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• W2085643090 abstract "During oogenesis, mammalian eggs accumulate proteins required for early embryogenesis. Although limited data suggest a vital role of these maternal factors in chromatin reprogramming and embryonic genome activation, the full range of their functions in preimplantation development remains largely unknown. Here we report a role for maternal proteins in maintaining chromosome stability and euploidy in early-cleavage mouse embryogenesis. Filia , expressed in growing oocytes, encodes a protein that binds to MATER and participates in a subcortical maternal complex essential for cleavage-stage embryogenesis. The depletion of maternal stores of Filia impairs preimplantation embryo development with a high incidence of aneuploidy that results from abnormal spindle assembly, chromosome misalignment, and spindle assembly checkpoint (SAC) inactivation. In helping to ensure normal spindle morphogenesis, Filia regulates the proper allocation of the key spindle assembly regulators (i.e., AURKA, PLK1, and γ-tubulin) to the microtubule-organizing center via the RhoA signaling pathway. Concurrently, Filia is required for the placement of MAD2, an essential component of the SAC, to kinetochores to enable SAC function. Thus, Filia is central to integrating the spatiotemporal localization of regulators that helps ensure euploidy and high-quality cell cycle progression in preimplantation mouse development. Defects in the well-conserved human homologue could play a similar role and account for recurrent human fetal wastage." @default.
• W2085643090 created "2016-06-24" @default.
• W2085643090 creator A5000326765 @default.
• W2085643090 creator A5038255472 @default.
• W2085643090 date "2009-05-05" @default.
• W2085643090 modified "2023-10-16" @default.
• W2085643090 title "Role of <i>Filia</i> , a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis" @default.
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• W2085643090 doi "https://doi.org/10.1073/pnas.0900519106" @default.
• W2085643090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2678599" @default.
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• W2085643090 hasPublicationYear "2009" @default.
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