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• W2085634797 abstract "We have isolated a mouse cDNA of 5.7 kb, encoding a new member of the family of receptor‐like protein tyrosine phosphatases, termed mRPTPμ. The cDNA predicts a protein of 1432 amino acids (not including signal peptide) with a calculated M r of 161 636. In addition, we have cloned the human homologue, hRPTPμ, which shows 98.7% amino acid identity to mRPTPμ. The predicted mRPTPμ protein consists of a 722 amino acid extracellular region, containing 13 potential N ‐glycosylation sites, a single transmembrane domain and a 688 amino acid intracellular part containing 2 tandem repeats homologous to the catalytic domains of other tyrosine phosphatases. The N‐terminal extracellular part contains a region of about 170 amino acids with no sequence similarities to known proteins, followed by one Ig‐like domain and 4 fibronectin type III‐like domains. The intracellular part is unique in that the region between the transmembrane domain and the first catalytic domain is about twice as large as in other receptor‐like protein tyrosine phosphatases. RNA blot analysis reveals a single transcript, that is most abundant in lung and present in much lower amounts in brain and heart. Transfection of the mRPTPμ cDNA into COS cells results in the synthesis of a protein with an apparent M r of 195 000, as detected in immunoblots using an antipeptide antibody. The human RPTPμ gene is localized on chromosome 18pter‐q11, a region with frequent abnormalities implicated in human cancer." @default.
• W2085634797 created "2016-06-24" @default.
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• W2085634797 date "1991-09-23" @default.
• W2085634797 modified "2023-10-17" @default.
• W2085634797 title "Cloning, expression and chromosomal localization of a new putative receptor‐like protein tyrosine phosphatase" @default.
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• W2085634797 doi "https://doi.org/10.1016/0014-5793(91)81241-y" @default.
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• W2085634797 hasPublicationYear "1991" @default.
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