039602651 @default.
• W2085630595 cites W2043355666 @default.
• W2085630595 cites W2045594331 @default.
• W2085630595 cites W2059333315 @default.
• W2085630595 cites W2078046457 @default.
• W2085630595 cites W2086324268 @default.
• W2085630595 cites W2086737863 @default.
• W2085630595 cites W2095443401 @default.
• W2085630595 cites W2130023734 @default.
• W2085630595 cites W2135747071 @default.
• W2085630595 cites W2144377225 @default.
• W2085630595 cites W2148182271 @default.
• W2085630595 cites W2149024161 @default.
• W2085630595 cites W4246123945 @default.
• W2085630595 cites W4248107770 @default.
• W2085630595 doi "https://doi.org/10.1016/j.bmc.2004.07.003" @default.
• W2085630595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15336268" @default.
• W2085630595 hasPublicationYear "2004" @default.
• W2085630595 type Work @default.
• W2085630595 sameAs 2085630595 @default.
• W2085630595 citedByCount "117" @default.
• W2085630595 countsByYear W20856305952012 @default.
• W2085630595 countsByYear W20856305952013 @default.
• W2085630595 countsByYear W20856305952014 @default.
• W2085630595 countsByYear W20856305952015 @default.
• W2085630595 countsByYear W20856305952016 @default.
• W2085630595 countsByYear W20856305952017 @default.
• W2085630595 countsByYear W20856305952018 @default.
• W2085630595 countsByYear W20856305952019 @default.
• W2085630595 countsByYear W20856305952020 @default.
• W2085630595 countsByYear W20856305952022 @default.
• W2085630595 countsByYear W20856305952023 @default.
• W2085630595 crossrefType "journal-article" @default.
• W2085630595 hasAuthorship W2085630595A5000535824 @default.
• W2085630595 hasAuthorship W2085630595A5002231168 @default.
• W2085630595 hasAuthorship W2085630595A5009185272 @default.
• W2085630595 hasAuthorship W2085630595A5032771544 @default.
• W2085630595 hasAuthorship W2085630595A5038220750 @default.
• W2085630595 hasAuthorship W2085630595A5049255660 @default.
• W2085630595 hasAuthorship W2085630595A5073663213 @default.
• W2085630595 hasAuthorship W2085630595A5080927889 @default.
• W2085630595 hasAuthorship W2085630595A5081586056 @default.
• W2085630595 hasAuthorship W2085630595A5081967876 @default.
• W2085630595 hasAuthorship W2085630595A5084310464 @default.
• W2085630595 hasConcept C112418997 @default.
• W2085630595 hasConcept C136764020 @default.
• W2085630595 hasConcept C150903083 @default.
• W2085630595 hasConcept C159047783 @default.
• W2085630595 hasConcept C185592680 @default.
• W2085630595 hasConcept C202751555 @default.
• W2085630595 hasConcept C207001950 @default.
• W2085630595 hasConcept C2776120743 @default.
• W2085630595 hasConcept C2776171842 @default.
• W2085630595 hasConcept C2776568683 @default.
• W2085630595 hasConcept C2777625466 @default.
• W2085630595 hasConcept C2781049234 @default.
• W2085630595 hasConcept C41008148 @default.
• W2085630595 hasConcept C55493867 @default.
• W2085630595 hasConcept C71240020 @default.
• W2085630595 hasConcept C71928629 @default.
• W2085630595 hasConcept C86803240 @default.
• W2085630595 hasConceptScore W2085630595C112418997 @default.
• W2085630595 hasConceptScore W2085630595C136764020 @default.
• W2085630595 hasConceptScore W2085630595C150903083 @default.
• W2085630595 hasConceptScore W2085630595C159047783 @default.
• W2085630595 hasConceptScore W2085630595C185592680 @default.
• W2085630595 hasConceptScore W2085630595C202751555 @default.

• next